MR Imaging of the Heart in Patients after Myocardial Infarction: Effect of Increasing Intersection Gap on Measurements of Left Ventricular Volume, Ejection Fraction, and Wall Thickness

Cottin, Yves; Touzery, Claude; F, Guy; Lalande, Alain; Ressencourt, Olivier; S, Roy; Walker, Paul; Louis, P; Brunotte, François; Wolf, Jean-Éric

doi:10.1148/radiology.213.2.r99nv38513

Cited by 41 publications

(32 citation statements)

References 39 publications

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“…As there was no clinically relevant difference in heart rate during the acquisition of protocols A, B, and C, the physiologic variation in heart rate, SV, and thus cardiac output can be ruled out as a possible cause for the difference in EDV and consequently in SV between the protocols. We chose to acquire contiguous slices with a thickness of 8 mm due to signal-to-noise ratio (SNR) considerations for the real-time measurement, although intersection gaps of 5 mm do not compromise the accuracy of short axis ventriculometry using a slice thickness of 5 mm (26).…”

Section: Discussionmentioning

confidence: 99%

Assessment of left ventricular function by breath‐hold cine MR imaging: Comparison of different steady‐state free precession sequences

Kunz

Oellig

Krummenauer

et al. 2005

Magnetic Resonance Imaging

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Purpose:To compare steady-state free precession (SSFP) sequence protocols with different acquisition times (TA) and temporal resolutions (tRes) due to the implementation of a view sharing technique called shared phases for the assessment of left ventricular (LV) function by breath-hold cine magnetic resonance (MR) imaging. Materials and Methods:End-diastolic and end-systolic volumes (EDV, ESV) were measured in contiguous shortaxis slices with a thickness of 8 mm acquired in 10 healthy male volunteers. The following true fast imaging with steady-state precession (TrueFISP) sequence protocols were compared: protocol A) internal standard of reference, segmented: tRes 34.5 msec, TA 18 beats per slice; protocol B) segmented, shared phases: tRes 34.1 msec, TA 10 beats per slice; and protocol C) real-time, shared phases, parallel acquisition technique: tRes 47.3 msec, TA 24 beats for 12 slices covering the entire left ventricle. Results:Phase sharing leads to a significant decrease in EDV, stroke volume (SV), and ejection fraction (EF) (median difference -7.0 mL [*], -9.6 mL, and -3.4%, respectively, for protocol B; -15.3 mL, -13.3 mL, and -2.4% for protocol C; P ϭ 0.002, *P ϭ 0.021). The observed median difference of real-time EDV and SV estimates is of clinical relevance. Real-time cine MR imaging shows a greater variability of EDV and SV. No relevant differences in ESV were observed. Conclusion:The true cine frame duration of both shared phases sequence protocols exceeds the period of isovolumetric contraction (IVCT) of the left ventricle resulting in a systematic and significant underestimation of EDV and consequently SV and EF. SSFP sequence protocol parameters, particularly tRes and use of view sharing techniques, should therefore be known at follow-up examinations in order to be able to assess LV remodeling in patients with heart failure. CINE MAGNETIC RESONANCE (MR) imaging has beenshown to be the most accurate and reproducible method for the evaluation of cardiac ventricular volumes, function, and mass and is therefore regarded to be the standard of reference (1-4). Two different MR sequences are commonly used to assess cardiac function parameters non-invasively: segmented k-space turbo gradient echo (TGE) and steady-state free precession (SSFP) sequences.The accuracy of segmented k-space TGE sequences has been extensively evaluated, including animal experiments (5-8). The recently introduced SSFP sequences enable shorter acquisition times, allow higher in-plane resolutions, and provide better image quality (8,9). Their accuracy in determining left ventricular (LV) mass was also evaluated in animal experiments (10). Normal values were established for left and right ventricular volumes and function for both TGE as well as SSFP sequences, with SSFP sequences yielding significantly larger end-diastolic and end-systolic volumes (EDV and ESV, respectively) than TGE sequences (7,8,(11)(12)(13)(14)(15)(16)(17).Signal intensity in images acquired with SSFP sequences relies on T2/T1 ratio and does not depend on inflow...

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Section: Discussionmentioning

confidence: 99%

Assessment of left ventricular function by breath‐hold cine MR imaging: Comparison of different steady‐state free precession sequences

Kunz

Oellig

Krummenauer

et al. 2005

Magnetic Resonance Imaging

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show abstract

Section: Discussionmentioning

confidence: 99%

“…32. In a group of 61 patients with myocardial infarction, Cottin et al (32) showed that with the use of 5-mm-thick contiguous cross sections, MRI can be one of the most precise methods for quantitatively assessing the cardiovascular system. They also concluded that SA imaging is more accurate than other methods based on geometric assumptions about the LV shape (e.g., the hemisphere cylinder, biplane ellipsoid, and horizontal and vertical LA plane).…”

Section: Discussionmentioning

confidence: 99%

Influence of positional and angular variation of automatically planned short‐axis stacks on quantification of left ventricular dimensions and function with cardiovascular magnetic resonance

Danilouchkine

Geest

Westenberg

et al. 2005

Magnetic Resonance Imaging

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Purpose: To theoretically and experimentally investigate the influence of the automated cardiovascular magnetic resonance (CMR) scan planning pitfalls, namely inaccurate positioning and tilting of short-axis (SA) imaging planes, on quantification of the left ventricular (LV) dimensions and function. Materials and Methods:Eleven healthy subjects and eight patients underwent CMR. Manually and automatically planned SA sets were acquired. To obtain the quantitative measurements of LV function, one observer performed image analysis twice. The agreement between planning methods, as well as the decomposition of the total variation into interstudy and intraobserver components was measured. Results:The decomposition of the total variation showed that the interstudy factor accounts for 70 -85% of the total variation, while the rest is due to the intraobserver factor. Moreover, the relative contribution of the interstudy factor remains independent from errors in slice positioning and small angular deviation of SA stacks from the optimal orientation. Good agreement between the theoretical and measured variability factors was observed. Conclusion:Global LV function derived from the automatically planned CMR acquisitions yield accurate quantification of the human cardiovascular system. Inaccurate positioning and tilting of SA images does not affect the quantitative measurements of LV function. The computeraided system for automated CMR has proven clinical applicability.

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“…To do so, the surface demarcated by the LV contour was calculated on each image of the cine-MRI. Consequently, the LV volume was computed as the summation of the cavity areas multiplied by thickness of the section interval [18]. Since the extreme basal slice cannot be used for contour determination, the small but significant distance separating the last usable slice and the level of the valves was considered instead.…”

Section: Methodsmentioning

confidence: 99%

Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

et al. 2013

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Objectives: This study investigates the effect of aging on the radial viscoelastic behavior of the left ventricle (LV) based on a previously validated model that uses myocardial tissue phase mapping (TPM) of cine phase-contrast MRI. Methods: Previous studies suggest that aging remarkably influences regional myocardial motion, mostly myocardial velocities in both radial and long-axis directions. However, the effect of aging on cardiac viscoelasticity, which exhibits time-dependent strain, has not been elucidated yet. In this study, myocardial velocity and displacement mapping of the LV was performed using TPM in 39 healthy subjects divided into three age groups. The viscoelasticity parameters were obtained for each segment of the LV and compared among the studied groups. Results: The analyses showed that myocardial elasticity ranged from approximately 20 to -20 dyne/cm² during a cardiac cycle, and the myocardial viscous-damping component ranged from -1 to 1 dyne × s/cm². Overall, no statistically significant difference was observed in the viscoelasticity components among the subjects in the different age groups (p > 0.05). Conclusion: Myocardial viscoelastic behavior of the LV in radial direction was found to be considerably similar in pattern and magnitude among the studied subjects of different age groups with no statistically significant difference, despite the fact that the regional myocardial velocities change due to aging.

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MR Imaging of the Heart in Patients after Myocardial Infarction: Effect of Increasing Intersection Gap on Measurements of Left Ventricular Volume, Ejection Fraction, and Wall Thickness

Abstract: In the study of left ventricles with heterogeneous contractility, short-axis imaging is more accurate than geometric modeling and permits wall thickness measurements when an intersection gap of 5 or 10 mm is used.

Cited by 41 publications

References 39 publications

Assessment of left ventricular function by breath‐hold cine MR imaging: Comparison of different steady‐state free precession sequences

Assessment of left ventricular function by breath‐hold cine MR imaging: Comparison of different steady‐state free precession sequences

Influence of positional and angular variation of automatically planned short‐axis stacks on quantification of left ventricular dimensions and function with cardiovascular magnetic resonance

Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

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