Mp7-14 Expression of Steroid Hormone Receptors and Its Prognostic Significance in Urothelial Carcinoma of the Upper Urinary Tract (Ucuut)

Steroid Hormone Receptor Signals as Prognosticators for Urothelial Tumor

“…Of note, in a study using a quantitative polymerase chain reaction (PCR) method, ERα gene was found to be positive in all the 10 tumors examined, which was even stronger (2.77-fold) than in matched normal tissues [ 50 ]. Our immunohistochemical analyses showed higher positive rates in bladder (27% [ 40 ]) and UUT (18% [ 46 ]) tumors, compared with those in other studies described above. In contrast to the findings in PCR analysis [ 50 ], elevated levels of ER α protein expression were detected in nonneoplastic urothelium, compared with urothelial cancer [ 40 , 46 , 53 ].…”

“…Our immunohistochemical analyses showed higher positive rates in bladder (27% [ 40 ]) and UUT (18% [ 46 ]) tumors, compared with those in other studies described above. In contrast to the findings in PCR analysis [ 50 ], elevated levels of ER α protein expression were detected in nonneoplastic urothelium, compared with urothelial cancer [ 40 , 46 , 53 ]. At least two of the immunohistochemical studies also demonstrated that ER α expression was downregulated in higher grade or stage tumors [ 40 , 53 ].…”

“…ER β protein expression was reported to be positive in 22–76% of urothelial tumors, which was significantly lower than the positive rates in nonneoplastic urothelial tissues, in some of the studies [ 30 , 40 , 41 , 46 , 52 , 55 , 56 ] ( Table 1 ). More recently, Tan et al [ 54 ] demonstrated that all the 410 bladder tumors examined were immunoreactive for ER β .…”

“…Immunohistochemical studies have demonstrated that the positive rates of AR expression in bladder or upper urinary tract (UUT) urothelial tumors range from 13% to 55%, which is significantly lower than that in nonneoplastic urothelial tissues [ 25 , 30 , 36 – 46 ] ( Table 1 ). However, two studies showed no AR expression in normal urothelium [ 30 , 43 ].…”

“…Our immunohistochemical studies in bladder [ 62 ] and UUT [ 46 ] tumors showed that most of nonneoplastic urothelial tissues expressed the GR, which was downregulated in urothelial neoplasms ( Table 1 ). GR expression was also significantly reduced in high-grade or muscle-invasive bladder tumors, compared with low-grade or non-muscle-invasive tumors [ 62 ].…”