MR imaging of glioblastoma in children: usefulness of diffusion/perfusion-weighted MRI and MR spectroscopy

Chang, Yun Woo; Yoon, Hye-Kyung; Shin, Hyeonjoon; Roh, Hong Gee; Cho, Jae Min

doi:10.1007/s00247-003-0968-8

Cited by 67 publications

(41 citation statements)

References 26 publications

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“…It was found to be more accurate than diffusion metrics and spectroscopic parameters for classifying adult gliomas [12] . Few studies have evaluated contrast-enhanced DSC perfusion MRI for grading of pediatric brain tumors, and all of them have found rCBV to be a useful parameter for discriminating high-grade neoplasms from low grade ones [7,17,18] . Arterial spin labeling perfusion techniques have also been used to grade pediatric brain tumors [5] .…”

Section: Discussionmentioning

confidence: 99%

Role of Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Pediatric Brain Tumors on 3T

Gupta¹,

Saini²,

Sahoo³

et al. 2017

Pediatr Neurosurg

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Background/Aims: Perfusion magnetic resonance imaging (MRI) is useful for preoperative assessment of brain tumors. Dynamic susceptibility contrast perfusion MRI is commonly used for evaluation of brain tumors. Dynamic contrast-enhanced (DCE) MRI is an alternative method that has mainly been used in adult brain tumors. In this preliminary study, we report our initial experience with the DCE perfusion MRI in pediatric brain tumors. Methods: Sixty-four newly diagnosed pediatric brain tumor patients underwent DCE perfusion MRI on a 3-T scanner. Hemodynamic and kinetic parametric maps were generated and the regions with the highest values were measured on each map. Statistical differences were sought to differentiate between low-grade tumors, high-grade tumors, and medulloblastomas. The perfusion metrics of common posterior fossa tumors were also compared. Results: Relative corrected cerebral blood volume (rCBV) and fractional plasma volume measures differed significantly between high- and low-grade tumors (p < 0.05). High-grade tumors could be differentiated from low-grade tumors, with an rCBV cutoff value of 2.41 and 88.6% sensitivity and 65% specificity. There was no significant difference in K^trans, K_ep, V_e, or λ^tr between these 2 groups of tumors. rCBV, relative quantification of the cerebral blood flow, and permeability indices were found to be significantly different in various posterior fossa tumors, i.e., pilocytic astrocytoma, ependymoma, and medulloblastoma (p < 0.05). Conclusion: DCE-derived perfusion metrics are useful in differentiating high-grade tumors from low-grade ones and discriminating among various posterior fossa tumors in the pediatric age group.

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Section: Discussionmentioning

confidence: 99%

Role of Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Pediatric Brain Tumors on 3T

Gupta¹,

Saini²,

Sahoo³

et al. 2017

Pediatr Neurosurg

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“…Primitive neuroectodermal tumors, atypical teratoid rhabdoid tumors, and glioblastomas may present with imaging characteristics similar to those of PXAs. 3,4 The purpose of this retrospective study was to seek MR imaging and diffusion MR imaging features that may be helpful in correctly diagnosing pediatric PXA preoperatively.…”

mentioning

confidence: 99%

Pleomorphic Xanthoastrocytoma of Childhood: MR Imaging and Diffusion MR Imaging Features

Moore¹,

Mathis

Gargan

et al. 2014

AJNR Am J Neuroradiol

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“…4,5 However, the GBM with restricted water diffusion, that is, hyperintense on trace images and hypointense on ADC maps, has also been reported. [8][9][10][11][12] Therefore, discrimination of lymphoma from some GBMs may be difficult.…”

mentioning

confidence: 99%

Primary Cerebral Lymphoma and Glioblastoma Multiforme: Differences in Diffusion Characteristics Evaluated with Diffusion Tensor Imaging

Toh¹,

Castillo²,

Wong³

et al. 2007

AJNR Am J Neuroradiol

213

161

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MR imaging of glioblastoma in children: usefulness of diffusion/perfusion-weighted MRI and MR spectroscopy

Abstract: Diffusion/perfusion MR imaging and MR spectroscopy are very helpful in diagnosing glioblastoma, determining the biopsy site, and evaluating tumor recurrence.

Cited by 67 publications

References 26 publications

Role of Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Pediatric Brain Tumors on 3T

Role of Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Pediatric Brain Tumors on 3T

Pleomorphic Xanthoastrocytoma of Childhood: MR Imaging and Diffusion MR Imaging Features

Primary Cerebral Lymphoma and Glioblastoma Multiforme: Differences in Diffusion Characteristics Evaluated with Diffusion Tensor Imaging

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