MR pulse wave velocity increases with age faster in the thoracic aorta than in the abdominal aorta

Devos, Daniël; Rietzschel, Ernst; Heyse, Catherine; Vandemaele, Pieter; Bortel, Luc Van; Babin, Danilo; Segers, Patrick; Westenberg, Jos; Achten, Rik

doi:10.1002/jmri.24592

Cited by 26 publications

(26 citation statements)

References 42 publications

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“…The similar growth of proximal and distal sections entails a reduction of pulse pressure amplification with age, as found in several clinical studies [22,24,31,[45][46][47]. Moreover, the increase of characteristic impedance along the aorta is dampened with age [48]: from 20 to 80 years of age, abdominal values of Z C change from being 8 to 5 times the characteristic impedance at the aortic root and, in particular, in the thoracic aorta the increase reduces from +150% to +80% in the same age range (see panel 3d). It follows that the spatial gradient of systolic pressure upstream the thoracic aorta is reduced, contributing (from upstream) to smooth away the peak.…”

Section: Resultssupporting

confidence: 62%

P5.5 Compensatory Effect Between Aortic Stiffening and Remodelling During Ageing

Guala¹,

Camporeale²,

Ridolfi³

2015

ARTRES

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The arterial tree exhibits a complex spatio-temporal wave pattern, whose healthy behaviour depends on a subtle balance between mechanical and geometrical properties. Several clinical studies demonstrated that such a balance progressively breaks down during ageing, when the aorta stiffens and remodels by increasing its diameter. These two degenerative processes however, have different impacts on the arterial wave pattern. They both tend to compensate for each other, thus reducing the detrimental effect they would have had if they had arisen individually. This remarkable compensatory mechanism is investigated by a validated multi-scale model, with the aim to elucidate how aortic stiffening and remodelling quantitatively impact the complex interplay between forward and reflected backward waves in the arterial network. We focus on the aorta and on the pressure at the ventricular-aortic interface, which epidemiological studies demonstrate to play a key role in cardiovascular diseases.

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Section: Resultssupporting

confidence: 62%

P5.5 Compensatory Effect Between Aortic Stiffening and Remodelling During Ageing

Guala¹,

Camporeale²,

Ridolfi³

2015

ARTRES

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show abstract

“…The similar growth of proximal and distal sections entails a reduction of pulse pressure amplification with age, as found in several clinical studies [ 22 , 24 , 31 , 45 – 47 ]. Moreover, the increase of characteristic impedance along the aorta is dampened with age [ 48 ]: from 20 to 80 years of age, abdominal values of Z C change from being 8 to 5 times the characteristic impedance at the aortic root and, in particular, in the thoracic aorta the increase reduces from +150% to +80% in the same age range (see panel 3 d ). It follows that the spatial gradient of systolic pressure upstream the thoracic aorta is reduced, contributing (from upstream) to smooth away the peak.…”

Section: Resultsmentioning

confidence: 99%

Compensatory Effect between Aortic Stiffening and Remodelling during Ageing

2015

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“…abdominal aortic stiffness with aging and the mechanisms involved 6–8, 17–20 , despite the clinical importance of this topic for renal perfusion or for abdominal aortic aneurysm, which exceeds thoracic in frequency 21 . There is even relatively little known about regional aortic stiffness and its mechanisms in the absence of aging 17–19 . The present investigation addressed these topics and the results were significant in two major areas; 1) the mechanisms of aortic stiffness that differ with aging, and 2) the differences in aortic stiffness and its mechanisms in the thoracic vs. abdominal aorta.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly some studies even showed an increase in elastin 27, 31 , which should act to decrease aortic stiffness. As noted above, fewer studies have examined both thoracic and abdominal aortic stiffness with aging, in vivo 6–8, 17–20 . Although isolated in vitro studies have found that abdominal stiffness is increased more with aging 32 , most prior studies, in vivo, found that increases in thoracic aortic stiffness with aging were greater than, or similar to that of abdominal aortic stiffness 6–8, 17–20 which is the reverse of our data.…”

Section: Discussionmentioning

confidence: 99%

“…As noted above, fewer studies have examined both thoracic and abdominal aortic stiffness with aging, in vivo 6–8, 17–20 . Although isolated in vitro studies have found that abdominal stiffness is increased more with aging 32 , most prior studies, in vivo, found that increases in thoracic aortic stiffness with aging were greater than, or similar to that of abdominal aortic stiffness 6–8, 17–20 which is the reverse of our data. Interestingly, hypertension without aging, an important disease associated with increased aortic stiffness, has been shown to exhibit greater abdominal than thoracic aortic stiffness 33, 34 .…”

Section: Discussionmentioning

confidence: 99%

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Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness With Aging in Primates

Zhang

Zhao

Vatner

et al. 2016

ATVB

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Objective Increased vascular stiffness is central to the pathophysiology of aging, hypertension, diabetes and atherosclerosis. However, relatively few studies have examined vascular stiffness in both the thoracic and abdominal aorta with aging, despite major differences in anatomy, embryological origin and relation to aortic aneurysm. Approach and Results The two other unique features of this study were 1) to study young (9±1 years) and old (26±1 years) male monkeys, and 2) to study direct and continuous measurements of aortic pressure and thoracic and abdominal aortic diameters in conscious monkeys. As expected, aortic stiffness, β, was increased p<0.05, 2–3 fold, in old vs. young thoracic aorta, and augmented further with superimposition of acute hypertension with phenylephrine. Surprisingly, stiffness was not greater in old thoracic aorta than young abdominal aorta. These results can be explained in part by the collagen/elastin ratio, but more importantly, by disarray of collagen and elastin, which correlated best with vascular stiffness. However, vascular smooth muscle cell stiffness, was not different in thoracic vs. abdominal aorta in either young or old monkeys. Conclusions Thus, aortic stiffness increases with aging as expected, but the most severe increases in aortic stiffness observed in the abdominal aorta is novel, where values in young monkeys equaled, or even exceeded, values of thoracic aortic stiffness in old monkeys. These results can be explained by alterations in collagen/elastin ratio, but even more importantly by collagen and elastin disarray.

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MR pulse wave velocity increases with age faster in the thoracic aorta than in the abdominal aorta

Abstract: The thoracic aorta is less stiff than the abdominal aorta in young and middle-aged subjects, and stiffens more rapidly with age than the abdominal aorta, resulting in a stiffer thoracic than abdominal aorta at older age.

Cited by 26 publications

References 42 publications

P5.5 Compensatory Effect Between Aortic Stiffening and Remodelling During Ageing

P5.5 Compensatory Effect Between Aortic Stiffening and Remodelling During Ageing

Compensatory Effect between Aortic Stiffening and Remodelling during Ageing

Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness With Aging in Primates

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