Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode

Abstract

It appeared that either the carbon paste or the screen-printed carbon electrodes that were modified with gold nanoparticles (AuNPs) gave rise to the largest current responses after a rapid screening of various nanomaterials as modifiers of carbon composite electrodes in view of designing an electrochemical sensor for Moxifloxacin Hydrochloride (Moxi). The screen-printed electrode (SPE) support was preferred over the carbon paste one for its ability to be used as disposable single-use sensor enabling the circumvention of the problems of surface fouling encountered in the determination of Moxi. The response of AuNPs modified SPE to Moxi was investigated by cyclic voltammetry (CV) (including the effect of the potential scan rate and the pH of the medium), chronoamperometry, and differential pulse voltammetry (DPV) after morphological and physico-chemical characterization. DPV was finally applied to Moxi detection in phosphate buffer at pH 7, giving rise to an accessible concentration window ranging between 8 µM and 0.48 mM, and the detection and quantification limits were established to be 11.6 µM and 38.6 µM, correspondingly. In order to estimate the applicability of Moxi identification scheme in actual trials, it was practiced in a human baby urine sample with excellent recoveries between 99.8 % and 101.6 % and RSDs of 1.1–3.4%, without noticeable interference.

Tailoring Terpesomes and Leciplex for the Effective Ocular Conveyance of Moxifloxacin Hydrochloride (Comparative Assessment): In-vitro, Ex-vivo, and In-vivo Evaluation

“…2 Moxifloxacin Hydrochloride (MOX) is an antimicrobial of low toxicity and has an effect against gram (+ve), and gram (-ve) bacteria. 3 MOX is either given as an intracameral injection or topically. However, the intracameral injection may cause corneal endothelial toxicity and toxic anterior segment syndrome.…”

Electrochemical determination of vitamin B6 (pyridoxine) by reformed carbon paste electrode with iron oxide nanoparticles

“…6) can be represented by the linear equation: Figure 6 inset shows the corresponding differential pulse curves for increasing vitamin B 6 concentrations (from 8.88 up to 1000.0 µM) in 0.1 M of PBS (pH 6.0) and scan rate 0.01 Vs −1 using IONCPE. Limit of quantification (LOQ) and limit of detection (LOD) were calculated by the following equations [72]:…”

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

“…Carboxylated MWCNTs decorated with AuNPs using ethylenediamine as a cross-linker were drop-casted on SPE and applied for electrochemical determination of amoxicillin combining the good electron transfer property and catalytic property of the two nanomaterials [ 276 ]. AuNPs have been electrochemically deposited on SPE (with spherical shape and size between 13–58 nm) and applied for moxifloxacin hydrochloride detection with good performance [ 277 ]. A low-cost SPE modified with fullerene, reduced graphene oxide and nafion has been elaborated in order to evaluate metronidazole with high stability, repeatability, reproducibility, fast response and low cost, performance which is due to the electrocatalytic synergic effect of the nanomaterials [ 278 ].…”