MPV and PDW as inflammatory indicators in chronic otitis media with effusion

Kepekçi, Ahmet Hamdi

doi:10.4066/biomedicalresearch.29-17-3364

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…19 Discrepancies in MPV value still being found in recent studies. 18 Our study did not show increased MPV value parallel with severity of obesity, although PDW show a positive trend.…”

Section: Discussioncontrasting

confidence: 61%

“…17 A high PDW levels found to be caused by swelling, destruction, immaturity, and high reactivity of platelets. 18 Another study reported that MPV and PDW concentrations were significantly higher in the obese group than in the normal weight control group. 19 In obese individuals, although the mechanism underlying the increase was unclear, procoagulant status may have been induced by adipocytokines such as leptin, adiponectin, resistin, and PAI.…”

Section: Discussionmentioning

confidence: 97%

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Blood count to determine chronic inflammation severity in obese adolescents

Wongkar

Lowis

Warouw

et al. 2020

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Background Obesity is a growing public health problem of rapidly increasing prevalence in developing countries. Chronic low-grade inflammation plays a key role in the pathophysiology of obesity. Blood count values and ratios have been used as markers of inflammatory diseases. These parameters may be useful to determine the severity of chronic inflammation in obese children. Objective To determine if red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet distribution width (PDW), and platelet-to-lymphocyte ratio (PLR) can be useful for determining the severity of chronic inflammation in obese children. Methods This observational, analytic study was conducted in obese adolescents aged 14-18 years at senior high schools in Manado, North Sulawesi, from July to September 2018. Students with congenital anomalies, autoimmune diseases, history of asthma, or malignancy were excluded. Pearson’s correlation was used to analyze for potential relationships between obesity and red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet distribution width (PDW), and platelet-to-lymphocyte ratio (PLR). Results There was a negative relationship between obesity and MPV, but it was not statistically significant (r=-0.006; P=0.485). There were positive, but not significant relationships between obesity and RDW (r=0.139; P=0.192), NLR (r=0.155; P=0.166), PDW (r=0.02; P=0.45), and PLR (r=0.146; P=0.181). Conclusion The RDW, NLR, MPV, PDW, and PLR values are not significantly associated with severity of obesity in adolescents.

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“…19 Discrepancies in MPV value still being found in recent studies. 18 Our study did not show increased MPV value parallel with severity of obesity, although PDW show a positive trend.…”

Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 97%

Blood count to determine chronic inflammation severity in obese adolescents

Wongkar

Lowis

Warouw

et al. 2020

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Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches

Mirinezhad,

Aghasizadeh,

Ghazizadeh

et al. 2024

CHDDT

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Background: Premature Ovarian Insufficiency (POI) is associated with infertility. Little is known about the potential circulating biomarkers that could be used to predict POI. We have investigated the possible association between white and red blood cells, platelet indices, and eight established single nucleotide polymorphisms (SNPs) associated with POI risk. Method: 117 women with premature menopause (PM) and 183 healthy women without a history of menopause before age 40 were recruited for this study. The tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra ARMS PCR) and allele-specific oligonucleotides-polymerase chain reaction (ASO-PCR) were carried out for genotyping for eight SNPs reported to be associated with POI. Decision tree analysis was applied to test the diagnostic value of hematological parameters to identify the risk of POI. Results: Women with POI had lower neutrophil (NEUT) and white blood cell (WBC), whereas red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), and mean cell hemoglobin (MCH) were higher. Platelet (PLT) count was also lower in affected women. Our data also indicated that HGB and HCT count were significantly associated with rs16991615 and rs244715. Mean Platelet volume (MPV) and platelet distribution width (PDW) were associated with rs244715, rs1046089, rs4806660, and rs2303369. The rs16991615 was also associated with RBC count, and rs451417 was associated with NEUTs. The decision tree (DT) model reveals that women with the NEUT count at a cut-off value of less than 2.8 and HCT equal to or more than 38.7% could be identified as high-risk cases for POI. Overall, we found the DT approach had a sensitivity = 85%, specificity = 72%, and accuracy = 74%. Conclusion: The genetic variants involved in POI are associated with changes in reproductive hormone levels and with changes in hematological indices.

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MPV and PDW as inflammatory indicators in chronic otitis media with effusion

Cited by 2 publications

References 25 publications

Blood count to determine chronic inflammation severity in obese adolescents

Blood count to determine chronic inflammation severity in obese adolescents

Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches

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