MR spectroscopy of liver in overweight children and adolescents: Investigation of 1H T2 relaxation times at 3T

Regional differences in hepatic fat fractions in over- weight children and adolescents observed by 3T 1H-MR spectroscopy

“…An up to 12% difference in HFF between the two volumes was observed: the regional differences in HFF are below 1% for patients with HFF under 3%; patients with HFF between 3% and 20% have regional differences in HFF up to 5%; patients with HFF over 20% have regional differences in HFF up to 12%. HFF variation between the two volumes is shown in Figure 2 and in (a) (b) HFF obtained at TE=75 ms is overestimated due to T2 relaxation effects [7] . Figure 4 shows correlation between HFF compensated for T2 relaxation (at TE=0 ms) and HFF measured at TE=75ms.…”

“…For 3T the following average values have been reported: T2 of water = 27 ms (range 12.4 ms -54.3 ms) and T2 of fat = 61 ms (range 28 ms -82.2 ms) (23); T2 of water range: 12.4 ms -54.3 ms, and T2 of fat range 49 ms -60 ms [14] ; T2 of water = 28 ms (range 22 ms -42 ms) and T2 of fat = 64 ms (range 36 ms -99 ms) [7] . These values for 3T are in line with the results obtained in the present study.…”

“…HFF was calculated for the two different volumes at TE=75 ms. Water and fat T2 relaxation times and HFF corrected for T2 relaxation effects (HFF at TE=0 ms) were calculated when the fat peak was sufficiently large (HFF>10% at TE=75 ms) in one of the volumes using an exponential least-square fitting algorithm to the peak areas with the series TE as described earlier [7] . TR of 4 s was considered sufficiently long to avoid influence of T1 relaxation in the post-processing calculations.…”

“…Proton MRS (1H MRS) can measure the triglyceride content in liver cells directly and quantitatively analyze the fat fraction (HFF) in the liver [7,8] . 1H MRS is more accurate in the detection of fatty liver than computed tomography (CT) and exhibit higher sensitivity in the detection of liver fat content than conventional MR imaging and ultrasound investigations [9,10] .…”

In vivo and ex vivo measurements: noninvasive assessment of alcoholic fatty liver using 1H-MR spectroscopy

“…In a series of studies, the following average T2 values were calculated by the 3.0 T MRI system: T2 water, 27 ms (range, 12.4-54.3 ms) and T2 fat, 61 ms (range, 28-82.2 ms) (30); T2 water, 12.4-54.3 ms and T2 fat, 49-60 ms (26); T2 water, 28 ms (range, 22-42 ms) and T2 fat, 64 ms (range, 36-99 ms) (31). These values are consistent with the results obtained in the present study.…”