MR imaging assessment of myocardial edema with T2 mapping

Montant, Patrick; Sigovan, Monica; Revel, D.; Douek, Philippe

doi:10.1016/j.diii.2014.07.008

Cited by 45 publications

(28 citation statements)

References 28 publications

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“…SNR efficiency ratios of the SE sequence relative to the STEAM approach were calculated and compared with the theoretical values according to equations [1] and [2] taking the individual sequence timing (TR, TM, TE) into account. Relaxation times (T1 ¼ 1030 ms/T2 ¼ 52 ms) were taken from literature (49,50).…”

Section: Discussionmentioning

confidence: 99%

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Spin echo versus stimulated echo diffusion tensor imaging of the in vivo human heart

Deuster

Stoeck

Genet

et al. 2015

Magnetic Resonance in Med

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PurposeTo compare signal‐to‐noise ratio (SNR) efficiency and diffusion tensor metrics of cardiac diffusion tensor mapping using acceleration‐compensated spin‐echo (SE) and stimulated echo acquisition mode (STEAM) imaging.MethodsDiffusion weighted SE and STEAM sequences were implemented on a clinical 1.5 Tesla MR system. The SNR efficiency of SE and STEAM was measured (b = 50–450 s/mm2) in isotropic agar, anisotropic diffusion phantoms and the in vivo human heart. Diffusion tensor analysis was performed on mean diffusivity, fractional anisotropy, helix and transverse angles.ResultsIn the isotropic phantom, the ratio of SNR efficiency for SE versus STEAM, SNRt(SE/STEAM), was 2.84 ± 0.08 for all tested b‐values. In the anisotropic diffusion phantom the ratio decreased from 2.75 ± 0.05 to 2.20 ± 0.13 with increasing b‐value, similar to the in vivo decrease from 2.91 ± 0.43 to 2.30 ± 0.30. Diffusion tensor analysis revealed reduced deviation of helix angles from a linear transmural model and reduced transverse angle standard deviation for SE compared with STEAM. Mean diffusivity and fractional anisotropy were measured to be statistically different (P < 0.001) between SE and STEAM.ConclusionCardiac DTI using motion‐compensated SE yields a 2.3–2.9× increase in SNR efficiency relative to STEAM and improved accuracy of tensor metrics. The SE method hence presents an attractive alternative to STEAM based approaches. Magn Reson Med 76:862–872, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

“…The SNR t (SE/STEAM) ratio is seen to decrease with increasing heart rate but remains greater than 2.3 up to heart rates of 90 min À1 . At a heart rate of 60 min À1 and T 1 /T 2 ¼ 1030/52 ms (49,50), the theoretical SNR gain of SE relative to STEAM is approximately 3.5Â.…”

Section: Methodsmentioning

confidence: 98%

Spin echo versus stimulated echo diffusion tensor imaging of the in vivo human heart

Deuster

Stoeck

Genet

et al. 2015

Magnetic Resonance in Med

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“…Qualitative variables were compared with the χ or Fisher exact test. Quantitative variables were first tested for normality in distribution.…”

Section: Methodsmentioning

confidence: 99%

“…MRI is now a pivotal examination for the assessment of a variety of pathological conditions involving many organs . Although unenhanced MRI can be a diagnostic solving tool in some indications, contrast‐enhanced MRI is often needed to improve lesion detection and characterization and heighten confidence in diagnosis.…”

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confidence: 99%

“…Although unenhanced MRI can be a diagnostic solving tool in some indications, contrast‐enhanced MRI is often needed to improve lesion detection and characterization and heighten confidence in diagnosis. In addition, in some specific areas MRI with intravenous (IV) administration of gadolinium‐based contrast agent (GBCA) remains the standard of reference for MRI …”

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confidence: 99%

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Observational study on the safety profile of gadoterate meglumine in 35,499 patients: The SECURE study

Soyer

Dohan

Patkar

et al. 2016

Magnetic Resonance Imaging

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Purpose: To investigate the safety of gadoterate meglumine and identify the incidence of nephrogenic systemic fibrosis (NSF). Materials and Methods: An international prospective observational study was conducted from November 2008 to June 2013. A total of 35,499 adults and children who were scheduled to undergo contrast-enhanced MRI using gadoterate meglumine were analyzed (female, 53.1%; mean age: 49.5 years; range: 0-98 years). At least 3-month follow-up was planned for patients with an estimated creatinine clearance or glomerular filtration rate <60 mL/min (/1.73 m2) to detect any suspicion or occurrence of NSF. Adverse events (AEs) were prospectively recorded. Demographic data, risk factors, indications for MRI examinations, characteristics of gadoterate meglumine administration, and efficacy were documented. Results: MRI examinations were mainly for central nervous system (61%). The most frequent risk factor was renal insufficiency (14.7%). Seventy AEs were observed in 44 patients (0.12%). Among the 70 AEs, 38 in 32 patients (0.09% of all patients) were considered related to gadoterate meglumine and classified as adverse drug reaction (ADR).The most frequent ADRs were urticaria (9 patients, 0.03%), nausea (7 patients, 0.02%), and vomiting (4 patients, 0.01%). Within the pediatric population (1,629 patients), only one AE (vomiting) was observed. Nine adult patients (0.03%) experienced serious AEs. Moderate to severe renal insufficiency at inclusion was reported in 514 patients (1.5%). Among them, 476 (92.6%) were followed-up. No patients were suspected of having NSF and no cases of NSF were observed. Conclusion: Our study confirms the excellent safety profile of gadoterate meglumine in routine practice. Level of Evidence: 1

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Meta‐analysis of cardiac magnetic resonance in prognosticating left ventricular function in peripartum cardiomyopathy

Prameswari,

Kamarullah,

Pranata

et al. 2024

ESC Heart Failure

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AimsPeripartum cardiomyopathy (PPCM) may result in a number of detrimental adverse cardiovascular events, notably persistent left ventricular ejection fraction (LVEF) reduction or even mortality. Imaging parameters on cardiac magnetic resonance (CMR) and their prognostic implications have rarely been perused in PPCM. We aimed to describe CMR's prognostic value in predicting poor left ventricular (LV) function recovery using late gadolinium enhancement (LGE) and T2‐weighted or T2 mapping.Methods and resultsPubMed, Europe PMC, and ScienceDirect were screened for studies on late gadolinium enhancement (LGE) and myocardial oedema using CMR and PPCM. The outcome of interest was poor LV function recovery, with a follow‐up period of at least 6 months. Comparisons between groups with the presence of LGE, myocardial oedema, and recovered against non‐recovered patients were pooled. A random‐effects model was employed to calculate the effect size. All pooled results were expressed as risk ratios (RRs) and 95% confidence intervals (CI). The area under the curve (AUC) was generated to test overall prognostic accuracy. Six cohort studies with 162 patients were included. The mean age of participants in this study was 30.6 years, and the majority of patients were diagnosed with PPCM after delivery. LGE was associated with a higher risk of poor LV function recovery, particularly when conducted at a later stage of disease (≥2.8 months) [RR = 2.83 (95% CI = 1.25–6.40); P = 0.001]. On the contrary, CMR conducted early (<2.8 months) exhibited a greater predictive value for myocardial oedema perceived by T2 mapping [RR = 3.44 (95% CI = 1.04–11.34); P = 0.043]. Diagnostic‐test accuracy meta‐analysis revealed that LGE had a sensitivity of 73% (95% CI, 56–85%), specificity of 79% (95% CI, 45–95%), and AUC of 0.78 (95% CI, 0.75–0.82) in predicting poor LV recovery when performed in the later phase, whereas significant myocardial oedema in those with non‐recovered LV function had a sensitivity of 12% (95% CI, 2–52%), specificity of 68% (95% CI, 39–88%), and AUC of 0.40 (95% CI, 0.36–0.44) while undertaken in the latter phase. Our findings support the notion that inflammation plays a significant role in PPCM and that alterations to tissue composition occur in a time‐dependent manner.ConclusionsContrast‐enhanced CMR can be utilized as an adjunct examination in post‐partum PPCM patients to stratify the risk of poor LV function recovery while conducted at a suitable point in time.

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MR imaging assessment of myocardial edema with T2 mapping

Cited by 45 publications

References 28 publications

Spin echo versus stimulated echo diffusion tensor imaging of the in vivo human heart

Spin echo versus stimulated echo diffusion tensor imaging of the in vivo human heart

Observational study on the safety profile of gadoterate meglumine in 35,499 patients: The SECURE study

Meta‐analysis of cardiac magnetic resonance in prognosticating left ventricular function in peripartum cardiomyopathy

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