mPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels for ocular delivery of multiple drugs with enhanced synergism

Peng, Xingru; Zhang, Tingting; Wu, Yujie; Wang, Xiaoyu; Liu, Rui; Jin, Xin

doi:10.1016/j.colsurfb.2023.113560

Cited by 6 publications

(2 citation statements)

References 58 publications

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“…Enhance the ocular bioavailability of AS-IV and TMP, which is the enhanced synergism of well-permeable liposome and slow-releasing hydrogel. [56] Travoprost (TRAVO)…”

Section: Ethanol Injection Methodsmentioning

confidence: 99%

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Batur,

Özdemir,

Durgun

et al. 2024

Pharmaceuticals

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Ocular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of the eye. Conventional dosage forms often fail to achieve optimal therapeutic outcomes due to poor bioavailability, short retention time, and off-target effects. In recent years, vesicular drug delivery systems have emerged as promising solutions to address these challenges. Vesicular systems, such as liposome, niosome, ethosome, transfersome, and others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, and spanlastics), offer several advantages for ocular drug delivery. These include improved drug bioavailability, prolonged retention time on the ocular surface, reduced systemic side effects, and protection of drugs from enzymatic degradation and dilution by tears. Moreover, vesicular formulations can be engineered for targeted delivery to specific ocular tissues or cells, enhancing therapeutic efficacy while minimizing off-target effects. They also enable the encapsulation of a wide range of drug molecules, including hydrophilic, hydrophobic, and macromolecular drugs, and the possibility of combination therapy by facilitating the co-delivery of multiple drugs. This review examines vesicular drug delivery systems, their advantages over conventional drug delivery systems, production techniques, and their applications in management of ocular diseases.

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“…Enhance the ocular bioavailability of AS-IV and TMP, which is the enhanced synergism of well-permeable liposome and slow-releasing hydrogel. [56] Travoprost (TRAVO)…”

Section: Ethanol Injection Methodsmentioning

confidence: 99%

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Batur,

Özdemir,

Durgun

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

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“…These factors are favourable because of their ease of control and frequent application in the utilization of controllable materials, particularly in the realm of medical research and development. Jommanee et al utilized a temperature-responsive diblock copolymer synthesized from polyethylene glycol methyl ether (mPEG) and ε-caprolactone (CL), 58 which was subsequently grafted onto chitosan, a pH-responsive biomolecule. 59 This led to the development of chitosan- G -(mPEG45- b -PCL) graft copolymers, which are injectable hydrogels that are responsive to both environmental temperature and pH.…”

Section: Tumour-specific Gelationmentioning

confidence: 99%

Recent research progress on tumour-specific responsive hydrogels

Zhou,

Wang,

Shen

et al. 2024

J. Mater. Chem. B

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Unlocking the Potential of Hybrid Nanocomposite Hydrogels: Design, Mechanical Properties and Biomedical Performances

Li,

Nicolas,

Mura

2024

Adv Funct Materials

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Hybrid nanocomposite hydrogels consist of the homogeneous incorporation of nano‐objects in a hydrogel matrix. The latter, whether made of natural or synthetic materials, possesses a microporous, soft structure that makes it an ideal host for a variety of polymer and lipid‐based nano‐objects as well as metal‐ and silica‐based ones. By carefully choosing the composition and the proportions of the different constituents, hybrid hydrogels can display a wide array of properties, from simple enhancement of mechanical characteristics to specific bioactivity. This review aims to provide an overview of the state of the art in hybrid hydrogels highlighting key aspects that make them a promising choice for a variety of biomedical applications. Strategies for the preparation of hybrid hydrogels are discussed by covering the selection of individual components. The review will also explore the physico‐chemical and rheological characterization of these materials, which is essential for understanding their structure and function, ultimately satisfying specifications for the intended use. Successful examples of biomedical applications will also be presented, and the main challenges to be met will be discussed, with the aim of stimulating the research community to exploit the full potential of these materials.

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mPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels for ocular delivery of multiple drugs with enhanced synergism

Cited by 6 publications

References 58 publications

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Recent research progress on tumour-specific responsive hydrogels

Unlocking the Potential of Hybrid Nanocomposite Hydrogels: Design, Mechanical Properties and Biomedical Performances

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