MR Renography Using a Dynamic Gradient-Echo Sequence and Low-Dose Gadopentetate Dimeglumine as an Alternative to Radionuclide Renography

Teh, Hui Seong; Ang, Ee Sin; Wong, W C; Tan, Say Beng; Tan, Audrey; Chng, Soke Miang; Lin, M. B. K.; Goh, Jeffery Seow Kuang

doi:10.2214/ajr.181.2.1810441

Cited by 57 publications

(29 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A comparison of MRR and RR concentration-time curves confirmed previously reported differences in their respective time-to-peak values (2,24). Measurements of plasma clearance (25) and plasma concentrations of 99m Tc-DTPA and Gd-DTPA in vivo and in vitro (4,26,27), which led to the conclusions about the similarity of the pharmacokinetics of the two contrast agents, do not show such differences.…”

Section: Discussionsupporting

confidence: 84%

Quantitative determination of Gd‐DTPA concentration in T₁‐weighted MR renography studies

Bokacheva

Rusinek

Chen

et al. 2007

Magnetic Resonance in Med

View full text Add to dashboard Cite

A method for calculating contrast agent concentration from MR signal intensity (SI) was developed and validated for T 1 -weighted MR renography (MRR) studies. This method is based on reference measurements of SI and relaxation time T 1 in a Gd-DTPA-doped water phantom. The same form of SI vs. T 1 dependence was observed in human tissues. Contrast concentrations calculated by the proposed method showed no bias between 0 and 1 mM, and agreed better with the reference values derived from direct T 1 measurements than the concentrations calculated using the relative signal method. Phantombased conversion was used to determine the contrast concentrations in kidney tissues of nine patients who underwent dynamic Gd-DTPA-enhanced 3D MRR at 1.5T and 99m Tc-DTPA radionuclide renography (RR). The concentrations of both contrast agents were found to be close in magnitude and showed similar uptake and washout behavior. Quantitative determination of in vivo contrast agent concentration is required in many MR studies that involve perfusion, tracer kinetics, and tissue permeability. The main difficulty of making such estimates arises from the nonlinearity of the MR signal intensity (SI) with the concentration. Additional challenges emerge from the dependence of the concentration on precontrast relaxation times T 1 and T 2 and other difficult-to-control factors, such as flow and respiratory motion.Several methods have been developed for estimating the contrast agent concentration. Most commonly, relative SI change values ⌬S ϭ ͑S Ϫ S 0 ͒/S 0 , where S 0 and S are the pre-and postcontrast SI, are scaled by a constant k to approximate the concentration c ⌬S (1):[1]Alternatively, the acquisition may be designed so that the SI is approximately linear with gadolinium (Gd) concentration over a clinically relevant range (2,3). This method is restrictive and may result in incorrect concentration estimates, especially in regions with high contrast concentrations (e.g., the kidneys). Another approach is to use known sequence parameters and an analytical calibration relationship between SI and T 1 values, which is available for some sequences. However, the validity of some nominal parameters, such as the effective flip angle, has been shown to be problematic (4). Recently several groups have developed a method for calculating the concentration of gadopentetate dimeglumine (Gd-DTPA) from the MR SI based on phantom measurements of signal enhancement over a range of T 1 values (5,6). This method is free from assumptions of linearity between SI and concentration, and may be applied to any pulse sequence. It has the potential to be more accurate than the linear approximation or the analytical calibration methods described above.In this study we demonstrate that the phantom-based method is free from bias for Gd concentrations between 0 and 1 mM. We apply this method to the analysis of the dynamic, Gd-enhanced 3D MR renography (MRR). We compare the results with those obtained using the relative SI change conversion method. In addition, we compare G...

show abstract

Section: Discussionsupporting

confidence: 84%

Quantitative determination of Gd‐DTPA concentration in T₁‐weighted MR renography studies

Bokacheva

Rusinek

Chen

et al. 2007

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…A high correlation (r ϭ 0.97, P Ͻ 0.001) was reported for F% estimates by MR renography compared with radionuclide renography (145). Given the importance of renal artery stenosis in the diagnosis of renal vascular disease, it is important to consider other techniques with potential predictive value.…”

Section: K(t)] Is Given Bymentioning

confidence: 96%

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Prasad

2006

American Journal of Physiology-Renal Physiology

106

View full text Add to dashboard Cite

show abstract

“…[3][4][5][6][7] One disadvantage of these conventional gradient-echo sequences regarding applications in young children is, however, the relatively long acquisition time of approximately 5-15 s resulting in breathing artefacts. In this study, we evaluate a protocol applying a singleshot TurboFLASH sequence with an acquisition time of only 0.5 s, which can be combined with a navigator-triggering technique providing images at virtually identical diaphragm positions.…”

Section: Advances In Knowledgementioning

confidence: 99%

“…Typically, a vascular, parenchymal and excretory phase can be distinguished in the time-intensity curves of healthy kidneys. [3][4][5][6][7] A short vascular phase with a transitory high-signal increase for several seconds immediately after the injection of the Gd-DTPA bolus is followed by a more prolonged linear signal intensity increase over approximately 1-2 min in the parenchymal phase, which corresponds to the contrast medium uptake into the glomeruli. The slope of the signal increase is directly proportional to the filtration capacity per tissue volume.…”

Section: Dynamic Mr Nephrographymentioning

confidence: 99%

Dynamic MR urography in children with uropathic disease with a combined 2D and 3D acquisition protocol—comparison with MAG3 scintigraphy

Boss¹,

Martirosian²,

Fuchs³

et al. 2014

The British Journal of Radiology

View full text Add to dashboard Cite

Objective: The aim of this study was to evaluate combined two-dimensional (2D) and three-dimensional (3D) dynamic MR urography with respiratory compensation in children with anomalies of the genitourinary tract, allowing for computation of split renal function and assessment of urinary tract obstruction. Methods: Dynamic MR urography was performed in 53 children (3 months-16 years of age) with anomalies of the urinary tract. A protocol for dynamic MR urography and nephrography was implemented at 1.5 T using a navigator-triggered 2D TurboFLASH sequence. Split renal function and contrast-medium excretion were assessed after the bolus injection of 0.05 mmol kg 21 body weight of gadolinium dimeglumine. In the excretory phase, a 3D gradientecho data set with high spatial resolution was acquired. In all patients, mercaptoacetyltriglycine (MAG3) scintigraphy was obtained as a reference standard.Results: In all children, dynamic MR nephrography and urography could be performed with excellent compensation of breathing artefacts providing region of interest analysis in nearly identical kidney positions. The assessment of contrastmedium excretion into the ureter allowed for discrimination of functional from non-functional stenosis. Split renal function assessed by MRI showed an excellent agreement with the MAG3 reference standard with a correlation coefficient r 5 0.95. Additionally recorded 3D data sets offered good depiction of anatomical anomalies in all patients. Conclusion:The proposed protocol provides a robust technique for assessment of ureteral obstruction and split renal function with compensation of breathing artefacts, short post-processing time and excellent 3D spatial resolution. Advances in knowledge: The combined protocol of 2D and 3D MR urography is an efficient technique for assessment of renal morphology and function.

show abstract

MR Renography Using a Dynamic Gradient-Echo Sequence and Low-Dose Gadopentetate Dimeglumine as an Alternative to Radionuclide Renography

Cited by 57 publications

References 27 publications

Quantitative determination of Gd‐DTPA concentration in T₁‐weighted MR renography studies

Quantitative determination of Gd‐DTPA concentration in T₁‐weighted MR renography studies

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Dynamic MR urography in children with uropathic disease with a combined 2D and 3D acquisition protocol—comparison with MAG3 scintigraphy

Contact Info

Product

Resources

About

MR Renography Using a Dynamic Gradient-Echo Sequence and Low-Dose Gadopentetate Dimeglumine as an Alternative to Radionuclide Renography

Cited by 57 publications

References 27 publications

Quantitative determination of Gd‐DTPA concentration in T1‐weighted MR renography studies

Quantitative determination of Gd‐DTPA concentration in T1‐weighted MR renography studies

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Dynamic MR urography in children with uropathic disease with a combined 2D and 3D acquisition protocol—comparison with MAG3 scintigraphy

Contact Info

Product

Resources

About

Quantitative determination of Gd‐DTPA concentration in T₁‐weighted MR renography studies

Quantitative determination of Gd‐DTPA concentration in T₁‐weighted MR renography studies