MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients

Hájek, Milan; Dezortová, Monika; Wagnerová, Dita; Škoch, Antonín; Voska, Luděk; Hejlová, Irena; Trunečka, Pavel

doi:10.1007/s10334-011-0264-9

Cited by 28 publications

(35 citation statements)

References 26 publications

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“…Nevertheless, liver fat is not equally distributed within liver and different "within liver" variability has been reported. Hájek et al [14] showed that HFF obtained in three different positions varied by 20% in a group of 77 liver-transplant recipients. Van Werven et al [12] reported regional differences in HFF up to 3.5% and CV=14% in the study of 12 subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Correction for T1 relaxation can be avoided by long TR. A number of studies [9,12,14,[19][20][21] used average T2 values to correct for all patients.…”

Section: Discussionmentioning

confidence: 99%

“…For 3T the following average values have been reported: T2 of water = 27 ms (range 12.4 ms -54.3 ms) and T2 of fat = 61 ms (range 28 ms -82.2 ms) (23); T2 of water range: 12.4 ms -54.3 ms, and T2 of fat range 49 ms -60 ms [14] ; T2 of water = 28 ms (range 22 ms -42 ms) and T2 of fat = 64 ms (range 36 ms -99 ms) [7] . These values for 3T are in line with the results obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Correlation between MRI and histology makes it possible to identify the steatosis grade based on 1H MRS results by linear dependency or by calibration graph [13,14,28] . d'Assignies et al [13] found average HFF= 47.5±19.6 % measured by visual histology and average HFF=18.1±9 % measured by 1H MRS in 20 steatosis patients.…”

Section: Discussionmentioning

confidence: 99%

“…"Within liver" variability of HFF has been studied in groups of adults ranging from 6 to 77 subjects [11][12][13][14] . The aim of the present study was to examine the variability of the HFF in a large group of overweight and obese children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

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Regional differences in hepatic fat fractions in over- weight children and adolescents observed by 3T 1H-MR spectroscopy

Chabanova

Bille²,

Thisted³

et al. 2012

JBGC

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Background: Proton MR Spectroscopy ( 1 H MRS) can be used to measure hepatic fat fractions (HFF) in liver cells for assessment of non-alcoholic fatty liver disease (NAFLD). The measurement is typically performed in a single volume. For correct diagnosis it is important to know variability of HFF within liver. The purpose of this study was to investigate regional differences in HFF in a large group of overweight and obese children and adolescents using 1H MRS at 3T. Methods:The study included 175 consecutive children and adolescents from 7 to 18 years old with a body mass index above the 97th percentile according to age and gender.1 H MRS was performed at 3.0T using a point resolved spectroscopy sequence in two 11mmx11mmx11mm volumes positioned in different parts of the right liver lobe.Results: Up to 12% difference in HFF between the two volumes was observed: the regional differences in HFF are below 1% for patients with HFF under 3%; patients with HFF between 3% and 20% have regional differences in HFF up to 5%; patients with HFF over 20% have regional differences in HFF up to 12%.Conclusions: 1H MRS diagnosis and severity assessment of NAFLD in overweight and obese children and adolescents should take up to 12% regional differences in hepatic fat fractions into account.

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Section: Discussionmentioning

confidence: 99%

“…Correction for T1 relaxation can be avoided by long TR. A number of studies [9,12,14,[19][20][21] used average T2 values to correct for all patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regional differences in hepatic fat fractions in over- weight children and adolescents observed by 3T 1H-MR spectroscopy

Chabanova

Bille²,

Thisted³

et al. 2012

JBGC

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Effect of Omega‐3 Polyunsaturated Fatty Acids on Lipid Metabolism in Patients With Metabolic Syndrome and NAFLD

Šmíd¹,

Dvořák²,

Šedivý³

et al. 2022

Hepatol Commun

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. n‐3 polyunsaturated fatty acids (n‐3‐PUFAs) have been reported to ameliorate the progression of NAFLD in experimental studies; however, clinical trials have yielded contradictory results. The aim of our study was to assess the effects of n‐3‐PUFA administration on lipid metabolism and the progression of NAFLD in patients with metabolic syndrome. Sixty patients with metabolic syndrome and NAFLD were randomized in a double‐blind placebo‐controlled trial (3.6 g/day n‐3‐PUFA vs. placebo). During the 1‐year follow‐up, the patients underwent periodic clinical and laboratory examinations, liver stiffness measurements, magnetic resonance spectroscopy of the liver, and plasma lipidomic analyses. After 12 months of n‐3‐PUFA administration, a significant decrease in serum GGT activity was recorded compared with the placebo group (2.03 ± 2.8 vs. 1.43 ± 1.6; P < 0.05). Although no significant changes in anthropometric parameters were recorded, a significant correlation between the reduction of liver fat after 12 months of treatment—and weight reduction—was observed; furthermore, this effect was clearly potentiated by n‐3‐PUFA treatment (P < 0.005). In addition, n‐3‐PUFA treatment resulted in substantial changes in the plasma lipidome, with n‐3‐PUFA‐enriched triacylglycerols and phospholipids being the most expressed lipid signatures. Conclusion: Twelve months of n‐3‐PUFA treatment of patients with NAFLD patients was associated with a significant decrease in GGT activity, the liver fat reduction in those who reduced their weight, and beneficial changes in the plasma lipid profile.

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In vivo relaxation behavior of liver compounds at 7 tesla, measured by single‐voxel proton MR spectroscopy

Gajdošík

Chmelík

Just-Kukurova

et al. 2013

Magnetic Resonance Imaging

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MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients

Cited by 28 publications

References 26 publications

Regional differences in hepatic fat fractions in over- weight children and adolescents observed by 3T 1H-MR spectroscopy

Regional differences in hepatic fat fractions in over- weight children and adolescents observed by 3T 1H-MR spectroscopy

Effect of Omega‐3 Polyunsaturated Fatty Acids on Lipid Metabolism in Patients With Metabolic Syndrome and NAFLD

In vivo relaxation behavior of liver compounds at 7 tesla, measured by single‐voxel proton MR spectroscopy

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