MR imaging to detect myelolipomas of the liver

Xin, Huizhen; Li, Hai-Jun; Yu, Honghui; Zhang, Juan; Peng, Weizhi; Peng, Dechang

doi:10.1097/md.0000000000016497

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…In addition, Golgi protein (GP)-73 is also a common diagnostic marker for liver cancer, which presents an extremely low or no expression in hepatocytes and high expression in hepatocytes infected with hepatitis B virus or adenovirus. Previous studies have reported higher sensitivity but lower specificity of GP-73 than AFP assay in the early diagnosis of PLC [ 12 , 13 ]. Currently, there is no report on the application of MRI combined with AFP-L3 and GP-73 in the diagnosis of primary liver cancer in China.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging and Serum AFP-L3 and GP-73 in the Diagnosis of Primary Liver Cancer

Yuan

Xu²,

et al. 2022

Journal of Oncology

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Objective. To investigate the combined application value of magnetic resonance imaging (MRI) combined with serum alpha-fetoprotein (AFP)-L3 and Golgi protein (GP)-73 in the diagnosis of primary liver cancer. Methods. The data of 200 patients with suspected liver cancer admitted to our hospital from February 2020 to February 2021 were retrospectively analyzed, and they were randomly divided into an experimental group and a control group, with 100 cases in each group. The experimental group received a combined detection of MRI with serum AFP-L3 and GP-73, and the control group adopted traditional diagnostic methods (spiral computed tomography and serum AFP). The diagnostic yields of the two groups were compared. Surgical resection was performed after the diagnosis of primary liver cancer, and the correlation between the efficacy and combined detection of MRI with serum AFP-L3 and GP-73 levels was analyzed. Results. The two groups presented comparable general information (P >0.05). The surgical results showed 160 cases of primary liver cancer, including 75 cases in the experimental group and 85 cases in the control group, and 40 cases of benign liver lesions. The diagnostic accuracy of the experimental group (73/75, 95%) was significantly higher than that of the control group (76/85, 86%) ( P < 0.05 ). The serum levels of AFP-L3, GP-73, and AFP in patients with primary liver cancer were remarkably decreased after surgery ( P < 0.001 ). The preoperative and postoperative AFP-L3, GP-73, and AFP levels of patients with primary liver cancer were significantly higher than those of patients with benign liver lesions. The AUC (95% CI) for the combined detection of MRI and serum AFP-L3 and GP-73 levels in patients with surgically confirmed primary liver cancer was 0.747 (0.619-0.874). Conclusion. MRI combined with serum AFP-L3 and GP-73 presents favorable diagnostic efficiency in the diagnosis of primary liver cancer, which is worthy of clinical application.

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Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging and Serum AFP-L3 and GP-73 in the Diagnosis of Primary Liver Cancer

Yuan

Xu²,

et al. 2022

Journal of Oncology

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“…The etiology of hepatic myelolipoma is unknown, but several hypotheses exist. Among the most promising ideas are that it is due to an ectopic adrenal gland, an alteration of hepatocytes, or embryonic stem cells remaining in the liver[ 1 , 4 ]. Extra-adrenal myelolipomas tend to occur after middle age, with a male-to-female ratio of 1:2[ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among the most promising ideas are that it is due to an ectopic adrenal gland, an alteration of hepatocytes, or embryonic stem cells remaining in the liver[ 1 , 4 ]. Extra-adrenal myelolipomas tend to occur after middle age, with a male-to-female ratio of 1:2[ 4 ]. Myelolipoma is usually asymptomatic in the case of a small lesion, but spontaneous rupture due to mass effect, acute abdomen, and bleeding may occur as the lesion grows[ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…When the lesion develops outside the adrenal gland, it is most often detected in the anterior sacral region[ 1 ]. According to previous reports, myelolipomas of liver origin are lesions with fatty and soft tissue density components accompanied by capsular-like structures[ 2 - 4 ]. Therefore, it is crucial to differentiate it from other tumors, including hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Indium chloride bone marrow scintigraphy for hepatic myelolipoma: A case report

Sato¹,

Saito²,

Abe³

et al. 2023

World J Clin Cases

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BACKGROUND As hepatic myelolipoma is rarely encountered, its radiological diagnosis using ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) is challenging. Hepatic myelolipoma is similar to fat-contained hepatic lesions seen in hepatocellular carcinoma and angiomyolipoma. Therefore, further development of techniques to diagnose hepatic myelolipoma is warranted. CASE SUMMARY A 44-year-old obese man was found to have a hepatic lesion during his medical checkup. The lesion was 50 mm × 57 mm in size and was detected in segment 8 (S8) of the liver by US. The patient was diagnosed with hepatic lesion 20 years ago, but it was left unresolved. The patient had no symptoms, liver dysfunction, hepatitis virus antibody, or tumor marker elevation. Plain CT showed a well-defined lesion in S8 of the liver. The central and peripheral areas of the lesion primarily exhibited fat density and hypodensity, respectively. MRI revealed a capsule-like structure. Biopsy was performed to address the probability of hepatocellular carcinoma. The lesion was pathologically confirmed as a myelolipoma. Bone marrow scintigraphy performed using 111 InCl 3 revealed accumulation of the radiopharmaceutical in the soft tissue component, except in the fat-dominant part of the tumor, as well as in the surrounding liver parenchyma due to the presence of reticuloendothelial cells in the liver. CONCLUSION This is the first report on the diagnosis of hepatic myelolipoma using 111 InCl 3 scintigraphy. The effectiveness of bone marrow scintigraphy for diagnosing hepatic myelolipoma might be limited. As radiopharmaceuticals accumulate in both hematopoietic and reticuloendothelial cells, the accumulation of radiopharmaceuticals in the lesion is obscure.

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“…The non-enhanced CT attenuation of fatty lesions in the liver is lower than 40 HU or at least 10 HU lower than that of the spleen [ 4 5 ]. These lesions may show variations depending on the proportion of fat and other components [ 7 8 ]; therefore, histopathological analysis is needed to confirm fatty lesions.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic imaging features of hepatic myelolipoma incarcerated in a peritoneopericardial diaphragmatic hernia in a cat

2022

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A 1-year-old male Persian cat was presented for castration. Liver incarcerated in a peritoneopericardial diaphragmatic hernia (PPDH) was diagnosed through pre-anesthetic tests. Multiple homogeneous hyperechoic nodules in the hepatic parenchyma were identified using ultrasound. The nodules showed decreased attenuation compared with normal hepatic parenchyma, and the herniated hepatic parenchyma showed increased arterial and decreased portal enhancement on computed tomography. From the histopathology, we diagnosed hydropic degeneration with portal fibrosis and myelolipoma. This report presents diagnostic imaging features of hepatic myelolipoma incarcerated in a PPDH in a cat. When perfusion of the hepatic parenchyma is altered, surgical treatment should be considered.

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MR imaging to detect myelolipomas of the liver

Cited by 6 publications

References 16 publications

Magnetic Resonance Imaging and Serum AFP-L3 and GP-73 in the Diagnosis of Primary Liver Cancer

Magnetic Resonance Imaging and Serum AFP-L3 and GP-73 in the Diagnosis of Primary Liver Cancer

Indium chloride bone marrow scintigraphy for hepatic myelolipoma: A case report

Diagnostic imaging features of hepatic myelolipoma incarcerated in a peritoneopericardial diaphragmatic hernia in a cat

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