Purpose: PI-RADS v2 dictates that dynamic contrast enhanced (DCE) imaging be used to further classify peripheral zone (PZ) cases that receive a diffusion weighted imaging equivocal score of 3 (DWI3), a positive DCE resulting in an increase in overall assessment score to a 4, indicative of clinically significant prostate cancer (csPCa). However, the accuracy of DCE in predicting csPCa in DWI3 PZ cases is unknown. This study sought to determine the frequency with which DCE changes the PI-RADS v2 DWI3 assessment category, and to determine the overall accuracy of DCE-MRI in equivocal PZ DWI3 lesions. Materials and Methods: This is a retrospective study of patients with pathologically-proven PCa who underwent prostate mpMRI at 3T and subsequent radical prostatectomy. PI-RADS v2