MP-3 measurement of retinal sensitivity in macular hole area and its predictive value on visual prognosis

Wang, Zengyi; Qi, Yue; Liang, Xida; Yu, Yanping; Chen, Jinqiu; Wang, Jing; Liu, Xinxin; Liu, Wu

doi:10.1007/s10792-018-1032-x

Cited by 16 publications

(22 citation statements)

References 29 publications

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“…Retinal sensitivity within 4° and 10° behaved accordingly, equally rising from baseline to 1-month follow-up in both Groups (Table 2 ) while only the Cover Group further improved at 3-months, reaching a significant advantage. Wang et al also reported a significant increase in retinal sensitivity after MH surgery and found that average retinal sensitivity measured at the very MH rim yielded the highest correlation to final BCVA, similarly to our result within the central 4° 10 .…”

Section: Discussionsupporting

confidence: 89%

Inverted ILM-flap techniques variants for macular hole surgery: randomized clinical trial to compare retinal sensitivity and fixation stability

Cacciamani

Gelso²,

Nicola

et al. 2020

Sci Rep

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To report closure rate, Best Corrected Visual Acuity (BCVA), Retinal Sensitivity (RS) and Fixation Stability (FS) of idiopathic Macular Holes (MH) randomized to Cover Group (CG) or Fill Group (FG) of the Inverted Internal Limiting Membrane (ILM) flap surgical procedure. Twenty-eight patients were randomized (1:1) to receive a vitrectomy with either Cover or Fill ILM flap technique. All patients underwent BCVA, RS and FS assessment at baseline, 1-month and 3-months after surgery. MH closed in all patients. BCVA rose from 20/100 (baseline) to 20/33 (1-month) in both groups, to 20/28 in CG versus 20/33 in FG (3-months) (p < 0.05). The central 4° RS rose from 11.5 and 12 dB to 19 and 19.5 dB (1-month) and to 22 and 20 dB (3-months), respectively, in CG and FG (p < 0.001). The central 10° RS rose from 11 and 15 dB to 22 and 20 dB (1-month) and to 23 and 20 dB (3-months), respectively, in CG and FG (p < 0.001). FS increased significantly more in CG. CG improved significantly more than FG in terms of BCVA, RS and FS. The average MH diameter was relatively small (397 µm); larger MHs may behave differently. Trial registration: Trial Registry: https://www.clinicaltrials.gov; Identifier: NCT04135638. Registration date 22/10/2019.

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Section: Discussionsupporting

confidence: 89%

Inverted ILM-flap techniques variants for macular hole surgery: randomized clinical trial to compare retinal sensitivity and fixation stability

Cacciamani

Gelso²,

Nicola

et al. 2020

Sci Rep

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“…MMS and the minimum linear diameter (MLD) were considered predictive factors for postoperative visual acuity in IMH patients in previous studies 14 . In this study, the correlation between preoperative MMS and MLD was statistically significant ( P = 2.96E−4, Spearman analysis), and both preoperative MMS and MLD were correlated with BCVA 3 months postoperatively (MMS: P = 0.02; MLD: P = 1.16E−4, respectively, Spearman analysis).…”

Section: Resultsmentioning

confidence: 99%

“…Both the microstructures of the macular area and the changes in fixation locations can affect postoperative visual acuity. Microperimetry is an essential technique for assessing the morphological and functional losses in macular pathologies 15 , 16 , and can provide retinal sensitivity and fixation stability for retinal function assessment 14 . Witha scanning laser ophthalmoscope (SLO), we can precisely measure retinal sensitivity and determine which part of the retina the patient is using for fixation 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Witha scanning laser ophthalmoscope (SLO), we can precisely measure retinal sensitivity and determine which part of the retina the patient is using for fixation 11 . MAIA has evolved into a robust tool for evaluating retinal function in recent years 14 , 17 . It can be used to map the location of scotomas and the results can be accurately plotted by correcting for eye movements.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics of fixation patterns and their relationship with visual function of patients with idiopathic macular holes after vitrectomy

Liu

Wang

Dong

et al. 2021

Sci Rep

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To analyze the relationships between the fixation location and the visual function of idiopathic macular hole (IMH) patients with macular integrity assessment (MAIA) examination preoperatively and 3 months postoperatively. This was a retrospective case analysis. Forty-three eyes of 43 patients diagnosed with IMH were included in this study. The best corrected visual acuity (BCVA) assessments, optical coherence tomography (OCT) and MAIA examinations were performed before surgery and 1 week, 1 month and 3 months after surgery. The relationships between MAIA parameters and visual acuity were assessed by correlation analysis. Grouping by fixation location with the foveola (2°) as the centre, the locations could be divided into five groups, including foveolar, temporal, nasal, inferior and superior fixation. The mean macular sensitivity (MMS) of the macular area was correlated with the BCVA in the IMH patients before and 3 months after surgery (before surgery P = 0.00, after surgery P = 0.00). The MMS could be used as a good indicator for evaluating visual function in IMH patients. There was a significant difference in fixation location before and after the operation (P = 0.01). The preoperative fixation location of IMH patients was mainly in the superior area, while postoperatively moved to the foveola and nasal areas. Paying attention to the changes of fixation locations in IMH patients may provide new clues for further improving postoperative visual function.

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“…Sborgia et al reported that both central macular sensitivity (within 4°) and macular sensitivity (within 12°) significantly improved in large macular hole after treatment of inverted ILM flap technique [28]. Wang et al recorded increase of macular hole sensitivity after successful ILM peeling surgery [29].…”

Section: Discussionmentioning

confidence: 99%

Functional evaluation with microperimetry in large idiopathic macular holes treated by a free internal limiting membrane flap tamponade technique

et al. 2020

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Background: Free internal limiting membrane (ILM) flap tamponade technique is an alternative choice for treating large idiopathic macular holes (IMHs). However, the functional recovery related to this surgical approach is not well-characterized. This study aimed to evaluate morphological and microperimetric outcomes 6 months after free ILM flap tamponade technique for large IMHs. Methods: Twenty-two patients (22 eyes) with large IMHs (minimal diameter > 400 μm) were retrospectively enrolled in this study. All patients underwent 23-gauge pars plana vitrectomy with ILM peeling and free ILM flap tamponade procedures. Snellen best-corrected visual acuity (BCVA), optical coherence tomography (OCT), and MP-1 microperimetry were measured at baseline and 6 months after surgery. Associations of postoperative BCVA with retinal sensitivity were detected. Results: Macular hole closure was achieved in 21 eyes (95.5%). Dislodgement of free ILM flap was found in non-closed eye. Mean logMAR BCVA improved from 1.10 ± 0.33 at baseline to 0.67 ± 0.32 at 6 months postoperatively (P < 0.001). The mean overall macular sensitivity and foveal fixation stability increased respectively from 8.58 ± 3.05 dB and 65.64 ± 17.28% before surgery to 11.55 ± 2.72 dB and 78.59 ± 13.00% at 6 months after surgery (P < 0.001). The mean change in foveal sensitivity (within 2°) was significantly greater than the change achieved for peri-foveal sensitivity (2°to 10°) by 1.50 ± 2.62 dB (P = 0.014). Linear regression analysis showed that postoperative logMAR BCVA was significantly associated with duration of symptom (B = 0.063, P = 0.001), preoperative logMAR BCVA (B = 0.770, P = 0.000), preoperative peri-foveal (B = − 0.065, P = 0.000) and foveal sensitivity (B = − 0.129, P = 0.000). Moreover, multiple regression model revealed that preoperative foveal sensitivity was independently associated with postoperative logMAR BCVA (B = − 0.430, P = 0.040). Conclusions: Vitrectomy combined with ILM peeling and free ILM flap tamponade technique results in effective morphological and functional recovery for large IMHs. Preoperative foveal sensitivity might be a prognostic indicator for postoperative BCVA.

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MP-3 measurement of retinal sensitivity in macular hole area and its predictive value on visual prognosis

Cited by 16 publications

References 29 publications

Inverted ILM-flap techniques variants for macular hole surgery: randomized clinical trial to compare retinal sensitivity and fixation stability

Inverted ILM-flap techniques variants for macular hole surgery: randomized clinical trial to compare retinal sensitivity and fixation stability

Characteristics of fixation patterns and their relationship with visual function of patients with idiopathic macular holes after vitrectomy

Functional evaluation with microperimetry in large idiopathic macular holes treated by a free internal limiting membrane flap tamponade technique

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