MR imaging of articular cartilage using driven equilibrium

Hargreaves, Brian A.; Gold, Garry E.; Lang, Philipp; Conolly, Steven M.; Pauly, John M.; Bergman, Gabrielle; Vandevenne, Jan; Nishimura, Dwight G.

doi:10.1002/(sici)1522-2594(199910)42:4<695::aid-mrm11>3.0.co;2-z

Cited by 91 publications

(67 citation statements)

References 33 publications

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“…These techniques produce contrast by enhancing the signal from synovial fluid rather than attenuation of cartilage signal as in T2-weighted sequences. DEFT and FEMR show much greater cartilage to fluid contrast than spoiled gradientrecalled (SPGR), proton-density spin-echo (PD-SE) or T2-weighted fast-spin-echo (FSE) sequences [56].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

Doria

2010

Haemophilia

102

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Summary. In spite of the fact that the diagnosis of haemophilia is essentially clinical and laboratorybased, imaging has become an important tool for the evaluation of complications, diagnostic confirmation and/or complementation and therapeutic follow-up in haemophilic arthropathy. Radiography remains the workforce horse in the diagnosis and follow-up of haemophilic arthropathy. The radiographical findings in arthropathy follow an expected sequence of events and are overall similar in different joints. Magnetic resonance imaging (MRI) has advantages over radiography based on its capability of visualizing soft tissue and cartilage changes in haemophilic joints. The recent development and standardization of MRI scoring systems for measuring soft tissue and cartilage abnormalities may enable the comparison of pathological joint findings in clinical trials conducted at different institutions across the world. The implementation of high-frequency transducers and colour/power Doppler capabilities has provided new insights for clinical applications of ultrasonography (US) in haemophilic arthropathy. In spite of the imaging modality's technical challenges such as operator-dependency, US has advantages over MRI. One of these advantages is its ability of differentiating synovium hypertrophy and hemosiderin deposition, which is not possible with MRI given the presence of susceptibility artefacts from extracellular hemosiderin on gradient-echo MR images. In addition to the aforementioned conventional imaging modalities, novel imaging techniques (blood oxygen level dependent, ultrasmall superparamagnetic ironoxide contrast-enhanced, and T1 and T2 mapping MRI, ultrasound biomicroscopy, microbubble contrast-enhanced US and positron emission tomography, among others) hold promise for early assessment of haemophilic arthropathy in the future upon completion of their clinical validation.

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

Doria

2010

Haemophilia

102

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“…Although several MR pulse sequences have been proposed (21)(22)(23)(24)(25)(26)(27)(28)(29)(30), it has not yet been shown which sequence is the best for cartilage pathology. It is essential to evaluate the cartilage abnormalities with regard to both intrinsic signal intensity changes and surface contour changes.…”

Section: Discussionmentioning

confidence: 99%

Imaging of the articular cartilage in osteoarthritis of the knee joint: 3D spatial‐spectral spoiled gradient‐echo vs. fat‐suppressed 3D spoiled gradient–echo MR imaging

Yoshioka

Alley

Steines

et al. 2003

Magnetic Resonance Imaging

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Purpose:To compare three-dimensional (3D) spatial-spectral (SS) spoiled gradient-recalled acquisition in the steady state (SPGR) imaging with fat-suppressed 3D SPGR sequences in MR imaging of articular cartilage of the knee joint in patients with osteoarthritis. Materials and Methods:MR images of six patients with osteoarthritis of the knee were prospectively examined with a 1.5T MR scanner. For quantitative analyses, the signalto-noise ratios, contrast-to-noise ratios, and contrast of cartilage and adjacent structures including meniscus, synovial fluid, muscle, fat tissue, and bone marrow were measured. Results:In patients with osteoarthritis, 3DSS-SPGR images demonstrated higher spatial resolution and higher mean signal-to-noise (S/N) ratios (cartilage, 24.9; synovial fluid, 12.3; muscle, 20.7; meniscus, 21.6), with shorter acquisition times (7 minutes 20 seconds), when compared to fat-suppressed 3D SPGR images (cartilage, 22.3; synovial fluid, 10.8; muscle, 16.7; meniscus, 13.4).Conclusion: 3DSS-SPGR imaging is a promising method for evaluating cartilage pathology in patients with osteoarthritis of the knee and has the potential to replace fatsuppressed 3D SPGR imaging.

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“…Kıkırdağın sinyali korunurken sinovyal sıvı sinyalinin güçlenmesiyle sıvı ve kıkırdak arasındaki kontrast artırılır. DEFT görüntülemedeki kısa TE yüzünden sıvının sinyal intensitesi SPGR'den kı-kırdağın sinyal intensitesi de T2A FSE sekanstan daha yüksektir [48]. Bu tekniğin kıkırdak patolojilerini saptamada tanısal performansı 2D FSE ve SPGR tekniği ile benzerdir [49].…”

Section: Kıkırdak Görüntülemede Yeni Geliştirilen Tekniklerunclassified

Diz Eklemi: Kikirdak

Sabir¹,

Tanriverdi²

2017

Trd Sem

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Kıkırdak Yapısı ve FonksiyonuEklem kıkırdağı net ağırlığının %4'ü kondrositlerden, geri kalan büyük kısmı ekstraselü-ler matriksten oluşur. Ekstraselüler mesafenin %65-85'ini su, çok az bir kısmını proteoglikan ve tip II kollajen oluşturur [1,2]. Yüksek sı-kıştırma kuvvetine dayanmayı sağlayan proteoglikan kıkırdak net ağırlığının %3-10'unu oluştururken, gerilme kuvvetinden sorumlu kollajen %15-20'sini yapar [1]. Eklem kıkırda-ğının lenfatiklerden, kan damarı ve sinirlerden yoksun olması iyileşme ve onarım potansiyelini kısıtlar [2]. Eklem kıkırdağının makromoleküler matris yapısının korunması eklem sağ-lığı için hayatidir. Tip II kollajenin kompleks üç boyutlu oryantasyonu doku anizotropisinden sorumludur [3]. Kıkırdağın eklem yüzeyi lamina splendis ile korunur; yoğun kollajen demetlerinin yüzeyindeki lubrisin adı verilen proteoglikan ve sinovyal sıvı kayganlık sağlar [4]. Kıkırdağın yüzeyel zonu kollajen lifleri ve eklem yüzeyine paralel elonge kondrositlerden; orta zon yuvarlak kontrositler ile rastgele konumlanmış kollajen fiberlerinden; derin zon ise kemik yüzeye dik olarak yerleşmiş elonge kondrositlerden ve kalın kollajen demetlerinden oluşur. Derin zonda radyal uzanan kollajen fibrilleri subkondral kemiğe bağlanmak için kalsifiye zona uzanır [2].Ayak bileği kıkırdak kalınlığı ortalama 1,1 mm iken; patella kıkırdağı farklı olarak 5 mm ve üzeri olabilir [5,6]. Farklı eklemlerdeki farklı kıkırdak yapıları gelişen farklı tipte kı-kırdak lezyonlarını da açıklar; örneğin idyopatik osteoartrit diz eklemi kıkırdağında daha sık iken osteokondral lezyonlar daha sık ayak bileğinde görülür [7]. Kıkırdak Görüntüleme EndikasyonlarıOsteoartrit, kronik ve akut osteokondral zedelenme, kondromalazi patella, femur kondilinin spontan osteonekrozu (SONK veya Ahlbaeck's hastalığı), enflamatuar artropatiler, invaziv kıkırdak onarımı ve konzervatif terapiler

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MR imaging of articular cartilage using driven equilibrium

Cited by 91 publications

References 33 publications

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

State‐of‐the‐art imaging techniques for the evaluation of haemophilic arthropathy: present and future

Imaging of the articular cartilage in osteoarthritis of the knee joint: 3D spatial‐spectral spoiled gradient‐echo vs. fat‐suppressed 3D spoiled gradient–echo MR imaging

Diz Eklemi: Kikirdak

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