2023
DOI: 10.1101/2023.03.15.532782
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MRE11A: a novel negative regulator of human DNA mismatch repair

Abstract: DNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors. Although well characterized, MMR factors remain to be identified. As a 3'-5' exonuclease and endonuclease, meiotic recombination 11 homolog A (MRE11A) is implicated in multiple DNA repair pathways. However, the role of MRE11A in MMR is unclear. Here, we show that MRE11A deficiency increased the sensitivity of HeLa cells to N-methyl-N' nitro-N nitrosoguanidine (MNNG) treatment, implying a potential role of MRE11 in MMR… Show more

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