MR-Tomographie bei lymphatischen und leukämischen Knochenmarkinfiltrationen

Abstract

MR is the only noninvasive procedure that can demonstrate changes in the medullary space. If it is combined with bone marrow scintigraphy and conventional x-ray film diagnostics, it can yield a comprehensive diagnosis of bone marrow infiltrations in the regions of the pelvis, thighs and lumbar vertebral column in leukaemia or malignant lymphomas. The T1 relaxation times of the malignant infiltrations are enhanced compared with normal fatty marrow. MR tomography of the bone marrow is particularly suitable for determining the therapy or follow-up control of a malignant systemic disease.

Recent advances in bone marrow scanning

“…7. In addition, MRI demonstrated diffuse infiltration in expanded, phagocytic bone marrow (Hotze et al 1989;Widding et al 1989;Dewes et al 1987). In addition, MRI demonstrated diffuse infiltration in expanded, phagocytic bone marrow (Hotze et al 1989;Widding et al 1989;Dewes et al 1987).…”

“…reticulum cells) may provide the necessary microenvironment for homing of malignant cells. Diffusely reduced TcNCAA bone marrow uptake and multiple larger marrow defects in advanced multiple myeloma rect evidence of spread of "infiltrated tissue" (Dewes et al 1987). Sensitivity, specificity, PPV and NPV of radiocolloid marrow scanning in malignant lymphomas (according to Linden et al 1989, modified) 8.…”

MR-Tomographie der Unterschenkel bei Kindern mit Erkrankungen des hämatopoetischen Systems

“…Auch eine Verwechslung von pathologischen Arealen mit verbliebenen Blutbildungsherden ist in den Unterschenkeln nahezu ausgeschlossen. Aus diesen Gründen sehen wir in der Wahl der Untersuchungsregion die Ursachen, weshalb der Einsatz T2-betonter Sequenzen bei unseren Patienten im Gegensatz zu jenen anderer Autoren (5,8,27) terschied war jedoch subjektiv so eindeutig ersichtlich, daß auf eine T lund T2-Wertmessung verzichtet werden konnte. Unsere Deutung stimmt auch hier mit der Klinik gut überein, denn das M R Bild einer Siderose zeigte sich nur bei Patienten unter oder nach Transfusionstherapie.…”

Magnetic resonance imaging of the bone marrow in hematological malignancies

“…7) [21, 29, 72,73]. In a series of 80 adult patients with acute leukemia, signal intensity of the vertebral bone marrow was lower than that of discs in 73 The appearance of the appendicular skeleton marrow in patients with acute leukemia is more variable [18, 20, 23, 85±87].…”

“…7) [21, 29, 72,73]. In a series of 80 adult patients with acute leukemia, signal intensity of the vertebral bone marrow was lower than that of discs in 73 The appearance of the appendicular skeleton marrow in patients with acute leukemia is more variable [18, 20, 23, 85±87]. In patients with myeloproliferative disorders including chronic myelogeneous leukemia and polycythemia vera, the extent of marrow infiltration in the appendicular skeleton correlates with the spleen size, which is a parameter indicative of disease extent [87,88].…”