Moxibustion for diarrhea-predominant irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Dai, Yan-Qi; Weng, Heng; Wang, Qing; X, Guo; Wu, Qiong; Zhou, Lin; Huang, Li

doi:10.1016/j.ctcp.2021.101532

Cited by 6 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although several systematic review and meta-analysis on acupuncture and moxibustion has been conducted (11,(44)(45)(46)(47), primary outcome assessment of these studies has been limited to effectiveness rate. The continuous outcome from one of these reviews used Chinese Medicine symptoms integral with weighted mean difference (WMD) to estimate the efficacy (45).…”

Section: Principal Findings and Comparison With Other Studiesmentioning

confidence: 99%

Clinical evidence of acupuncture and moxibustion for irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Yang

Rao

Zhan

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

BackgroundAcupuncture and moxibustion have been widely used in the treatment of Irritable Bowel Syndrome (IBS). But the evidence that acupuncture and moxibustion for IBS reduction of symptom severity and abdominal pain, and improvement of quality of life is scarce.MethodsPubMed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), Wanfang Database, China Biomedical Literature Service System (SinoMed), and unpublished sources were searched from inception until June 30, 2022. The quality of RCTs was assessed with the Cochrane Collaboration risk of bias tool. The strength of the evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation system (GRADE). Trial sequential analysis (TSA) was conducted to determine whether the participants in the included trials had reached optimal information size and whether the cumulative data was adequately powered to evaluate outcomes.ResultsA total of 31 RCTs were included. Acupuncture helped reduce the severity of symptoms more than pharmaceutical drugs (MD, −35.45; 95% CI, −48.21 to −22.68; I2 = 71%). TSA showed the cumulative Z score crossed O'Brien-Fleming alpha-spending significance boundaries. Acupuncture wasn't associated with symptom severity reduction (SMD, 0.03, 95% CI, −0.25 to 0.31, I2 = 46%), but exhibited therapeutic benefits on abdominal pain (SMD, −0.24; 95% CI, −0.48 to −0.01; I2 = 8%) compared to sham acupuncture. Moxibustion show therapeutic benefits compared to sham moxibustion on symptom severity (SMD, −3.46, 95% CI, −5.66 to −1.27, I2 = 95%) and abdominal pain (SMD, −2.74, 95% CI, −4.81 to −0.67, I2 = 96%). Acupuncture (SMD, −0.46; 95% CI, −0.68 to −0.24; I2 = 47%) and the combination of acupuncture and moxibustion (SMD, −2.00; 95% CI, −3.04 to −0.96; I2 = 90%) showed more benefit for abdominal pain compared to pharmacological medications as well as shams. Acupuncture (MD, 4.56; 95% CI, 1.46–7.67; I2 = 79%) and moxibustion (MD, 6.97; 95% CI, 5.78–8.16; I2 = 21%) were more likely to improve quality of life than pharmaceutical drugs.ConclusionAcupuncture and/or moxibustion are beneficial for symptom severity, abdominal pain and quality of life in IBS. However, in sham control trials, acupuncture hasn't exhibited robust and stable evidence, and moxibustion's results show great heterogeneity. Hence, more rigorous sham control trials of acupuncture or moxibustion are necessary.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=262118, identifier CRD42021262118.

show abstract

Section: Principal Findings and Comparison With Other Studiesmentioning

confidence: 99%

Clinical evidence of acupuncture and moxibustion for irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Yang

Rao

Zhan

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…Auch andere pathologische Befunde (Blutbild, Nieren-und Leberwerte, Schilddrüsenfunktion, Entzündungsmarker) konnten nicht erhoben werden. Nach den Kriterien der TCM kann es sich beim RDS um verschiedene Störungen handeln, die sowohl durch innere als auch äußere pathogene Faktoren ausgelöst werden können [6]. Lebensstil, Ernährungsweise aber auch seelische und psychische Belastungen spielen eine maßgebliche Rolle bei der Entstehung des Krankheitsbilds.…”

Section: Anamnese Und Diagnostikunclassified

Behandlung funktioneller Bauchschmerzen im Kindes- und Jugendalter mit TCM

Schmid¹,

Agarwal²

2022

AkupunkturPraxis

View full text Add to dashboard Cite

Die nachstehende Fallvorstellung zeigt die Interventionsmöglichkeit mittels TCM bei funktionellen Bauchschmerzen einer Jugendlichen auf. Abdominale Schmerzen zählen zu den am häufigsten beklagten Beschwerden im Kindes- und Jugendalter. Oft lässt sich kein morphologisches Korrelat finden, was zu großen Sorgen und Nöten sowohl bei den Patienten als auch den Eltern führt. Zudem ist die Lebensqualität von Kindern mit funktionellen Abdominalbeschwerden (functional gastrointestinal diseases [FGID]) deutlich reduziert. Nach Ausschluss möglicher organischer Ursachen wird anhand der nachfolgenden Fallbeschreibung dargestellt, welche Therapieoptionen die TCM beim Reizdarmsyndrom bietet.

show abstract

“…For example, a meta-analysis indicated that acupuncture had a beneficial effect on knee osteoarthritis in reducing pain and improved patient function activities ( Tian et al, 2022 ). In the treatment of diarrhea-predominant irritable bowel syndrome, moxibustion had a more positive influence on the symptoms as compared to western medicines, TCM prescription, or acupuncture ( Dai et al, 2022 ). In terms of improving immune function, studies have found that acupuncture significantly increased the numbers of white blood cells in patients with breast cancer who were undergoing ameliorating leukopenia during chemotherapy ( Shih et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Acupoints such as ST36 (Zusanli) and EX-LE5 (Xiyan) were usually used in the treatments of knee osteoarthritis ( Ma et al, 2018 ; Tong et al, 2021 ; Tian et al, 2022 ; Wei et al, 2022 ). To relieve diarrhea-predominant irritable bowel syndrome, ST36 and ST37 (Shangjuxu) were chosen with the highest frequency during the moxibustion treatments ( Wang et al, 2018 ; Bao et al, 2019 ; Dai et al, 2022 ). Acupoints like ST36, SP6 (Sanyinjiao), BL23 (Shenyu), etc.…”

Section: Introductionmentioning

confidence: 99%

Shared nociceptive dorsal root ganglion neurons participating in acupoint sensitization

Liu²,

Chen³

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

When the body is under pathological stress (injury or disease), the status of associated acupoints changes, including decreased pain threshold. Such changes in acupoint from a “silent” to an “active” state are considered “acupoint sensitization,” which has become an important indicator of acupoint selection. However, the mechanism of acupoint sensitization remains unclear. In this study, by retrograde tracing, morphological, chemogenetic, and behavioral methods, we found there are some dorsal root ganglion (DRG) neurons innervating the ST36 acupoint and ipsilateral hind paw (IHP) plantar simultaneously. Inhibition of these shared neurons induced analgesia in the complete Freund’s adjuvant (CFA) pain model and obstruction of nociceptive sensation in normal mice, and elevated the mechanical pain threshold (MPT) of ST36 acupoint in the CFA model. Excitation of shared neurons induced pain and declined the MPT of ST36 acupoint. Furthermore, most of the shared DRG neurons express TRPV1, a marker of nociceptive neurons. These results indicate that the shared nociceptive DRG neurons participate in ST36 acupoint sensitization in CFA-induced chronic pain. This raised a neural mechanism of acupoint sensitization at the level of primary sensory transmission.

show abstract

Moxibustion for diarrhea-predominant irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Cited by 6 publications

References 21 publications

Clinical evidence of acupuncture and moxibustion for irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Clinical evidence of acupuncture and moxibustion for irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

Behandlung funktioneller Bauchschmerzen im Kindes- und Jugendalter mit TCM

Shared nociceptive dorsal root ganglion neurons participating in acupoint sensitization

Contact Info

Product

Resources

About