Moyamoya‐induced paroxysmal dyskinesia

Gonzalez‐Alegre, Pedro; Ammache, Zakaria; Davis, Patricia H.; Rodnitzky, Robert L.

doi:10.1002/mds.10483

Cited by 49 publications

(24 citation statements)

References 23 publications

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“…34 Although MRI/MRA imaging is warranted to exclude potential major vascular etiologies such as Moyamoya syndrome or vascular occlusion, such studies cannot definitively exclude involvement of small vessels. 35 However, autopsy data from 2 cases in our database have not revealed obvious large, medium, or small vessel pathology in the central nervous system.…”

Section: Discussionmentioning

confidence: 69%

Alternating Hemiplegia of Childhood: Early Characteristics and Evolution of a Neurodevelopmental Syndrome

Sweney¹,

et al. 2009

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This descriptive analysis of a large cohort of children indicates that paroxysmal ocular movements are an early, highly suggestive symptom, followed by paroxysmal episodes of focal dystonia or flaccid, alternating hemiplegia in early infancy in the majority of subjects. Current challenges in diagnosis and management contribute to poor outcomes. Early diagnosis and multicenter collaboration are needed to facilitate trials to identify more effective therapies.

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Section: Discussionmentioning

confidence: 69%

Alternating Hemiplegia of Childhood: Early Characteristics and Evolution of a Neurodevelopmental Syndrome

Sweney¹,

et al. 2009

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“…differential diagnosis of persistent or paroxysmal chorea. 3 The pathology is localized to the basal ganglia, as chorea is a known manifestation of ischemia in the basal ganglia. 2 In moyamoya disease, the prominent collateral vessels in the basal ganglia are likely candidates for the pathological substrate in this manifestation of the disease.…”

Section: Discussionmentioning

confidence: 99%

Chorea in the clinical presentation of moyamoya disease: results of surgical revascularization and a proposed clinicopathological correlation

Ahn

Scott²,

Robertson

et al. 2013

PED

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Object Chorea is a movement disorder characterized by brief, irregular, involuntary contractions that appear to flow from 1 muscle to another. There are a limited number of reports in the literature that have linked moyamoya disease and chorea. The authors describe their experience in treating moyamoya disease in patients in whom chorea developed as part of the clinical presentation. Methods The authors conducted a retrospective review of a consecutive series of 316 children who underwent pial synangiosis revascularization for moyamoya disease at the Boston Children's Hospital. Results Of 316 surgically treated patients with moyamoya disease, 10 (3.2%; 6 boys and 4 girls) had chorea as a part of their presentation. The average age at surgical treatment was 9.9 years (range 3.8–17.9 years). All patients had evidence of hypertrophied lenticulostriate collateral vessels through the basal ganglia on preoperative angiography and/or MRI on affected sides. Two patients had cystic lesions in the basal ganglia. Nine patients underwent bilateral craniotomies for pial synangiosis, and 1 patient underwent a single craniotomy for unilateral disease. Follow-up was available in 9 patients (average 50.1 months). The mean duration of chorea was 1.36 years (range 2 days to 4 years), with resolution of symptoms in all patients. One patient developed chorea 3 years after surgical treatment, 4 patients had transient chorea that resolved prior to surgery, and 5 patients experienced resolution of the chorea after surgery (average 13 months). Conclusions The authors describe children with moyamoya disease and chorea as part of their clinical presentation. The data suggest that involvement of the basal ganglia by the hypertrophied collateral vessels contributes to the development of chorea, which can wax or wane depending on disease stage or involution of the vessels after revascularization surgery. In most patients, however, the chorea improves or disappears about 1 year after presentation.

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“…The different topography of each lesion in patients with hemichorea showed the importance of cortical-basal network in the development of movement disorders. The moyamoya disease is an uncommon cause of vascular chorea, it is an intracranial vasculopathy that evidences an ischemic lesion or, less commonly, hemorrhagic stroke of the basal ganglia [31]. …”

Section: Hemichorea-hemiballism Dystoniamentioning

confidence: 99%

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

Siniscalchi¹,

Gallelli²,

Labate³

et al. 2012

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Involuntary abnormal movements have been reported after ischaemic and haemorrhagic stroke. Post stroke movement disorders can appear as acute or delayed sequel. At the moment, for many of these disorders the knowledge of pharmacological treatment is still inadequate. Dopaminergic and GABAergic systems may be mainly involved in post-stroke movement disorders. This article provides a review on drugs commonly used in post-stroke movement disorders, given that some post-stroke movement disorders have shown a partial benefit with pharmacological approach.

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Moyamoya‐induced paroxysmal dyskinesia

Cited by 49 publications

References 23 publications

Alternating Hemiplegia of Childhood: Early Characteristics and Evolution of a Neurodevelopmental Syndrome

Alternating Hemiplegia of Childhood: Early Characteristics and Evolution of a Neurodevelopmental Syndrome

Chorea in the clinical presentation of moyamoya disease: results of surgical revascularization and a proposed clinicopathological correlation

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

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