Moxifloxacin as Postoperative Prophylaxis for<i>Enterococcus faecalis</i>-Induced Endophthalmitis After Cataract Surgery in Aphakic Rabbits

Tasaka, Yoshitaka; Suzuki, Takashi; Kawasaki, Shiro; Uda, Takahiro; Mito, Tsuyoshi; Uno, Toshihiko; Ohashi, Yuichi

doi:10.1089/jop.2012.0149

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…epidermidis (MRSE) infections [ 14 , 15 ]. However, it is widely known that the misuse, overuse, or prophylactic use of these new antibiotics can result in antimicrobial resistance, which presents a serious problem [ 16 – 18 ]. In fact, there are now confirmed reports of a resistance to treatment with vancomycin [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The trend of resistance to antibiotics for ocular infection of Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium compared with 10-years previous: A retrospective observational study

Deguchi¹,

Kitazawa

Kayukawa³

et al. 2018

PLoS ONE

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ObjectiveTo retrospectively identify epidemiological trends of infection on the ocular surface and investigate trends of resistance to bacterial antibiotics compared with 10-years previous for Staphylococcus aureus, coagulase-negative staphylococci (CNS), and Corynebacterium in Japan.Materials and methodsBacterial isolate samples were collected from the conjunctival sacs of eyes afflicted with conjunctivitis, keratitis, dacryocystitis, and hordeolum from September 2004 through November 2005 (n = 145 isolates) and September 2014 through November 2015 (n = 195 isolates) at the Baptist Eye Institute, Kyoto, Japan. The prevalence of methicillin-resistant S. aureus (MRSA), methicillin-resistant CNS (MR-CNS), and fluoroquinolone-resistant Corynebacterium were examined, and susceptibility of isolated bacteria to levofloxacin (LVFX), cefmenoxime (CMX), chloramphenicol (CP), erythromycin (EM), vancomycin (VCM), and arbekacin (ABK) were compared between both time periods using the disc susceptibility method.ResultsOver the 10-year period from initial to final examination, the prevalence of MRSA and MR-CNS significantly decreased from 52% to 22% (P < 0.05) and from 47% to 25% (P < 0.05), respectively, yet there was no change in the prevalence of fluoroquinolone-resistant Corynebacterium (60% and 54%; P = 0.38). Antibiotic-resistance trend analysis revealed that susceptibility to antibiotics in 2014–2015 was similar to that in 2004–2005. MRSA and MR-CNS were susceptible to CP (88%), VCM (100%), and ABK (100%), while fluoroquinolone-resistant Corynebacterium was susceptible to CMX (100%), VCM (100%), and ABK (96%).ConclusionThe prevalence of MRSA and MR-CNS significantly decreased between the two time periods, yet more than 50% of the Corynebacterium isolates were still resistant to LVFX. Although no increase in bacterial resistance to antibiotics was found, a cautionary use of fluoroquinolone eye drops should be considered.

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Section: Introductionmentioning

confidence: 99%

The trend of resistance to antibiotics for ocular infection of Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium compared with 10-years previous: A retrospective observational study

Deguchi¹,

Kitazawa

Kayukawa³

et al. 2018

PLoS ONE

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“…Moreover, Pinheiro et al (2004) suggested the use of moxifloxacin as an alternative therapy for penicillin-allergic patients. Similar to this study, they encountered that E. faecalis was susceptible to this antimicrobial in all cases, a finding also supported by some other authors regarding E. faecalis infections (Fass 1993, Mather et al 2002, Tasaka et al 2013.…”

Section: Enterococcus Faecalissupporting

confidence: 92%

Investigação dos perfis proteômico e microbiológico e da suscetibilidade antimicrobiana de bactérias específicas em infecções endodônticas

Amanda Francisco

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Ata da defesa, assinada pelos membros da Comissão Examinadora, consta no SIGA/Sistema de Fluxo de Dissertação/Tese e na Secretaria do Programa da Unidade. DEDICATÓRIA Dedico este trabalho aos meus pais Kátia e César Francisco e irmã PatríciaFrancisco, minha querida família. Considero-me abençoada pela base em que me edifiquei e não consigo pensar em exemplos maiores de honestidade, caráter e amor.Minha admiração e gratidão por vocês é imensa. AGRADECIMENTOSA Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) pela concessão da bolsa de doutorado no país, processo nº 2017/16516-7 e pela bolsa de estágio no exterior, processo nº 2018/21553-1.

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“…Moxifloxacin was also as effective as vancomycin in the treatment of experimental S. aureus endophthalmitis (Ermis et al, 2007). Moxifloxacin was effective in treating experimental B. cereus (Sakalar et al, 2011) and S. epidermidis (Ermis et al, 2005) endophthalmitis, and was beneficial when used prophylactically prior to intraocular infection with E. faecalis (Tasaka et al, 2013) and S. aureus (Kowalski et al, 2004). …”

Section: Experimental Models: Bench To Bedsidementioning

confidence: 99%

Modeling intraocular bacterial infections

Astley

Coburn

Parkunan

et al. 2016

Progress in Retinal and Eye Research

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Bacterial endophthalmitis is an infection and inflammation of the posterior segment of the eye which can result in significant loss of visual acuity. Even with prompt antibiotic, anti-inflammatory and surgical intervention, vision and even the eye itself may be lost. For the past century, experimental animal models have been used to examine various aspects of the pathogenesis and pathophysiology of bacterial endophthalmitis, to further the development of anti-inflammatory treatment strategies, and to evaluate the pharmacokinetics and efficacies of antibiotics. Experimental models allow independent control of many parameters of infection and facilitate systematic examination of infection outcomes. While no single animal model perfectly reproduces the human pathology of bacterial endophthalmitis, investigators have successfully used these models to understand the infectious process and the host response, and have provided new information regarding therapeutic options for the treatment of bacterial endophthalmitis. This review highlights experimental animal models of endophthalmitis and correlates this information with the clinical setting. The goal is to identify knowledge gaps that may be addressed in future experimental and clinical studies focused on improvements in the therapeutic preservation of vision during and after this disease.

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Moxifloxacin as Postoperative Prophylaxis forEnterococcus faecalis-Induced Endophthalmitis After Cataract Surgery in Aphakic Rabbits

Abstract: Early ocular instillation of MFLX delays retinal damage compared with LVFX when used to treat E. faecalis-induced endophthalmitis after cataract surgery.

Cited by 6 publications

References 33 publications

The trend of resistance to antibiotics for ocular infection of Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium compared with 10-years previous: A retrospective observational study

The trend of resistance to antibiotics for ocular infection of Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium compared with 10-years previous: A retrospective observational study

Investigação dos perfis proteômico e microbiológico e da suscetibilidade antimicrobiana de bactérias específicas em infecções endodônticas

Modeling intraocular bacterial infections

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