“…The last search through PubMed was conducted on December 1, 2018. The publication times of the literature on iCNS‐LYG cases ranged from 1984 to 2018, including 37 articles and 48 patients . The total number of cases was 49, including the one case reported by us in this study.…”
Section: Resultsmentioning
confidence: 93%
“…In the imaging examinations of LYG, punctate or linear enhancement is a relatively characteristic feature, which is related to the pathological feature of the disease, involving primarily the vascular wall and perivascular tissues. The patient admitted to our hospital exhibited this feature.…”
Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoproliferative disease which can involve multiple organs of the body and is most common in the lungs. Its pathological features are proliferation of large atypical B‐cells related to Epstein–Barr virus, T‐cell infiltration and tissue necrosis. This disease is rare, and LYG which uniquely involves the central nervous system (CNS) is extremely rare. In this paper, we report a case of isolated lymphomatoid granulomatosis of the CNS (iCNS‐LYG) diagnosed by histological biopsy and we review the clinical features of all similar cases reported in the past 46 years. A total of 49 cases of iCNS‐LYG have been reported to date. The clinical, imaging and pathological features of iCNS‐LYG are discussed in combination with a literature review.
“…The last search through PubMed was conducted on December 1, 2018. The publication times of the literature on iCNS‐LYG cases ranged from 1984 to 2018, including 37 articles and 48 patients . The total number of cases was 49, including the one case reported by us in this study.…”
Section: Resultsmentioning
confidence: 93%
“…In the imaging examinations of LYG, punctate or linear enhancement is a relatively characteristic feature, which is related to the pathological feature of the disease, involving primarily the vascular wall and perivascular tissues. The patient admitted to our hospital exhibited this feature.…”
Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoproliferative disease which can involve multiple organs of the body and is most common in the lungs. Its pathological features are proliferation of large atypical B‐cells related to Epstein–Barr virus, T‐cell infiltration and tissue necrosis. This disease is rare, and LYG which uniquely involves the central nervous system (CNS) is extremely rare. In this paper, we report a case of isolated lymphomatoid granulomatosis of the CNS (iCNS‐LYG) diagnosed by histological biopsy and we review the clinical features of all similar cases reported in the past 46 years. A total of 49 cases of iCNS‐LYG have been reported to date. The clinical, imaging and pathological features of iCNS‐LYG are discussed in combination with a literature review.
“…By further application of strict inclusion and exclusion criteria, 14 articles were included in our final analysis ( Figure 3 ). 1 , 2 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 In this study, 15 cases, including our 1 case, were investigated ( Table 1 ). Figure 3 Systematic literature search for spinal lymphomatoid granulomatosis according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.…”
Section: Systematic Review Of Resultsmentioning
confidence: 99%
“…Lymphomatoid granulomatosis (LYG) is a rare EBV-associated systemic angiocentric and angiodestructive lymphoproliferative disorder that commonly involves the lungs (the initial site of manifestation in >90% of patients), skin (40%−50% of patients), liver, kidney, and central nervous system (CNS). 1 , 2 , 3 , 4 …”
Section: Introductionmentioning
confidence: 99%
“…CNS LYG accounts for approximately 30% of all LYG cases. 1 In most of these cases, the site of CNS LYG is in the brain, and LYG occurring in the spinal cord is rare. 5 However, the details on CNS LYG are unknown.…”
Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus−associated systemic angiocentric and angiodestructive lymphoproliferative disorder. It commonly involves the lungs and can also affect the skin, liver, kidney, and central nervous system. It can rarely occur in the spine, however, the details are unclear. We performed a systematic review of published cases (including our 1 case) of spinal LYG.
We performed a systematic search of studies in English on spinal LYG, focusing on its clinical features, imaging, and treatments, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines on the PubMed database. We identified 14 patients from the literature. We also found 1 case of isolated cervical LYG (grade 3) who was treated with steroid and radiation therapy for the spinal lesion after pathologic diagnosis. We performed a pooled analysis of these 15 cases.
The mean age was 43.4 years, and 13 of the 15 patients were male. Brain lesions were present in 11 of 12 intramedullary spinal lesions, and only 1 was an isolated spinal LYG case. Regarding the diagnostic methods, 1 case was not described. Of the 14 cases described, 12 patients underwent biopsies (7 brain, 4 lung, and 1 spinal cord lesion) and 2 underwent surgical removal for an extramedullary lesion. In the overall prognosis from a mean follow-up period of 21.6 months, 4 patients died despite several treatments.
Spinal LYG, particularly isolated spinal LYG, is rare. Thus further accumulation of cases may be necessary to better understand its characteristics.
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