Moyamoya disease complicated by Graves’ disease and type 2 diabetes mellitus: Report of two cases

Suzuki, Sakiko; Mitsuyama, Tetsuryu; Horiba, Ayako; Fukushima, Sayaka; Hashimoto, Naotake; Kawamata, Takakazu

doi:10.1016/j.clineuro.2010.11.022

Cited by 24 publications

(21 citation statements)

References 35 publications

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“…These results indicate that not only is unilateral MMD associated with autoimmune disease, but bilateral MMD is as well, a conclusion that is consistent with findings of multiple previous studies. 2,13,[15][16][17]19,23 More importantly, we found that unilateral MMD was more likely associated with autoimmune disease than bilateral MMD. Different pathogenetic mechanisms may underlie moyamoya vessel formation in unilateral and bilateral MMD.…”

Section: Discussionmentioning

confidence: 49%

“…Additionally, the authors of these studies hypothesized that there is a potential autoimmune component to the pathogenesis of moyamoya vasculopathy. 2,13,[15][16][17]19,23 In this study, we found that unilateral MMD may be more likely to be associated with autoimmune disease than bilateral MMD. Moreover, these findings suggest that unilateral MMD may be more frequently observed with autoimmune comorbidities.…”

Section: Discussionmentioning

confidence: 62%

“…Moyamoya disease presenting concurrently with other specific autoimmune diseases has also been described in the literature. 2,8,9,13,16,19,23 In this study, autoimmune thyroid diseases, all other autoimmune diseases, and other comorbidities tended to have higher prevalence rates in unilateral MMD patients than in bilateral MMD patients. Nevertheless, no significant differences were observed between unilateral and bilateral MMD with regard to each specific concurrent autoimmune disease, including GD, HT, Type 1 diabetes mellitus, and all other evaluated autoimmune diseases.…”

Section: Discussionmentioning

confidence: 85%

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Increased prevalence of autoimmune disease in patients with unilateral compared with bilateral moyamoya disease

Chen

Liu

Zhou

et al. 2016

JNS

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M oyamoya vasculopathy (MMV) is a disorder that is characterized by stenosis or occlusion of the terminal internal carotid artery (ICA) and the proximal portion of the anterior and/or middle cerebral arteries. Additionally, it is accompanied by net-like collateral vessel formations, which are termed the "moyamoya" vessels.14,18 Moyamoya disease (MMD) is defined by the presence of bilateral MMV with an unknown etiology or the presence of unilateral MMV at 1 side with obvious terminal contralateral ICA stenosis.4 Unilateral MMD is defined by typical angiographic evidence of MMD unilaterally with normal or equivocal contralateral findings. 4The concept that unilateral MMD is an early form of bilateral MMD remains controversial, and the pathogenesis of moyamoya disorders is not fully understood. 7,11,14,18 MMD has been reportedly associated with various entities. 2,8,9,13,16,24 Analysis of the coexisting diseases that occur with moyamoya may be helpful in exploring moyamoya pathogeneses. Several reports have noted MMD in association with autoimmune diseases, including autoim- obJective This study explored whether there were differences between the autoimmune disease prevalence rates in unilateral and bilateral moyamoya disease (MMD). methods The authors performed a retrospective review of data obtained from the medical records of their hospital, analyzing and comparing the clinical characteristics and prevalence rates of all autoimmune diseases that were associated with unilateral and bilateral MMD in their hospital from January 1995 to October 2014. results Three hundred sixteen patients with bilateral MMD and 68 with unilateral MMD were identified. The results indicated that patients with unilateral MMD were more likely to be female than were patients with bilateral MMD (67.6% vs 51.3%, p = 0.014, odds ratio [OR] 1.99). Overall, non-autoimmune comorbidities tended to be more prevalent in the unilateral MMD cases than in the bilateral MMD cases (17.6% vs 9.8%, p = 0.063, OR 1.97, chi-square test). Autoimmune thyroid disease and other autoimmune diseases also tended to be more prevalent in the unilateral MMD cases than in the bilateral MMD cases (19.1% vs 10.8%, p = 0.056, OR 1.96 and 8.8% vs 3.5%, p = 0.092, OR 2.77, respectively, chi-square test). The overall autoimmune disease prevalence in the unilateral MMD cases was significantly higher than in the bilateral MMD cases (26.5% vs 13.6%, p = 0.008, OR 2.29, 95% CI 1.22-4.28, chi-square test). Multiple logistic regression analysis showed that autoimmune disease was more likely to be associated with unilateral than with bilateral MMD (p = 0.039, OR 10.91, 95% CI 1. 13-105.25). coNclusioNs This study indicated a higher overall autoimmune disease prevalence in unilateral than in bilateral MMD. Unilateral MMD may be more associated with autoimmune disease than bilateral MMD. Different pathogenetic mechanisms may underlie moyamoya vessel formation in unilateral and bilateral MMD.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

Increased prevalence of autoimmune disease in patients with unilateral compared with bilateral moyamoya disease

Chen

Liu

Zhou

et al. 2016

JNS

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“…13,56,64,72) However, these studies have indirectly proved the correlation between abnormalities of the immune system and moyamoya disease. Indeed, it is conceivable that the true genetic triggers of moyamoya disease are close to the abnormalities seen in HLA alleles disclosed.…”

Section: Proteomicsmentioning

confidence: 99%

Review of Past Research and Current Concepts on the Etiology of Moyamoya Disease

Houkin

Ito

Sugiyama

et al. 2012

Neurol. Med. Chir.(Tokyo)

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Research on moyamoya disease has progressed remarkably in the past several decades. Indeed, many new facts concerning the epidemiology of the disease have been revealed and surgical treatments have been drastically improved. However, despite extensive research, the mechanism of moyamoya disease is still unknown. Consequently, the cardinal treatment of this disease has not yet been developed. For further clarification of its etiology, innovative studies are therefore indispensable. The aim of this paper is to review research on the pathogenesis of moyamoya disease to identify milestones in the direction of its true solution. Many hypotheses of the pathogenesis of moyamoya disease have been proposed in the past half century, including infection (viral and bacterial), autoimmune disorders, proteins abnormality, and gene abnormality. Some of these are now considered to be historical achievements. Others, however, can be still subjected to contemporary research. Currently, several genetic abnormalities are considered to offer the most probable hypothesis. In addition, interesting papers have been presented on the role of the endothelial progenitor cell on the pathogenesis of moyamoya disease. Intuitively, however, it appears that a single theory cannot always explain the pathogenesis of this disease adequately. In other words, the complex mechanism of several factors may comprehensively explain the formation of moyamoya disease. The``double hit hypothesis'' is probably the best explanation for the complicated pathology and epidemiology of this disease.

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“…Moyamoya hastalığının diğer tıbbi durumlarla birlikteliği, Moyamoya sendromu olarak adlandırılır (8,(17)(18)(19)(20)(21)(22)(23)(24)(25). Bizim olgularımızın da 4'ünde hipertansiyon, 2'sinde hidrosefalinin eşlik ettiği korpus kallosum disgenezisi ve agenezisi tespit edilirken, birer hastada diyabet, ponsta glioma ve hipertiroidi saptanmış ve bu veriler literatürle uyumlu olarak değerlendirilmiştir.…”

Section: Materyal Ve Methodunclassified

The retrospective evaluation of the patients diagnosed moyamoya disease at Uludağ University Hospital between 2006-2010

Tolgay¹,

Cantürk²,

Bakar³

et al. 2011

Türk Beyin Damar Hast Derg

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Moyamoya disease complicated by Graves’ disease and type 2 diabetes mellitus: Report of two cases

Cited by 24 publications

References 35 publications

Increased prevalence of autoimmune disease in patients with unilateral compared with bilateral moyamoya disease

Increased prevalence of autoimmune disease in patients with unilateral compared with bilateral moyamoya disease

Review of Past Research and Current Concepts on the Etiology of Moyamoya Disease

The retrospective evaluation of the patients diagnosed moyamoya disease at Uludağ University Hospital between 2006-2010

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