Mp27-06  characteristics and Progression-Freesurvival of Afro-Caribbean Men With Metastatic Hormone-Sensitive Prostate Cancer (Mhspc) at the Time of Diagnosis

Abstract

and had persistent elevated prostate-specific antigen. Post-operative imaging and management strategies were collated. Probability of metastasis-free survival (MFS), prostate cancer specific survival (CSS) and overall survival (OS) among this cohort of men using Kaplan-Meier methods.RESULTS: We identified 258 patients meeting the elgibility criteria, of which 128 patients developed metastasis. The 5-year and 10-year MFS probability was 52% (95% CI 45%, 58%) and 38% (95% CI 29%, 47%), respectively. We identified 58 patients who died of any cause, 48 from disease. The 5 and 10-year survival probabilities from disease are 89% (95% CI 84%, 93%), and 68% (95% CI 58%, 76%), respectively; and from any cause are 87% (95% CI 81%, 91%), and 63% (95% CI 53%, 71%), respectively. Postoperative imaging was obtained for 77% of patients, of whom 87% had a negative scan. Post-operative treatment included hormonal deprivation in 88% of men, observation alone in 7%, adjuvant radiotherapy in 4%, and combined chemotherapy and hormonal therapy in 1%.CONCLUSIONS: In the absence of clear pre-existing data or guidelines, we highlight our experience of patients with nodal invasion and PSA persistence post-prostatectomy. We highlight compromised metastatases-free survival and overall survival. Further, we highlight the limited role for conventional imaging in this cohort.