Mp51-04 Association Between Testosterone, Vitamin D and Cardiovascular Risk

Abstract

INTRODUCTION AND OBJECTIVES: It has been well established that Vitamin D plays in an important role in bone metabolism, but within the last decade Vitamin D has been shown be associated with the inflammatory cascade as well as immune-modulating properties. Numerous studies have implicated low Vitamin D levels in increased overall mortality, cardiovascular (CV) and cancer mortality. In fact, Siadat et al showed that low serum 25-hydroxyvitamin D (VitD-25) is associated with prevalent coronary artery disease independent of CV risk factors. Studies have shown a complex relationship between vitamin D and androgen metabolism. To date, there is conflicting information regarding the association of vitamin D and androgen levels in men. In this abstract, we aim to show relationship between total testosterone (TT) and serum VitD-25 independent of CV risk among asymptomatic middle-aged men.METHODS: We evaluated 824 male participants in the World Trade Center (WTC)-CHEST program from January 2011 to June 2014. Blood samples were analyzed for various laboratory parameters including VitD-25 and total testosterone. Hypovitaminosis D is defined as VitD-25 less than 30.0 ng/L. We used the Framingham 10-year CV disease risk as a proxy for general CV risk.RESULTS: Insufficient VitD-25 was noted in 68.3% (563) of the participants. Only 11.4% (64) of those with insufficient VitD-25 took Vitamin D supplementation. Subjects with insufficient VitD-25 were significantly younger, and have higher BMI than those with normal VitD-25 (table). In subjects with hypovitaminosis D, TT was 319.66, b108.85 ng/L which was significantly lower than those with normal VitD-25 whose TT was 341.77, b132.36 (p ¼ 0.013). When adjusted for Framingham 10-year CV Disease risk, subjects with hypovitaminosis D still had significantly lower TT than those with normal TT (p ¼ 0.019) CONCLUSIONS: There is a significant association between hypovitaminosis D and total testosterone among this population of asymptomatic middle-aged men independent of cardiac risk. It is important to evaluate vitamin D levels in men having low total testosterone. INTRODUCTION AND OBJECTIVES: Polycythemia (PCT) iswell-recognized adverse effect of testosterone supplementation. However, widely disparate rates exist in the literature (2-24%) based on varied definitions of PCT and modality of T supplementation. We attempted to determine the rate of PCT in patients in our intramuscular testosterone (IMT) program.METHODS: Symptomatic men with two low total T (TT) levels (<350 ng/dl), using IMT for at least 6 months comprised the study cohort. Men used 200mg IM every 2 weeks and had peak (day 1-2) and trough T (day 13-14) levels checked after two cycles, and every 6 months. PCT was defined as hematocrit (HCT) !52%. Patients were excluded from IMT if they had baseline HCT >48%. A multivariate model was constructed to define predictors of PCT development. Factors assessed included: patient age, mean BMI, cigarette smoking history, baseline HCT, mean per patient peak TT level, mean per patient trou...

Vitamin D and PTH: data from a cross-sectional study in an equatorial population

“…Another hypothesis would be the influence of testosterone levels. It has been suggested that testosterone levels could be associated with higher 25(OH)D levels (26,27,28,29). In fact, Araujo et al also described vitamin D levels higher in males than in females, also suggesting this hormonal influence (30).…”

Evaluation of Parathyroid Hormone and Vitamin D Levels among Surgery Outpatient Clinic Attendants in Shifa Medical Complex: A Cross-sectional Study

“…Testosterone levels may serve as an additional potential explanation for the observed impact. There is a suggested link between testosterone and higher levels of 25(OH)D, as proposed by studies [26][27][28][29] . Araujo et al discovered a correlation between gender and vitamin D levels, with males exhibiting higher levels compared to women.…”