Mp74-18 the Effect of Thymoquinone on the Renal Functions Following Ischemia-Reperfusion Injury

Hammad, Fayez T.; Lubbad, Loay

doi:10.1016/j.juro.2017.02.2186

Cited by 16 publications

(21 citation statements)

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“…Th erefore, the benefi cial eff ects of the plant extract, which was seen in the present study, might be due to TQ. In supporting to this idea, TQ has also been previously reported to have some benefi cial eff ects on renal functions in animal models such as ischemic renal injury (Hammad and Lubbad 2016), diabetic renal impairment function (Al-Trad et al 2016) and gentamycin-induced renal failure (Samarghandian et al 2015). However, this issue requires further investigations.…”

Section: Discussionmentioning

confidence: 85%

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Mohebbati

Hosseini

Haghshenas

et al. 2017

Endocrine Regulations

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Objective. We investigated the eff ects of hydroalcoholic extract of Nigella sativa (NS) on renal tissue oxidative damage associated with propylthiouracil (PTU)-induced hypothyroidism during neonatal and juvenile growth in rats.Methods. Pregnant rats were divided into fi ve groups designated as: 1) control; 2) propylthiouracil (PTU); 3) PTU-NS100; 4) PTU-NS200, and 5) PTU-NS400. All mothers except the control group received 0.005% PTU in their drinking water during lactation. Besides PTU, mothers in groups 3-5 received 100, 200, and 400 mg/kg of NS extract. Aft er lactation period, the off spring continued to receive the same experimental treatment for the fi rst 8 weeks of their life. Ten male off springs of each group were randomly selected, blood samples collected, and the kidney tissues removed.Results. Th e serum thyroxin concentration in PTU group was lower than control group and improved by extract. PTU increased the renal malondialdehyde (MDA), while reduced the total thiols concentrations and catalase (CAT) and superoxide dismutase (SOD) activity compared to control group. Administration of 200 and 400 mg/kg of NS extract decreased MDA level, while it increased the total thiols and 400 mg/kg increased CAT and SOD activity in renal tissues compared to PTU group. Serum creatinine and blood urea nitrogen (BUN) in PTU group was higher than in comparison with the control group. 400 mg/kg decreased creatinine, but both 200 and 400 mg/kg improved BUN concentration compared to PTU group.Conclusion. Th e results of this study demonstrate that the hydroalcoholic extract of NS has a protective eff ect on the renal tissue oxidative damage associated with PTU-induced hypothyroidism during neonatal and juvenile growth in rats.

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Section: Discussionmentioning

confidence: 85%

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Mohebbati

Hosseini

Haghshenas

et al. 2017

Endocrine Regulations

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“…Notably, TQ has been reported to possess a wide range of biological activity including antitumor [10,11], anti-inflammation [12,13], anti-oxidation [14], and immunoregulatory effects [15]. Furthermore, the protective effect of TQ on MI/R injury has been demonstrated in numerous organs, including the liver [16], spinal cord [17], brain [18], kidney [19] and testis [20]. Additionally, Gonca and Kurt [21] and Ojha et al [14] have demonstrated that TQ could protect cardiomyocytes from MI/R injury.…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Attenuates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1 Signaling

Feng

Liú

et al. 2018

Cell Physiol Biochem

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Background/Aims: Myocardial ischemia/reperfusion (MI/R) injury is a leading factor responsible for damage in myocardial infarction, resulting in additional injury to cardiac tissues involved in oxidative stress, inflammation, and apoptosis. Thymoquinone (TQ), the main constituent of Nigella sativa L. seeds, has been reported to possess various biological activities. However, few reports regarding myocardial protection are available at present. Therefore, this study was conducted aiming to investigate the protective effect of TQ against MI/R injury and to clarify its potential mechanism. Methods: MI/R injury models of isolated rat hearts and neonatal rat cardiomyocytes were established. The Langendorff isolated perfused heart system, triphenyltetrazolium chloride staining, gene transfection, TransLaser scanning confocal microscopy, and western blotting were employed to evaluate the cardioprotection effect of TQ against MI/R injury. Results: Compared with the MI/R group, TQ treatment could remarkably improve left ventricular function, decrease myocardial infarct size and production of lactate dehydrogenase (LDH), and attenuate mitochondrial oxidative damage by elevating superoxide dismutase (SOD) activity and reducing production of hydrogen peroxide (H₂O₂) and malonaldehyde (MDA). Moreover, the cardioprotective effect of TQ was accompanied by up-regulated expression of SIRT1 and inhibition of p53 acetylation. Additionally, TQ treatment could also enhance mitochondrial function and reduce the number of apoptotic cardiomyocytes. Nonetheless, the cardioprotective effect of TQ could be mitigated by SIRT1 inhibitor sirtinol and SIRT1 siRNA, respectively, which was achieved through inhibition of the SIRT1 signaling pathway. Conclusions: The findings in this study demonstrate that TQ is efficient in attenuating MI/R injury through activation of the SIRT1 signaling pathway, which can thus reduce mitochondrial oxidative stress damage and cardiomyocyte apoptosis.

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“…1963 was the year thymoquinone was first extracted as the main active ingredient of NS (14) and it was described as a potent superoxide scavenger and free radical (15)(16)(17). However, NS also has an antioxidative effect on the spinal cord, heart and renal tissue IRI (18)(19)(20).…”

Section: öZetmentioning

confidence: 99%

Assessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Rats

2018

GMJ

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Objective: Ischemia-reperfusion injury is a chain of events put in place by tissue ischemia. Reperfusion following the damage of cell causes an active inflammatory response. In our research we tried to evaluate the protective effect of Levosimendan and Nigella Sativa on myocardial ischemia-reperfusion injury in rats. Methods: We included twenty-four Wistar albino rats in our research. The rats were randomly divided into four experimental groups. The coronary arteries of rats in Group C (control group) were not occluded or reperfused. Left anterior descending coronary artery was ligated for 30 min to perform myocardial IR and then reperfused for 2 h in the IR (IR), IR-Levosimendan (24µg/kg) (IRL) and IR-Nigella Sativa (0.2 mL/kg) (IRNS) group.

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Mp74-18 the Effect of Thymoquinone on the Renal Functions Following Ischemia-Reperfusion Injury

Cited by 16 publications

References 0 publications

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Thymoquinone Attenuates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1 Signaling

Assessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Rats

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