MR imaging of osteochondral grafts and autologous chondrocyte implantation

Trattnig, Siegfried; Millington, Steven; Szomolányi, Pavol; Marlovits, Stefan

doi:10.1007/s00330-006-0333-z

Cited by 169 publications

(119 citation statements)

References 73 publications

(138 reference statements)

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“…14 This point-scoring system was designed to systematically record the constitution of the area of cartilage repair and surrounding tissues, and has been shown to be reliable and reproducible and can be applied to different surgical cartilage repair techniques. 4,15 The maximum score achievable in the evaluation of nine variables is 100. MOCART scoring was performed at the baseline and at the 1-year follow-up MR scan to confirm the morphological condition of the cartilage repair tissue over time.…”

Section: Resultsmentioning

confidence: 99%

“…4,5 To obtain a better insight into the ultrastructural composition of the cartilage repair tissue, biochemical MRI techniques have shown promising results in recent studies. [6][7][8] For the assessment of the constitution and organization of healthy articular cartilage as well as cartilage repair tissue, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and the mapping of transverse relaxation times (T2-mapping) are most often utilized.…”

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confidence: 99%

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Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

Welsch

Mamisch

Marlovits

et al. 2009

Journal Orthopaedic Research

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The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of cartilage repair tissue maturation after matrix-associated autologous chondrocyte transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 AE 12.1 months after cartilage transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 AE 12.0 months after surgery), a longitudinal 1-year followup MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steadystate sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the cartilage repair area and in control cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy cartilage and cartilage repair tissue (p < 0.05). Using zonal T2 evaluation, healthy cartilage showed a significant increase from the deep to superficial cartilage layers (p < 0.05). Cartilage repair tissue after MACT showed no significant zonal increase from deep to superficial cartilage areas during baseline MRI (p > 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of cartilage repair tissue. ß

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

Welsch

Mamisch

Marlovits

et al. 2009

Journal Orthopaedic Research

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“…It is an excellent research instrument for articular tissue and there is considerable potential for expansion of the role of MRI in clinical practice. [13][14][15][16] Extensive work by Eckstein et al [17][18][19][20] has shown spoiled 3D gradient echo (FLASH) sequences with water excitation to be particularly useful. However, most articular cartilage imaging work has concentrated on the knee joint, [21][22][23][24][25][26] which displays the thickest articular cartilage layers in the human body.…”

Section: Introductionmentioning

confidence: 99%

Quantitative and topographical evaluation of ankle articular cartilage using high resolution MRI

Millington

Tang

et al. 2006

Journal Orthopaedic Research

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The objectives of this study were to quantitatively evaluate the articular cartilage layers of the ankle and describe the cartilage topographical distribution across the joint surfaces using high resolution MRI and image segmentation. An anisotropic diffusion noise reduction algorithm and a directional gradient vector flow (dGVF) snake segmentation algorithm were applied to cartilage sensitive MR images. Eight cadaveric ankles were studied. Six repeated data sets were acquired in five of the ankles. Quantitative parameters were calculated for each cartilage layer; coefficients of variation (CV) were calculated from the six repeated data sets; and 3D thickness distribution maps were generated. The noise reduction algorithm produced marked image enhancement. Mean cartilage thickness ranged from 0.91 AE 0.08 mm in the fibula to 1.34 AE 0.14 mm in the talus. Mean cartilage volume was 3.32 AE 0.55 ml, 1.72 AE 0.25 ml, and 0.35 AE 0.06 ml for the talus, tibia, and fibula, respectively. Mean CV ranged 2.82%-5.04% for quantitative parameters in the talus and tibia. The reported noise reduction and segmentation technique allow precise extraction of ankle cartilage and 3D reconstructions show that the thickest cartilage occurs over the talar shoulders, where osteochondritits dissecans (OCD) lesions commonly occur. ß

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“…Early osteoarthritis (OA), as well as cartilage repair, demand advanced MR sequences. Whereas some imaging techniques attempt to either visualize qualitatively the morphology of cartilage and cartilage repair tissue (4,5), others seek to obtain quantitative information to grade the altered cartilage in comparison to healthy hyaline cartilage (6 -8).…”

mentioning

confidence: 99%

Rapid estimation of cartilage T2 based on double echo at steady state (DESS) with 3 Tesla

Welsch

Scheffler

Mamisch

et al. 2009

Magnetic Resonance in Med

137

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The double-echo-steady-state (DESS) sequence generates two signal echoes that are characterized by a different contrast behavior. Based on these two contrasts, the underlying T2 can be calculated. For a flip-angle of 90°, the calculated T2 becomes independent of T1, but with very low signal-to-noise ratio. In the present study, the estimation of cartilage T2, based on DESS with a reduced flip-angle, was investigated, with the goal of optimizing SNR, and simultaneously minimizing the error in T2. This approach was validated in phantoms and on volunteers. T2 estimations based on DESS at different flipangles were compared with standard multiecho, spin-echo T2. Furthermore, DESS-T2 estimations were used in a volunteer and in an initial study on patients after cartilage repair of the knee. A flip-angle of 33°was the best compromise for the combination of DESS-T2 mapping and morphological imaging.

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MR imaging of osteochondral grafts and autologous chondrocyte implantation

Cited by 169 publications

References 73 publications

Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

Quantitative and topographical evaluation of ankle articular cartilage using high resolution MRI

Rapid estimation of cartilage T2 based on double echo at steady state (DESS) with 3 Tesla

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