Moxidectin residues in tissues of lambs submitted to three endoparasite control programs

Fernandes, Maria Ângela Machado; Gilaverte, Susana; Bianchi, Michele Dell; Silva, Cláudio José Araújo da; Molento, Marcelo Beltrão; Reyes, Felix G. R.; Monteiro, Alda Lúcia Gomes

doi:10.1016/j.rvsc.2017.07.010

Cited by 15 publications

(12 citation statements)

References 17 publications

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“…In equids, the control of gastrointestinal nematodes is mainly based on the use of synthetic drugs, such as macrocyclic lactones and benzimidazoles [3]. However, the use of drugs for the control of GIN that can be excreted in milk or that can persist in treated animals is limited in dairy donkey farms [4,5,6], thus there is a need to develop new and alternative control methods.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anthelmintic Activity of Saponins Derived from Medicago spp. Plants against Donkey Gastrointestinal Nematodes

Maestrini

Tava²,

Mancini

et al. 2019

Veterinary Sciences

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With the aim to find new effective natural compounds for the control of nematodes, the in vitro anthelminthic properties of purified 1% saponins showing different chemical compositions and derived from Medicago sativa (MS), Medicago arborea (MA), Medicago polymorpha cultivar ‘Santiago’ (MPS), M. polymorpha cultivar ‘Anglona’ (MPA), and 1% prosapogenins from M. sativa (MSp), were evaluated and compared. As a source of nematode eggs, pooled fresh fecal samples taken from dairy donkeys naturally infected by gastrointestinal nematodes were used. From fecal samples, eggs were recovered, suspended in deionized water, and used immediately in the bioassay (egg hatch test). The activity of the tested compounds was compared to positive (0.1% thiabendazole) and negative (deionized water and 1% DMSO) controls. All experiments were repeated in triplicate and the obtained data were statistically analyzed. All the tested plant compounds caused a significant (p < 0.05) inhibition of nematode egg hatching (>80%). Moreover, all saponins and prosapogenins showed in vitro anthelmintic properties statistically comparable to that of the reference drug (p < 0.05), except for MPS extract. Obtained results showed that the different Medicago saponins evaluated in this study possess high anthelmintic properties against gastrointestinal nematodes of dairy donkeys, although to a different extent depending on their composition.

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Section: Introductionmentioning

confidence: 99%

In Vitro Anthelmintic Activity of Saponins Derived from Medicago spp. Plants against Donkey Gastrointestinal Nematodes

Maestrini

Tava²,

Mancini

et al. 2019

Veterinary Sciences

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“…Sabendo que no Brasil o desafio parasitário é constante e que o regime de tratamento em animais de produção é realizado em quase sua totalidade com o uso de químicos e em intervalos curtos (< 90 dias), a IVM que alcança o ambiente irá apresentar grande acúmulo, antes mesmo da sua degradação. No Paraná, Fernandes et al (2017), determinaram que ovinos que não receberam moxidectina, uma macrolactona semelhante a IVM, apresentaram traços deste químico no fígado e na gordura, após pastejarem na mesma área de animais tratados com a dose recomendada pelo fabricante. Os autores apresentaram a hipótese de que esta contaminação ambiental possa ser estendida para outros animais que dividem a área dos ovinos, incluindo herbívoros e roedores selvagens.…”

Section: (Figura 3)unclassified

Ivermectina e Saúde Única: reposicionamento e a preocupação com o meio ambiente

Molento

2021

Rev. Educ. Cont. Med. Vet. Zootec.

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O descobrimento, o sucesso comercial e uso social da ivermectina (IVM) sempre foram mundialmente reconhecidos e deu aos seus autores o prêmio Nobel de Medicina/Fisiologia em 2015. Sua exclusiva ação endectocida e segurança, permitiram sua imediata integração em vários protocolos sanitários para praticamente todas as espécies animais, incluindo humanos. Entretanto, uso da IVM em larga escala e em alta frequência acarretou a seleção de parasitos resistentes. Como um produto multialvo, a IVM está sendo pesquisada, reposicionada, para atuar contra o vírus SARS-CoV-2. Os cuidados ambientais também devem ser considerados, pois a eliminação ambiental da IVM pode afetar ecossistemas aquáticos e comunidades com baixo desenvolvimento social, com pouco acesso a rede de esgoto e água tratada. A IVM pode ser considerada um dos melhores exemplos de medicamentos para atuar na Saúde Única, uma vez que tenhamos o objetivo de mitigar problemas sociais, em humanos, animais e nos ecossistemas.

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“…One distinctive group of anthelmintics is the macrocyclic lactones (ML) that act against arthropods and gastrointestinal nematodes (Fernandes et al, 2017), and account for approximately 80% of the veterinary market (Prichard and Geary, 2019). Manning et al (2018) related that are poorly metabolized and pass relatively unchanged into the dung of treated animals.…”

Section: Introductionmentioning

confidence: 99%

“…Moxidectin (MOX) is a milbemycin drug that belongs to the macrocyclic lactones (ML). It bioaccumulates in the animal body, stored mainly in the liver and adipose tissue (Fernandes et al, 2017), and it is excreted in the faeces for a long period (Hentz et al, 2019), and could eventually become an environmental and principally soil contaminant.…”

Section: Introductionmentioning

confidence: 99%

Does faeces excreted by moxidectin-treated sheep impact coprophagous insects and the activity of soil microbiota in subtropical pastures?

Hentz,

Reyes,

Kaschuk

et al. 2023

Preprint

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Moxidectin (MOX) is used to control helminth parasites in ruminant livestock being released through faeces into the environment. We aimed at evaluating the impact of MOX-contaminated sheep feces on soil coprophagous insects, microbial biomass, and activity. In a field experiment, faeces from MOX-treated rams (subcutaneous dose of 0.2 mg kg-1 body weight) and faeces from non-treated rams were placed on an animal-free pasture, protected or not from rain, for 88 days. Coprophagous insects were captured, identified, and counted, while N mineralization, and C e N contents were monitored. In a controlled experiment, faeces from non-treated animals were amended with MOX concentrations ranging from 75 to 3,000 ng MOX kg-1 faeces, mixed with soil from an animal-free pasture, and incubated for 28 days. Soil microbial biomass, respiration, and culture-microbe counting were determined. Diptera, Hymenoptera, Isoptera, and Coleoptera were equally found in faeces from both MOX-treated and non-treated animals. Faeces from MOX-treated animals had more N and degraded faster than those from non-treated animals. Even the lowest MOX concentration decreased soil microbial biomass, respiration, and N mineralization. Despite not harming coprophagous insects, the addition of MOX to feces from drug-free sheep has a negative impact on soil microbial biomass and activity.

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Moxidectin residues in tissues of lambs submitted to three endoparasite control programs

Cited by 15 publications

References 17 publications

In Vitro Anthelmintic Activity of Saponins Derived from Medicago spp. Plants against Donkey Gastrointestinal Nematodes

In Vitro Anthelmintic Activity of Saponins Derived from Medicago spp. Plants against Donkey Gastrointestinal Nematodes

Ivermectina e Saúde Única: reposicionamento e a preocupação com o meio ambiente

Does faeces excreted by moxidectin-treated sheep impact coprophagous insects and the activity of soil microbiota in subtropical pastures?

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