Mp05-04 Contrast-Enhanced Ultrasound (Ceus) and Elastography Techniques in the Evaluation of Unclear Scrotal Masses

Marcon, Julian; Trottmann, Matthias; D’Anastasi, Melvin; Mai, Vera; Rübenthaler, Johannes; Khoder, Wael; Stief, Christian G.; Reiser, Maximilian; Clevert, Dirk-André

doi:10.1016/j.juro.2016.02.1981

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“…In recent years, spleen elastography has been proposed as an alternative method to liver stiffness to predict the severity and prognosis of liver disease, detecting PH and predicting esophageal variances (6). Ultrasonographic (US) and magnetic resonance imaging (MRI) are the most common elastographic methods for the assessment of spleen stiffness (7). The results from several single studies have suggested the potential usefulness of spleen elastography in evaluating the risk of esophageal varices in subjects with PH or liver cirrhosis (8).…”

Section: Introductionmentioning

confidence: 99%

Spleen Stiffness on Magnetic Resonance Elastography for the Detection of Portal Hypertension: A Systematic Review and Meta-Analysis

Ma¹,

Qian²,

Zhang³

2022

ijph

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Background: Chronic liver disease, complicated by portal hypertension (PH), may alter the extra-hepatic hemodynamic condition and spleen stiffness (SS). We aimed to evaluate the diagnostic accuracy of MRI-based elastographic methods (MRE) for detecting PH. Methods: Seven studies were included with reference to SS with regard to the prediction of PH patients. Major outcomes considered for data extraction were diagnostic parameters for MRI for concluding mild PH, clinically significant PH and severe PH. PubMed, Scopus, Google Scholar, Cochrane and Science Direct databases were used to extract the published literature through to May, 2021Using the Rayyan Zotero and R softwares. Results: Out of 587 studies extracted, 7 were selected based on inclusion and exclusion criteria. A QUADAS-2 assessment showed that all studies were clear in terms of patient selection and reference standard. A funnel plot showed that all the selected studies were outliers, indicating a low level of accuracy for the studies included. Subgroup analysis, with reference to SS as a predictor of PH, revealed raw mean difference (RMD) of 7.78% (95% CI 5.23-10.34, P<0.01). The corresponding RMD observed for <60 years and >60 yr were 34.26% (95% CI 9.33- 59.20, I2=100%, T2=646.7688, P=0), and 46.92% (95% CI 20-59.33, I2=97%, T2=1003.023, P=0) respectively. The specificity and sensitivity noted for MRI in determining SS were 0.721 and 0.747, respectively with an area-under the curve of 0.788. The estimated random effect models for specificity and sensitivity were 0.938 and 0.842, respectively. Conclusion: The real-time MRE has acceptable specificity and sensitivity for diagnosing SS.

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Section: Introductionmentioning

confidence: 99%