MRI and bone scintigraphy for breast cancer bone metastase: a meta-analysis

Rong, Yue; Ren, Hong; Ding, Xiaobo

doi:10.1515/med-2019-0029

Cited by 5 publications

(6 citation statements)

References 16 publications

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“…According to their findings, the cost of identifying one instance of recurring disease would total $140,400. Therefore, utilizing bone scintigraphy as a screening method for detecting recurring disease in early-stage breast cancer patients results in significant healthcare costs [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Bone scans (BS) employ technetium-99m-labeled diphosphonate to detect developing bone formation, advantageous in the early detection of bone metastasis linked to osteolytic metastases [ 4 ]. Recent retrospective investigations have cast doubt on the clinical efficacy of BS as a staging technique in breast cancer [ 5 , 6 ]. Previous studies documented favorable outcomes in asymptomatic breast cancer cases, but subsequent investigations failed to replicate these significant results [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recent retrospective investigations have cast doubt on the clinical efficacy of BS as a staging technique in breast cancer [ 5 , 6 ]. Previous studies documented favorable outcomes in asymptomatic breast cancer cases, but subsequent investigations failed to replicate these significant results [ 5 , 6 ]. Particularly, when patients have undergone staging computed tomography (CT) scans, questions arise regarding cost-effectiveness and utility [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Bone Scans in Preoperative Investigations of Breast Cancer Cases

Mansy,

Elsenosy,

Hassan

et al. 2023

Cureus

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Background: Breast cancer constitutes about 28% of all new cancer diagnoses in women, making it the most frequently diagnosed cancer among them. Our objective was to assess the role of bone scans (BS) in preoperative investigations of breast cancer. Methods: This study involved 105 patients with varying stages of breast cancer, ranging from T1 to T4. We categorized them into three groups: group 1 comprised 40 women with breast cancer who underwent retrospective BS, group 2 included 30 patients with breast cancer who prospectively did not require BS for all cases, and group 3 consisted of 35 women retrospectively diagnosed with breast cancer who did not necessitate BS for all cases. The diagnosis of bone metastasis was confirmed upon obtaining a positive result through bone scintigraphy, subsequently affirmed by another imaging technique such as CT, X-ray, or MRI. Results: The hospital costs were significantly lower in groups 2 and 3 compared to that of group 1, indicating that performing a BS for every case is unnecessary. It was observed that the time taken for surgery was notably shorter in groups 2 and 3 compared to that of group 1. BS in cases classified as M stage were deemed both costly and time-consuming. Conclusions: Routine BS are not cost-effective and represent an unnecessary investment of time. They should not be deemed mandatory as preoperative investigations in breast cancer cases. Instead, they should be considered in conjunction with MRI, particularly in cases of T4 breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bone Scans in Preoperative Investigations of Breast Cancer Cases

Mansy,

Elsenosy,

Hassan

et al. 2023

Cureus

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“…Due to major advances in modern tomographic imaging, the current trend is toward computer tomography (CT) and magnetic resonance imaging (MRI) based structural rigidity analysis to assess osseous stability in patients with metastatic bone disease [29–32]. Positron emission tomography-computed tomography (PET-CT) and MRI are reported to have the highest sensitivity and specificity for detecting bone metastases.…”

Section: Metastatic Bone Diseasementioning

confidence: 99%

“…In addition, in certain cases orthosis treatment may help to stabilize bone structures in multiple myeloma. Assessment of osseous stability follows the same rules as for patients suffering from metastatic bone disease [29–32, 36, 37]. Pain in patients with multiple myeloma is also treated in an interdisciplinary and multimodal manner using medication according to the World Health Organization, bisphosphonates and physical medical modalities (e.g.…”

Section: Multiple Myelomamentioning

confidence: 99%

Typical aspects in the rehabilitation of cancer patients suffering from metastatic bone disease or multiple myeloma

Kéilani

Kainberger

Pataraia

et al. 2019

Wien Klin Wochenschr

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SummaryBackgroundThe aim of this study was to present a practical concept focusing on typical aspects of regular physical activity, exercise and physical modalities for patients suffering from metastatic bone disease or multiple myeloma.MethodsA narrative review of the relevant scientific literature and presentation of clinical experiences.ResultsIn cancer patients with metastatic bone disease or multiple myeloma, pain is treated in an interdisciplinary and multimodal setting by using medication, radiotherapy and physical medical modalities (e.g. transcutaneous electrical nerve stimulation); however, modalities increasing local blood flow, such as ultrasound therapy, thermotherapy, massage, various electrotherapy options, are not performed at the site of the tumor. For physical activity and exercise, a suitable indication of the static and dynamic capacity of the affected skeletal structures is essential. This process includes strategies to maintain and improve mobility and independence. Individually tailored and adapted physical activity and exercise concepts (programs) within a multidisciplinary and interdisciplinary setting (tumor board) are used to manage the condition and bone load-bearing capacity of the patient. Typical clinical features and complications, such as pathological fractures in patients suffering from metastatic bone disease and additionally hypercalcemia, monoclonal gammopathy with bone marrow aplasia and risk of renal failure in patients with multiple myeloma have to be considered when planning supportive strategies and rehabilitation.ConclusionIn order to ensure the safety and effectiveness of regular physical activity, exercise, and physical modalities in patients with metastatic bone disease or multiple myeloma, typical contraindications and considerations should be noted.

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