MR Tracking of Iron-labeled Glass Radioembolization Microspheres during Transcatheter Delivery to Rabbit VX2 Liver Tumors: Feasibility Study

Abstract

Microsphere tracking during radioembolization may permit real-time verification of delivery and detection of extrahepatic shunting.

SPIO-labeled Yttrium Microspheres for MR Imaging Quantification of Transcatheter Intrahepatic Delivery in a Rodent Model

“…Microspheres containing 2%, 5%, 10%, and 20% SPIO (percentage by mass) with a diameter distribution from 20 to 40 µm were used for this study (13).…”

“…Labeling 90 Y microspheres with superparamagnetic iron oxide (SPIO) offers the potential to use MR imaging to visualize in vivo biodistributions (13). Susceptibility differences between SPIO particles and surrounding tissues lead to local magnetic field gradients with proportional signal losses through R2* relaxation mechanisms.…”

“…Susceptibility differences between SPIO particles and surrounding tissues lead to local magnetic field gradients with proportional signal losses through R2* relaxation mechanisms. Feasibility studies demonstrated that SPIO-labeled radioembolization microspheres permit qualitative visualization of microsphere biodistribution following transcatheter delivery to the liver (13). However, the strong susceptibility effects of SPIO can rapidly reduce the MR signal below the noise floor, thus complicating quantification procedures.…”

Iron Oxide Nanoparticles Imaging Tracking by MR Advanced Techniques: Dual-Contrast Approaches

“…Iron-labeled radioembolization microspheres were visualized for in vivo tracking during trans-catheter delivery to VX2 liver tumors in a rabbit model (Gupta, 2008). The study was performed for real-time observation of microsphere delivery with dual-contrast techniques.…”

Microspheres for radioembolization of liver malignancies

“…Gupta and colleagues reported on glass microspheres containing Fe 3 O 4 proposed as surrogates for the glass 90 Y-microspheres [8].…”