MR monitoring of focused ultrasound surgery in a breast tissue model in vivo

Bohris, Christian; Jenne, Jürgen; Rastert, R.; Simiantonakis, Ioannis; Brix, Gunnar; Spoo, J.; Hlaváč, Michal; Naeije, Robert; Huber, Peter E.; Debus, Jürgen

doi:10.1016/s0730-725x(01)00229-6

Cited by 37 publications

(20 citation statements)

References 21 publications

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“…Hynynen et al (1993) studied the feasibility of using magnetic resonance imaging (MRI) to detect tissue necrosis induced by focused ultrasound beam. Methods to monitor temperature changes with MRI in the target region have been also investigated (Bohris et al 2001;Cline et al 1994). Although MRI has a superior contrast between necrotic and normal tissue and was considered to be quite adept at guiding focused ultrasound surgery, MRI is expensive and not portable and it has poor temporal resolution (a few seconds).…”

Section: Introductionmentioning

confidence: 99%

Monitoring imaging of lesions induced by high intensity focused ultrasound based on differential ultrasonic attenuation and integrated backscatter estimation

Zhong

Wan

Jiang

et al. 2007

Ultrasound in Medicine & Biology

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Section: Introductionmentioning

confidence: 99%

Monitoring imaging of lesions induced by high intensity focused ultrasound based on differential ultrasonic attenuation and integrated backscatter estimation

Zhong

Wan

Jiang

et al. 2007

Ultrasound in Medicine & Biology

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“…Similar lesions in the rabbit brain [61,62] and synovial tissue [63] also showed excellent correlation with size determined histologically using triphenyl tetrazolium chloride staining for cell viability, using both light and electron microscopy [64]. T 2 -w imaging was also able to detect lesions in an in vivo sheep model of breast tissue [65] and in human breast [66]. Clinical trials also used T 2 -w imaging to guide the treatment, with the tumour appearing hyperintense relative to the surrounding tissue.…”

Section: Diagnostic Ultrasound Monitoringmentioning

confidence: 82%

“…Ultimately, they were also able to demonstrate fast 3D thermometry [139]. To date, PRF thermometry guided focused ultrasound has been developed for the clinical treatment of uterine leiomyosarcomas (fibroids) [140,141], brain tissue [71] and breast tumours [65,66]. An example of such use is shown in Figure 4.…”

Section: Proton Resonant Frequencymentioning

confidence: 99%

Treatment monitoring and thermometry for therapeutic focused ultrasound

Rivens

Shaw

Civale

et al. 2007

International Journal of Hyperthermia

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Therapeutic ultrasound is currently enjoying increasingly widespread clinical use especially for the treatment of cancer of the prostate, liver, kidney, breast, pancreas and bone, as well as for the treatment of uterine fibroids. The optimum method of treatment delivery varies between anatomical sites, but in all cases monitoring of the treatment is crucial if extensive clinical acceptance is to be achieved. Monitoring not only provides the operating clinician with information relating to the effectiveness of treatment, but can also provide an early alert to the onset of adverse effects in normal tissue. This paper reviews invasive and non-invasive monitoring methods that have been applied to assess the extent of treatment during the delivery of therapeutic ultrasound in the laboratory and clinic (follow-up after treatment is not reviewed in detail). The monitoring of temperature and, importantly, the way in which this measurement can be used to estimate the delivered thermal dose, is dealt with as a separate special case. Already therapeutic ultrasound has reached a stage of development where it is possible to attempt real-time feedback during exposure in order to optimize each and every delivery of ultrasound energy. To date, data from MR imaging have shown better agreement with the size of regions of damage than those from diagnostic ultrasound, but novel ultrasonic techniques may redress this balance. Whilst MR currently offers the best method for non-invasive temperature measurement, the ultrasound techniques under development, which could potentially offer more rapid visualisation of results, are discussed.

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“…In the early 1990s, Hynynen et al (1993) studied the feasibility of using MRI to detect tissue necrosis induced by a focused ultrasound beam. MRI methods for monitoring temperature changes in the target region have also been investigated (Bohris et al 2001;Cline et al 1994). Because of its good performance in temperature mapping and superior contrast between necrotic and normal tissues, MR-guided focused ultrasound surgery has been applied in some clinical fields (Chapman and ter Haar 2007;Furusawa et al 2006).…”

Section: Magnetic Resonance Cavitation Imagingmentioning

confidence: 99%