MR‐guided 125I seed implantation treatment for maxillofacial malignant tumor

Abstract

PurposeThis study assessed the therapeutic efficacy of postoperative magnetic resonance (MR)‐guided interstitial 125I seed implantation for treatment of oral and maxillofacial malignant tumors.Methods and MaterialsA total of 127 patients with oral or maxillofacial malignant tumors were included in this study who received interstitial 125I treatment after the surgery resection. Before implantation, all the patients received MR scans to assess the lesion scope, extent, and nature. 125I implantation target regions were based on the pre‐operative imaging. 125I seeds were delivered to target regions via puncture needles under the real‐time guidance of MR. Computed tomography (CT)or MR was performed immediately after implantation and again every 3 months later.ResultsAfter successful 125I implantation, all patients were also examined regularly to detect tumor recurrence, lymphatic, and distant metastases. To date, CT or MR verification showed that 13/127 patients experienced tumor recurrence or lymphatic metastasis or distant metastasis. No seeds migration was observed, no serious treatment‐related complications affected patient quality of life, and no important organ (such as major cervical vessels, spinal cord, etc.) injuries were observed.ConclusionOur results show that MR‐guided 125I implantation is an effective approach to site‐specific treatment for oral and maxillofacial tumor, which could potentially reduce postoperative complications and tumor recurrence rates, increase patient survival, and improve quality of life.

Safety and efficacy of iodine-125 seed strand for intraluminal brachytherapy on ureteral carcinoma

“…Currently, more minimally invasive alternative methods are urgently needed in clinical practice for such patients with ureteral carcinoma who are not suitable for surgical resection. Minimally invasive treatment using interstitial puncture and the implantation of iodine-125 seeds has become a common clinical technique for the treatment of various solid malignancies ( 15 ), such as oral and maxillofacial malignant tumors ( 16 ). However, it remains unclear whether malignant tumors of cavity organs such as ureteral carcinoma can be treated by radioactive seeds brachytherapy, although cavity organs such as esophageal cancer have been treated with low-dose-rate brachytherapy with radioactive stent ( 17 ) and nutrient tube ( 7 ).…”

Feasibility of 125I brachytherapy combined with arterial infusion chemotherapy in patients with advanced pancreatic cancer

“…The 125 I radiation range is small and precise with high local treatment dose, high-dosed radiation increased local tumor control and OS. [8][9][10] A computer 3-dimensional TPS and CT-guided imaging can accurately position particle placement position and help peripheral tumor doses reach the MPD of 100 to 150 Gy and reduce the risk of local recurrence. Dose distribution around the source decreased according to the distance of radioactive sources by the inverse square law.…”

“…While, the radiation dose outside the radioactive sources can decay quickly, with less damage on the surrounding normal tissues and better protection of the normal tissues. [8][9][10] Intraoperative radiotherapy is another type of brachytherapy. However, it is only suitable for patients willing to undergo surgery.…”

Iodine-125 seed implantation in the treatment of malignant tumors

“…However, its clinical application is limited by its high cost, susceptibility to interference from vascular pulsations, and the need for MR-specific surgical instruments. 40 In open-view delivery during surgical procedures, 125 I seeds are delivered via a needle to a designated site. This method is typically used as an adjuvant treatment in patients with positive incision margins or a high expected recurrence rate after surgical resection.…”