Mp65-08 Heat-Targeted Drug Delivery Using the Combat BRS Device for Treating Bladder Cancer

Brousell, Steven; Longo, Thomas A.; Fantony, Joseph J.; Etienne, Wiguins; Dewhirst, Mark W.; Maccarini, Paolo F.; Spasojević, Ivan; Inman, Brant A.

doi:10.1016/j.juro.2017.02.2002

Cited by 3 publications

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“…In a recent conference abstract, the results of the Combat BRS device for C-HT in pigs were described. In this in-vivo study, C-HT was able to heat the bladder lumen to a temperature of 42.9 ± 0.14 C and generated a transmural gradient of 1.5 C across the detrusor, resulting in full thickness bladder heating of >41 C [27]. However, no comparison with RF-HT was made, and no information on the inflow temperature of the C-HT was given.…”

Section: Discussionmentioning

confidence: 98%

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Inducing intravesical hyperthermia of the ex-vivo porcine bladder wall: radiofrequency-induction versus recirculation using a custom-made device

Valenberg

Witjes

Aklan

et al. 2018

International Journal of Hyperthermia

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Introduction: Several techniques can be used to treat intravesical chemohyperthermia (ChHT). We compared radiofrequency-induced hyperthermia (RF-HT) with conductive hyperthermia (C-HT) for their ability to induce bladder wall temperatures of >40.5 C, the target temperature for ChHT. Materials and Methods: Fresh porcine bladders (n ¼ 12) were placed in a temperature-controlled saline bath to simulate body temperature and circulation. HT was induced with RF-HT (43 C) or C-HT (inflow temperature 44 and 46 C) using a custom-made device. In two additional bladders, we varied intravesical solution and volume. Temperatures were recorded with a three-way catheter containing three mucosal and two urethral thermocouples (TCs) and a 915 MHz RF antenna, and with external TCs in the bladder wall at three different levels and three different locations. Results: Target temperature (40.5 C) was reached in the submucosa at all locations by both techniques. In the detrusor, target temperature was reached by RF-HT at the bladder neck and side wall. C-HT 46 reached significantly higher submucosal temperatures at the side wall. The bladder dome seemed best heated by C-HT, although a high inflow temperature (46 vs. 44 C) was required (ns). Intravesical saline resulted in higher temperatures than sterile water for RF-HT. A volume of 100 mL resulted in higher bladder dome temperatures for RF-HT, and higher bladder neck with lower dome temperatures for C-HT. Conclusion: Our results indicate a slightly superior heating capacity for RF-HT compared to C-HT, whereas for the bladder dome, the reverse seems true. Comparative studies are warranted to evaluate whether HT efficacy differs between both techniques, with emphasis on tumor location.

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Section: Discussionmentioning

confidence: 98%

“…In two other studies, the bladder tissue temperatures associated with the heating techniques used in this study were examined [26,27]. In a recent conference abstract, the results of the Combat BRS device for C-HT in pigs were described.…”

Section: Discussionmentioning

confidence: 99%

Inducing intravesical hyperthermia of the ex-vivo porcine bladder wall: radiofrequency-induction versus recirculation using a custom-made device

Valenberg

Witjes

Aklan

et al. 2018

International Journal of Hyperthermia

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“…In a swine model, Thermodox is able to achieve doxorubicin levels far exceeding free doxorubicin while minimizing toxicity in other organs. 68…”

Section: Safetymentioning

confidence: 99%

Heated Intravesical Chemotherapy

Tan

Longo

Inman

2020

Urologic Clinics of North America

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Non-muscle invasive bladder cancer (NMIBC) can be a challenging disease to manage. In recent years, hyperthermia therapy in conjunction with intravesical therapy has been gaining traction as a treatment option. Hyperthermic intravesical chemotherapy is an alternative method of managing NMIBC, especially if BCG might not be available. Trials of intravesical chemotherapy with heat are few and there has been considerable heterogeneity between studies. However, multiple new trials have accrued and high-quality data is on its way. In this review, we discuss the role of combined intravesical hyperthermia and chemotherapy as a novel approach for the treatment of bladder cancer.

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Development of clinically effective formulations for anticancer applications: why it is so difficult?

Needham

2020

Biomaterials for Cancer Therapeutics

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Mp65-08 Heat-Targeted Drug Delivery Using the Combat BRS Device for Treating Bladder Cancer

Cited by 3 publications

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Inducing intravesical hyperthermia of the ex-vivo porcine bladder wall: radiofrequency-induction versus recirculation using a custom-made device

Inducing intravesical hyperthermia of the ex-vivo porcine bladder wall: radiofrequency-induction versus recirculation using a custom-made device

Heated Intravesical Chemotherapy

Development of clinically effective formulations for anticancer applications: why it is so difficult?

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