MR imaging findings in children with pseudotumor cerebri and comparison with healthy controls

Görkem, Süreyya Burcu; Doğanay, Selim; Canpolat, Mehmet; Koc, Gonca; Dogan, Mehmet Sait; Per, Hüseyin; Çoşkun, Abdulhakim

doi:10.1007/s00381-014-2579-0

Cited by 56 publications

(38 citation statements)

References 24 publications

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“…These findings include the following: posterior globe flattening, intraocular protrusion of the optic nerve, horizontal nerve sheath tortuosity, optic nerve sheath distension, and a decrease in the size of the pituitary gland. 26 In this study, the brain MR images of pseudotumor cerebri patients were normal.…”

Section: Discussionmentioning

confidence: 77%

Neurological Manifestations in Familial Mediterranean Fever: Results of 22 Children from a Reference Center in Kayseri, an Urban Area in Central Anatolia, Turkey

et al. 2016

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Familial Mediterranean fever (FMF) is an inherited inflammatory disorder characterized by attacks of fever with polyserositis. The purpose of this study was to evaluate pediatric patients with FMF who had central nervous system (CNS) findings. Our medical records database for 2003 to 2014 was screened retrospectively. In total, 104 patients with FMF were identified, 22 of whom had undergone neurological examination for CNS symptoms. Neurological findings included headache in 16 patients (72.7%), epilepsy in 6 patients (27.3%), pseudotumor cerebri in 2 patients (9.1%), tremor in 2 patients (9.1%), and multiple sclerosis in 1 patient (4.5%). The most common gene mutation was homozygous M694V (40.9%). Patients with FMF can present with various CNS manifestations. Further studies that include large populations are needed to elucidate the neurological manifestations of FMF.

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Section: Discussionmentioning

confidence: 77%

Neurological Manifestations in Familial Mediterranean Fever: Results of 22 Children from a Reference Center in Kayseri, an Urban Area in Central Anatolia, Turkey

et al. 2016

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“…Skull base crowding and prominence of arachnoid granulations were not significant. Görkem et al 26 reported similar findings in their retrospective review of 25 pediatric pseudotumor cerebri patients, reporting moderate to high sensitivities and specificities for each of these parameters. Hartmann et al 27 also found similar results and noted that compared with adolescents, prepubertal children were less likely to exhibit flattening of the globe and more likely to show perioptic arachnoid expansion, optic nerve tortuosity, empty sella, and transverse sinus stenosis.…”

Section: Diagnostic Testingmentioning

confidence: 56%

Pediatric Idiopathic Intracranial Hypertension

Gaier

Heidary

2019

Semin Neurol

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The presentation of idiopathic intracranial hypertension (IIH) in pediatric populations has several important distinctions from that in adults, especially among prepubertal patients, in which there is no apparent association with gender or obesity. Pediatric patients are more likely to be asymptomatic or present with atypical symptoms than their adult counterparts, posing a diagnostic challenge in some cases. It is important to be aware of the ways in which diagnostic criteria for IIH are modified from that of adults. Ideal treatment practices and the natural history of pediatric IIH remain unclear. Acetazolamide is the mainstay of medical treatment, but some patients with significant visual loss may require surgical intervention. Multicenter studies to accrue a large number of cases and future prospective studies will help to better define pediatric IIH and to formulate consensus guidelines for treatment and management of these patients.

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“…20 MRI findings suggestive of IH in children include: posterior globe flattening, intraocular protrusion of the optic nerve, horizontal tortuosity of the optic nerve, optic nerve sheath enlargement, and decreased size of the pituitary gland. 21,22 Lumbar puncture is indicated to measure the CSF opening pressure and to exclude meningitis. 1,23 Diagnosis of IH is made according to the modified Dandy criteria.…”

Section: Results a Total Of 53 Children With Ih Werementioning

confidence: 99%

Pediatric intracranial hypertension

Bashiri

Abdulsalam

Hassan

et al. 2019

NSJ

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Objectives: To review the experience of 2 tertiary centers in Saudi Arabia with intracranial hypertension)IH(in the pediatric population. Methods: We retrospectively reviewed and analyzed pediatric patients diagnosed with IH from June 2002 to May 2017 in 2 institutes. Original Articles Results: We identified 53 patients)30 females and 23 males(with a mean age of 7 years at the time of presentation. Among them, 41 patients were younger than 12 years, and 12 were older. Obese and overweight patients constituted 27.00%)n = 14(of all cases, 8)66.7%(of whom were older than 12 years. The most common presenting feature was papilledema followed by headache. Vitamin D deficiency, which constituted the most common associated condition, was identified in 12)22.6%(patients. Acetazolamide was the treatment option in 98.11% of patients, and only 5.7% underwent surgical interventions. The length of follow-up ranged from 6 months to 8 years. Conclusion: Intracranial hypertension is rare in children and commonly seen in overweight females older than 12 years similar to adults. Patients younger than 12 years tend to develop secondary IH. More studies are needed to characterize the clinical presentation and guide the management plan.

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MR imaging findings in children with pseudotumor cerebri and comparison with healthy controls

Abstract: According to our study, posterior globe flattening, intraocular protrusion of the optic nerve, horizontal nerve sheath tortuosity, optic nerve sheath distension, and decreased pituitary gland size are reliable neuroradiological diagnostic markers for pediatric pseudotumor cerebri.

Cited by 56 publications

References 24 publications

Neurological Manifestations in Familial Mediterranean Fever: Results of 22 Children from a Reference Center in Kayseri, an Urban Area in Central Anatolia, Turkey

Neurological Manifestations in Familial Mediterranean Fever: Results of 22 Children from a Reference Center in Kayseri, an Urban Area in Central Anatolia, Turkey

Pediatric Idiopathic Intracranial Hypertension

Pediatric intracranial hypertension

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