MR-morphologische Veränderungen der Metacarpophalangealgelenke bei Rheumatoider Arthritis: Vergleich früher und später Stadien

Scherer, A.; Ostendorf, Benedikt; Engelbrecht, V.; Poll, L. W.; Becker, Aimee; Dann, P.; Peters, Ricardo; Schneider, M.; Mödder, Ulrich

doi:10.1055/s-2001-17582

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…Ursachen hierfür sind die hohe Sensitivität der MRT für den frühen Nachweis weichteiliger und knöcherner Gelenkpathologien und die Beurteilung der Krankheitsaktivität durch die Applikation von Kontrastmittel [4,5]. Eine besondere prognostische Bedeutung für die Ausbildung von erosiven Gelenkdestruktionen wird hierbei dem Knochenödem zugeschrieben, welches nur mit der MRT nachgewiesen werden kann.…”

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Knöcherne Pathologien der Metacarpophalangeal-Gelenke bei früher rheumatoider Arthritis: Vergleich zwischen MRT und hochauflösender SPECT

Scherer¹,

Wirrwar²,

Mattes-György³

et al. 2009

Fortschr Röntgenstr

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Knöcherne Pathologien der Metacarpophalangeal-Gelenke bei früher rheumatoider Arthritis: Vergleich zwischen MRT und hochauflösender SPECT

Scherer¹,

Wirrwar²,

Mattes-György³

et al. 2009

Fortschr Röntgenstr

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“…Ein standardisiertes Untersuchungsprotokoll für die Hand bei RA existiert bis dato nicht, doch aus dem Spektrum der Pulssequenzen haben sich jedoch einige Sequenzen herauskristallisiert, die obligat zur Anwendung kommen sollten(15,16,34). Es sollten ausschließlich dedizierte, anatomisch angepasste Spulen mit zirkulärer Polarisation verwendet werden, die für die jeweilige Region eine optimale Bildqualität liefern (z.…”

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Bildgebende Verfahren in der Rheumatologie: Magnetresonanztomographie bei Rheumatoider Arthritis

et al. 2003

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A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritis

Scheel¹,

Hermann²,

Kahler³

et al. 2005

Arthritis & Rheumatism

238

187

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Objective. To develop an ultrasonographic (US) synovitis scoring system suitable for evaluation of finger joint inflammation in patients with active rheumatoid arthritis (RA) and to compare semiquantitative US scoring with quantitative US measurements.Methods. US was performed at the palmar and dorsal sides of the second through fifth metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in 10 healthy subjects and in the clinically more affected hand in 46 RA patients. Ten patients additionally underwent magnetic resonance imaging (MRI). Synovitis was measured, standardized, and scored according to a semiquantitative method. The 2 methods (semiquantitative US scoring, quantitative US) were compared and statistical cutoffs were identified using receiver operating characteristic (ROC) curve analysis. MRI results were compared with semiquantitative US scoring and quantitative US results. The optimal US scoring method from 6 joint combinations was identified (ROC curve analysis).Results. Synovitis was most frequently detected in the palmar proximal area (86% of affected joints). We found no significant differences between individual PIP joints or between individual MCP joints, indicating that all fingers within each of these joint groups should be treated equally for statistical calculations, although each joint group as a whole should be treated separately. The optimal cutoff point to distinguish between "health" and "pathology" was 0.6 mm both for MCP joints (sensitivity 94%, specificity 89%) and for PIP joints (sensitivity 90%, specificity 88%). There was no significant difference between semiquantitative US scores and quantitative US measurements. The best results for joint combinations were achieved using the "sum of 4 fingers" (second through fifth MCP and PIP joints) and "sum of 3 fingers" (second through fourth MCP and PIP joints) methods. Comparison of MRI results with semiquantitative US scores revealed high concordance.Conclusion. US evaluation of finger joint synovitis can be considerably simplified by focusing on the palmar side and by applying semiquantitative grading instead of quantitative measurements. For evaluation of treatment efficacy based on synovitis in RA patients, we recommend using the "sum of 3 fingers" method in longitudinal trials.

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MR-morphologische Veränderungen der Metacarpophalangealgelenke bei Rheumatoider Arthritis: Vergleich früher und später Stadien

Abstract: In RA patients, MRI of the metacarpophalangeal joints can detect specific pathological changes which are observed significantly more often in either early or chronic stages and which are associated with disease activity and duration.

Cited by 7 publications

References 13 publications

Knöcherne Pathologien der Metacarpophalangeal-Gelenke bei früher rheumatoider Arthritis: Vergleich zwischen MRT und hochauflösender SPECT

Knöcherne Pathologien der Metacarpophalangeal-Gelenke bei früher rheumatoider Arthritis: Vergleich zwischen MRT und hochauflösender SPECT

Bildgebende Verfahren in der Rheumatologie: Magnetresonanztomographie bei Rheumatoider Arthritis

A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritis

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