Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial

Han, Kyungsun; Kim, Mi-Kyung; Kim, Eun Jung; Park, Yeon Cheol; Kwon, Ojin; Kim, Ae Ran; Park, Hyo Ju; Park, Yang-Chun; Cho, Jung Hyo; Kim, Joo Hee; Lee, Jun-Hwan

doi:10.1002/cam4.4020

Cited by 25 publications

(22 citation statements)

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“…These results align well with a growing body of literature demonstrating the ability of acupuncture and moxibustion to help alleviate the fatigue [ 26 , 27 ] and insomnia [ 28 , 29 ] experienced by patients diagnosed with or recovering from cancer. Strikingly, ILM failed to significantly improve fatigue as compared to sham treatment at the end of the treatment interval despite exhibiting significant benefits at later follow-up time points, consistent with the results of another recent moxibustion trial [ 27 ]. This suggests that ILM can exhibit prolonged benefits as a treatment for CRF, although the underlying mechanisms remain to be fully clarified.…”

Section: Discussionsupporting

confidence: 86%

Infrared laser moxibustion for cancer-related fatigue in breast cancer survivors: a randomized controlled trial

Mao,

Jin,

Xie

et al. 2024

Breast Cancer Res

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Background Cancer-related fatigue (CRF) is a pervasive, persistent, and distressing symptom experienced by cancer patients, for which few treatments are available. We investigated the efficacy and safety of infrared laser moxibustion (ILM) for improving fatigue in breast cancer survivors. Methods A three-arm, randomized, sham-controlled clinical trial (6-week intervention plus 12-week observational follow-up) was conducted at a tertiary hospital in Shanghai, China. The female breast cancer survivors with moderate to severe fatigue were randomized 2:2:1 to ILM (n = 56) sham ILM (n = 56), and Waitlist control (WLC)(n = 28) groups. Patients in the ILM and sham ILM (SILM) groups received real or sham ILM treatment, 2 sessions per week for 6 weeks, for a total of 12 sessions. The primary outcome was change in the Brief Fatigue Inventory (BFI) score from baseline to week 6 with follow-up until week 18 assessed in the intention-to-treat population. Results Between June 2018 and July 2021, 273 patients were assessed for eligibility, and 140 patients were finally enrolled and included in the intention-to-treat analysis. Compared with WLC, ILM reduced the average BFI score by 0.9 points (95% CI, 0.3 to 1.6, P = .007) from baseline to week 6, with a difference between the groups of 1.1 points (95% CI, 0.4 to 1.8, P = .002) at week 18. Compared with SILM, ILM treatment resulted in a non-significant reduction in the BFI score (0.4; 95% CI, -0.2 to 0.9, P = .206) from baseline to week 6, while the between-group difference was significant at week 18 (0.7; 95% CI, 0.2 to 1.3, P = .014). No serious adverse events were reported. Conclusion While ILM was found to be safe and to significantly reduce fatigue compared with WLC, its promising efficacy against the sham control needs to be verified in future adequately powered trials. Trial registration Clinicaltrials.gov: NCT04144309. Registered 12 June 2018.

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Section: Discussionsupporting

confidence: 86%

Infrared laser moxibustion for cancer-related fatigue in breast cancer survivors: a randomized controlled trial

Mao,

Jin,

Xie

et al. 2024

Breast Cancer Res

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“…Some studies point out that phlegm and turbidity are mainly formed due to the deficiency of yang in the spleen and stomach and the malfunction of healthy transportation, and the pathogenesis of this type of vertigo is the deficiency of yang and yin, and the original deficiency and the symptoms are real, while phlegm and beverages are yin evils, which condense when they get cold and dissolve when they get warm. Moxibustion [ 9 ] and ear acupressing bean therapy [ 10 ] are the treasures of Chinese medicine, and research on moxibustion and ear acupressing bean therapy for vertigo has been in constant development in recent years. Studies [ 11 , 12 ] have shown that stimulating the corresponding response points and acupuncture points in the auricle can help regulate the qi and blood of the internal organs, balance yin and yang, unblock the meridians, and tonify the kidneys and strengthen the spleen, thus achieving a calming and tranquilizing effect and stopping dizziness.…”

Section: Introductionmentioning

confidence: 99%

Observation on the Efficacy of Moxibustion Combined with Ear Acupoint Pressing Beans in Treating Patients with Phlegm Stasis Syndrome Vertigo

Liu

Luo

Wang

et al. 2022

Emergency Medicine International

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Objective. The aim of this study is to investigate the efficacy of moxibustion combined with an ear acupoint pressing bean in the treatment of patients with phlegm stasis syndrome vertigo. Methods. 60 patients with vertigo identified as phlegm stasis syndrome who were hospitalized in our department from May 2020 to May 2021 were selected and divided into a control group and a treatment group of 30 cases each according to the random number method. The control group was treated with conventional treatment and care, and the treatment group was treated with moxibustion combined with ear acupressing beans on top of the conventional group. The treatment effects, the dizziness disorder inventory (DHI), Pittsburgh sleep quality index (PSQI), Hamilton anxiety score (HAMA), TCM symptom score, and blood flow parameters (left vertebral artery flow velocity (LVA), right vertebral artery flow velocity (RVA), and basilar artery flow velocity (BA)) of the two groups were compared with each other during and after the treatment. Results. After implementation, the treatment efficiency of the treatment group was higher than that of the control group, and the treatment group had lower PSQI, HAMA, and DHI scores as well as TCM symptom scores such as vertigo, head heavy as a wrap, chest tightness, and nausea and vomiting than the control group ( P < 0.05 ). In addition, LVA, RVA, and BA were all higher in the treatment group than in the control group after treatment ( P < 0.05 ). Conclusion. Moxibustion combined with ear acupoint pressing bean treatment can clearly improve patients’ sleep quality, psychological state, relieve patients’ various symptoms caused by vertigo, improve blood flow parameters, and have better efficacy in the treatment of phlegm stasis syndrome vertigo.

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“…Such as, moxibustion can inhibit nausea and vomiting after chemotherapy [ 28 , 29 ]. In addition, moxibustion can also be used to treat cancer-related fatigue [ 30 ]. The mechanism of moxibustion therapy for cancer is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y

Gao

Cai

et al. 2022

Neurochem Res

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Eucalyptol (1.8-cineole), an active component in traditional Chinese medicine Artemisia argyi for moxibustion. Previous studies have shown that eucalyptol has anti-tumor effects on leukemia and colon cancer. Nonetheless, the effect and mechanism of eucalyptol on neuroblastoma remains unclear. In the present study, we intended to reveal the effect and mechanism of eucalyptol treatment on the neuroblastoma cell line SH-SY5Y through transcriptome analysis. In the group treated with eucalyptol, 566 brain genes were up-regulated, while 757 genes were down-regulated. GO function analysis showed that positive regulation of cell cycle was down-regulated in biological processes. Meanwhile, cancer-related pathways were identified in KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis, including pathways in cancer, PI3K-Akt signaling pathway, cAMP signaling pathway, TGF-beta signaling pathway, Hippo signaling pathway, p53 signaling pathway, and additional pathways. Furthermore, we found a key gene, such as MYC, by constructing a network of cancer related pathways with differentially expressed genes and transcription factor analysis. In conclusion, our research indicates that MYC might play a central role in the anit-tumor mechanisms of eucalyptol.

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Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 25 publications

References 50 publications

Infrared laser moxibustion for cancer-related fatigue in breast cancer survivors: a randomized controlled trial

Infrared laser moxibustion for cancer-related fatigue in breast cancer survivors: a randomized controlled trial

Observation on the Efficacy of Moxibustion Combined with Ear Acupoint Pressing Beans in Treating Patients with Phlegm Stasis Syndrome Vertigo

Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y

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