2002
DOI: 10.1074/jbc.m203839200
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MRG15, a Novel Chromodomain Protein, Is Present in Two Distinct Multiprotein Complexes Involved in Transcriptional Activation

Abstract: MRG15 is a novel chromodomain protein that is a member of a family of genes related to MORF4. MORF4 (mortality factor on chromosome 4) induces senescence in a subset of human tumor cell lines. Our previous results indicated that MRG15 (MORF-related gene on chromosome 15) could derepress the B-myb promoter by association with Rb. In this study, sucrose gradient analysis demonstrated that MRG15 was present in two distinct nuclear protein complexes, MAF1 (MRG15-associated factor 1) and MAF2. Rb was associated wit… Show more

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Cited by 78 publications
(93 citation statements)
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“…2C) and that the unique N-terminal domain of MRGX was not required for function in either cell type. These results were strikingly different from those obtained with MRG15, because the unique N-terminal CHR in MRG15 was essential for B-myb promoter activation (17). It was also unexpected that the same regions of the MRGX protein were involved in activating and repressing the promoter in the different cell types.…”
Section: Effect Of Wild-type and Various Mutant Mrgx Proteins On The contrasting
confidence: 57%
See 3 more Smart Citations
“…2C) and that the unique N-terminal domain of MRGX was not required for function in either cell type. These results were strikingly different from those obtained with MRG15, because the unique N-terminal CHR in MRG15 was essential for B-myb promoter activation (17). It was also unexpected that the same regions of the MRGX protein were involved in activating and repressing the promoter in the different cell types.…”
Section: Effect Of Wild-type and Various Mutant Mrgx Proteins On The contrasting
confidence: 57%
“…MRG15-associated factor 1 involved MRG15, Rb, and PAM14, and MRG15-associated factor 2 contained MRG15 and the histone acetyltransferase hMOF (17,21). When MRGX was analyzed on these gradients, it was found to be present in multiple fractions but not those involving hMOF (data not shown).…”
Section: Effect Of Wild-type and Various Mutant Mrgx Proteins On The mentioning
confidence: 92%
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“…The chromodomain-containing MRG15 and MRGX proteins share significant sequence similarity (E-value e Ϫ106 ) and are members of a larger family that includes the MORF4 protein, which was originally identified as a protein capable of inducing a senescent phenotype in a subset of immortal human cell lines (20). Members of the MRG protein family have been implicated in both transcriptional activation (21,22) and repression (23). The human MRG15 and MRGX proteins share significant sequence similarity with the S. cerevisiae chromodomain-containing protein Eaf3 (E-values 7e…”
Section: Multiprotein Mammalian Trrap⁄tip60-containing Hat Complex 42734mentioning
confidence: 99%