MR-mammographische Beurteilung des Tumoransprechverhaltens nach neoadjuvanter Radiochemotherapie lokal fortgeschrittener Mammakarzinome

Kurtz, B; Achten, Ch.; Audretsch, Werner; Rezai, Mahdi; Urban, Patrick; Zocholl, G.

doi:10.1055/s-2007-1015691

Cited by 10 publications

(1 citation statement)

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“…Knopp et al[25] beschrieben eine Abflachung der Signalintensitätskurve bereits nach zwei Chemotherapiezyklen als Zeichen des Ansprechens auf die Chemotherapie. Auch Kurtz et al[13] berichten von einer Veränderung des Kurventyps unter Therapie, nämlich von einer malignomtypisch steilen hin zu einer stetig ansteigenden Kurve. Wir konnten in unserem Kollektiv nach den ersten beiden Chemotherapiezyklen diesen Befund nicht in allen Fällen nachvollziehen.…”

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MR-Mammographie zur Responsekontrolle bei primärer Chemobrachytherapie des BET-inoperablen Mammakarzinoms

Hlawatsch¹,

Kuner²,

Teifke³

et al. 2001

Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr

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MR-Mammographie zur Responsekontrolle bei primärer Chemobrachytherapie des BET-inoperablen Mammakarzinoms

Hlawatsch¹,

Kuner²,

Teifke³

et al. 2001

Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr

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Dynamic image interpretation of MRI of the breast

Kuhl

Schild

2000

J. Magn. Reson. Imaging

194

132

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Dynamic breast MRI provides information on both lesion cross-sectional morphology and functional lesion features such as vascularity/perfusion and vessel permeability. This review gives an overview of the historical background of dynamic contrast-enhanced breast MRI. It explains the technique's pathophysiological basis, describes the various technical approaches that have been pursued and the corresponding interpretation guidelines that have been proposed (including their respective diagnostic accuracies), and presents established and evolving clinical applications of the "dynamic approach" to breast MRI.

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Monitoring the therapeutic response of locally advanced breast cancer patients: Sequential in vivo proton MR spectroscopy study

Kumar

Jagannathan

Seenu

et al. 2006

Magnetic Resonance Imaging

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PurposeTo evaluate the use of the water‐to‐fat (W‐F) value obtained from in vivo proton (1H) MR spectroscopy (MRS) as a response indicator of cytologically confirmed patients with locally advanced breast cancer (LABC), and to monitor the therapeutic response of such patients to neoadjuvant chemotherapy (NACT)Materials and MethodsSerial 1H MR spectra were recorded both before and after the completion of chemotherapy in 33 LABC patients (with infiltrating ductal carcinoma (IDC)) at 1.5T. In addition, spectra from normal breast tissues of 28 healthy volunteers were recorded.ResultsMalignant breast tissues showed elevated W‐F values compared to normal breast tissues of controls. Statistically significant higher pretherapy W‐F value (P < 0.01) was observed in patients compared to controls. In patients who received NACT resulting in the reduction of the primary tumor size, the W‐F value showed a decrease that was statistically significant (P < 0.01). Analysis of the MR data further indicates that the W‐F value had no correlation with the menstrual status of the patients. A comparison of pretherapy W‐F value with pretherapy tumor volume showed a fair correlation (P = 0.05), while the posttherapy W‐F value showed no such correlation with the posttherapy tumor volume.ConclusionThis study demonstrates that simple, conventional in vivo 1H MRS is a useful technique for monitoring the therapeutic response of breast cancer patients. The observed trend in the reduction of W‐F value provides a noninvasive response indicator to monitor the clinical outcome of locally advanced breast cancer patients to NACT J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.

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MR-mammographische Beurteilung des Tumoransprechverhaltens nach neoadjuvanter Radiochemotherapie lokal fortgeschrittener Mammakarzinome

Cited by 10 publications

References 0 publications

MR-Mammographie zur Responsekontrolle bei primärer Chemobrachytherapie des BET-inoperablen Mammakarzinoms

MR-Mammographie zur Responsekontrolle bei primärer Chemobrachytherapie des BET-inoperablen Mammakarzinoms

Dynamic image interpretation of MRI of the breast

Monitoring the therapeutic response of locally advanced breast cancer patients: Sequential in vivo proton MR spectroscopy study

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