2010
DOI: 10.5507/bp.2010.024
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Moyamoya Disease Is Associated With Endothelial Activity Detected by Anti-Nestin Antibody

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Cited by 19 publications
(15 citation statements)
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“…17 It is well known that strong contrast enhancement of the arterial wall suggests an increase in the vascular supply and increased endothelial permeability, which promotes entry of the contrast agent into the extravascular space. 18 Chmelova et al 19 found a higher expression of both angiogenetic factors in intima and vascular endothelial growth factor in the endothelium of Moyamoya-affected arteries than normal arteries. Nestin, a marker of newly formed endothelial cells was expressed in the Moyamoya-affected vessels.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…17 It is well known that strong contrast enhancement of the arterial wall suggests an increase in the vascular supply and increased endothelial permeability, which promotes entry of the contrast agent into the extravascular space. 18 Chmelova et al 19 found a higher expression of both angiogenetic factors in intima and vascular endothelial growth factor in the endothelium of Moyamoya-affected arteries than normal arteries. Nestin, a marker of newly formed endothelial cells was expressed in the Moyamoya-affected vessels.…”
Section: Discussionmentioning
confidence: 99%
“…20 Thus, it can be presumed that an active angiogenetic milieu prevails in the enhanced vessels in patients with MMD. 19 Similar to the atherosclerotic process in the extracranial vessels where concentric and circumferential wall enhancements suggest an inflammatory response due to increased macrophage infiltration and neovascularity, the enhancement in Moyamoya vessels may be considered to represent an active angiogenetic process and inflammatory response.…”
Section: Discussionmentioning
confidence: 99%
“…Disappearance of the moyamoya (disappearance of the moyamoya vessels, with cerebral blood flow derived only from the external carotid artery and the vertebrobasilar artery systems) endothelial cells (48), and that the endometrial thickening caused by fibrous cell hyperplasia of the arterial intima is the cause of arterial stenosis and occlusion (3). Guo et al (49) reported that arterial stenosis and occlusion of familial MMD may be due to smooth muscle tissue hyperplasia associated with a mutation in the actin, α2, smooth muscle, aorta gene.…”
Section: Pathology Of MMDmentioning
confidence: 99%
“…Chmelova et al . found that angiogenetic factors in intima and VEGF in the endothelium of moyamoya-affected arteries were higher expressed than normal17. This suggests an active angiogenetic process in the enhanced vessel wall in patients with MMV.…”
Section: Discussionmentioning
confidence: 92%