MRI Acquisition and Analysis Protocol for In Vivo Intraorbital Optic Nerve Segmentation at 3T

Yiannakas, Marios C.; Toosy, Ahmed; Raftopoulos, Rhian; Kapoor, Raj; Miller, David H.; Wheeler‐Kingshott, Claudia A. M.

doi:10.1167/iovs.13-12357

Cited by 20 publications

(23 citation statements)

References 21 publications

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“…92 These advanced techniques can assist in the early detection of clinical impairment, and enable quantitative estimation of the presence and extent of damage to the optic nerve. 93,94 These measures have all been proposed as markers of irreversible tissue damage and disease progression, and as predictors of clinical recovery.…”

Section: Research Protocolmentioning

confidence: 99%

The investigation of acute optic neuritis: a review and proposed protocol

et al. 2014

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| Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.

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Section: Research Protocolmentioning

confidence: 99%

The investigation of acute optic neuritis: a review and proposed protocol

et al. 2014

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“…MRI has recently been shown to be accurate at measuring the ON and the CSF sheath using manual observers [12]. Recent efforts have also attempted to automatically segment the ON in MRI but did not segment the sheath or apply to their tool to diseased patients [13]. Recently, we have proposed multi-atlas segmentation pipelines for both CT [14] and MRI[15].…”

Section: Introductionmentioning

confidence: 99%

Constructing a statistical atlas of the radii of the optic nerve and cerebrospinal fluid sheath in young healthy adults

et al. 2015

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Optic neuritis is a sudden inflammation of the optic nerve (ON) and is marked by pain on eye movement, and visual symptoms such as a decrease in visual acuity, color vision, contrast and visual field defects. The ON is closely linked with multiple sclerosis (MS) and patients have a 50% chance of developing MS within 15 years. Recent advances in multi-atlas segmentation methods have omitted volumetric assessment. In the past, measuring the size of the ON has been done by hand. We utilize a new method of automatically segmenting the ON to measure the radii of both the ON and surrounding cerebrospinal fluid (CSF) sheath to develop a normative distribution of healthy young adults. We examine this distribution for any trends and find that ON and CSF sheath radii do not vary between 20–35 years of age and between sexes. We evaluate how six patients suffering from optic neuropathy compare to this distribution of controls. We find that of these six patients, five of them qualitatively differ from the normative distribution which suggests this technique could be used in the future to distinguish between optic neuritis patients and healthy controls.

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“…; Yiannakas et al. ). Several publications have used MRI to evaluate CSFP by measuring the size of the optic nerve sheath or the optic nerve subarachnoid space (Geeraerts et al.…”

Section: Introductionmentioning

confidence: 97%