MR imaging patterns of gadolinium retention within liver neoplasms

Peterson, Mark S.; Murakami, Takamichi; Baron, Richard L.

doi:10.1007/s002619900410

Cited by 33 publications

(11 citation statements)

References 21 publications

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“…The tumor may become isointense or mildly hyperintense compared to the surrounding liver parenchyma on delayed gadolinium-enhanced imaging (Fig. 1) [46]. Four patterns of enhancement of cholangiocarcinoma have been described on early (30 s), late (1 and 3 min) and delayed (5 min) post-gadolinium imaging [2, 36, 37]:

Early peripheral enhancement with progressive and concentric filling in, which is the most common enhancement pattern.

…”

Section: Imagingmentioning

confidence: 99%

Magnetic resonance imaging of cholangiocarcinoma

Vanderveen¹

2004

Cancer Imaging

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Preoperative imaging with MRI/MRA/MRCP is an accurate non-invasive method for staging cholangiocarcinoma, and determining resectability. It provides information regarding tumor size, extent of bile duct involvement, vascular patency, extrahepatic extension, nodal or distant metastases, and the presence of lobar atrophy. MRCP is better for demonstrating bile ducts distal to the stricture, although with ERCP, therapeutic intervention such as stent placement and biopsy can be performed.

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Early peripheral enhancement with progressive and concentric filling in, which is the most common enhancement pattern.

…”

Section: Imagingmentioning

confidence: 99%

Magnetic resonance imaging of cholangiocarcinoma

Vanderveen¹

2004

Cancer Imaging

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“…This tumor resembles a mass-forming ICC on contrastenhanced computed tomography and magnetic resonance imaging (MRI), appearing as ill-marginated, noncapsulated tumors with lobulating contour displaying peripheral rim enhancement on the early dynamic phase, followed by progressive and concentric filling with contrast material. 4,[11][12][13][14] Considering that scirrhous HCC and ICC are the most common primary liver malignancies with abundant fibrosis, constituting approximately 4% 7,11 and 5% to 10% of primary liver malignancies, 4 and that each tumor requires different treatment strategies, it is important to precisely differentiate these 2 tumors.…”

mentioning

confidence: 99%

Scirrhous Hepatocellular Carcinoma on Gadoxetic Acid–Enhanced Magnetic Resonance Imaging and Diffusion-Weighted Imaging

Park

Kim

Park

et al. 2013

Journal of Computer Assisted Tomography

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“…Cholangiocarcinomas appear hypointense on T 1 -weighted images and hyperintense on T 2 -weighted images. Image enhancement can be observed using superparamagnetic iron and delayed gadolinium images (47,48). MR angiography can be performed to assess vascular encasement (49).…”

Section: Diagnosismentioning

confidence: 99%

Cholangiocarcinoma: Modern advances in understanding a deadly old disease

Malhi

Gores

2006

Journal of Hepatology

243

193

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Cholangiocarcinomas are tumors that arise anywhere in the biliary tract, presumably of cholangiocyte origin. The global incidence of this rare disease is on the rise. Several known risk factors exist, and link chronic biliary inflammation to the pathogenesis of cholangiocarcinoma. Among these, amplification of the epidermal growth factor receptor, the interleukin-6 signaling pathway, inducible nitric oxide, erb-2, and cyclooxygenase-2 are well defined. Most patients present late, with a median survival of months. Although, imaging studies and clinical context often indicate cholangiocarcinoma, pathologic and cytologic diagnosis is difficult to obtain. Advanced cytologic tests with fluorescent in situ hybridization or digital image analysis can increase diagnostic sensitivity. Surgical resection is the current therapy of choice for both intrahepatic and ductal cholangiocarcinomas. However, the 5 year survival is poor, with 60 to greater than 90% recurrence rates. In a single center experience, liver transplantation with neoadjuvant chemoirradiation, for highly selected patients has a 5 year disease free survival of greater than 80%. Future targeted therapies will depend on a better understanding of the cellular and molecular biology of cholangiocarcinomas.

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MR imaging patterns of gadolinium retention within liver neoplasms

Abstract: Homogeneous gadolinium retention on delayed postcontrast images of malignant hepatic neoplasms is seen in a high percentage of CCA lesions and less commonly with other neoplasms.

Cited by 33 publications

References 21 publications

Magnetic resonance imaging of cholangiocarcinoma

Magnetic resonance imaging of cholangiocarcinoma

Scirrhous Hepatocellular Carcinoma on Gadoxetic Acid–Enhanced Magnetic Resonance Imaging and Diffusion-Weighted Imaging

Cholangiocarcinoma: Modern advances in understanding a deadly old disease

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