MRI and MRS predictors of mild cognitive impairment in a population-based sample

Kantarci, Kejal; Weigand, Stephen D.; Przybelski, Scott A.; Preboske, Gregory M.; Pankratz, V. Shane; Vemuri, Prashanthi; Senjem, Matthew L.; Murphy, Matthew; Gunter, Jeffrey L.; Machulda, Mary M.; Ivnik, Robert J.; Roberts, Rosebud O.; Boeve, Bradley F.; Rocca, Walter A.; Knopman, David S.; Petersen, Ronald C.; Jack, Clifford R.

doi:10.1212/wnl.0b013e31829a3329

Cited by 95 publications

(75 citation statements)

References 37 publications

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“…The hippocampus mediates verbal memory [10][11][12] and hippocampal volume is related to risk of aMCI 13 and AD dementia. 14 We tested the hypothesis that the female advantage in verbal memory reflects a form of cognitive reserve by examining sex differences in the relationship between AD-related clinical presentation (verbal memory performance) and neurodegeneration (hippocampal volume/intracranial volume ratio [HpVR]) across and within diagnostic categories (control, aMCI, AD dementia).…”

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confidence: 99%

“…However, hippocampal volumes are a biomarker of imminent cognitive decline and progression from MCI to AD dementia in longitudinal studies. 12,13 This design also limits our test of the cognitive reserve theory because we were unable to measure rates of decline in men vs women. Population-based, longitudinal analyses are needed to more definitively test the theory that the female advantage in verbal memory may serve as a form of cognitive reserve.…”

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confidence: 99%

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Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy

et al. 2016

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Objective: To examine sex differences in the relationship between clinical symptoms related to Alzheimer disease (AD) (verbal memory deficits) and neurodegeneration (hippocampal volume/ intracranial volume ratio [HpVR]) across AD stages. Methods:The sample included 379 healthy participants, 694 participants with amnestic mild cognitive impairment (aMCI), and 235 participants with AD and dementia from the Alzheimer's Disease Neuroimaging Initiative who completed the Rey Auditory Verbal Learning Test (RAVLT). Cross-sectional analyses were conducted using linear regression to examine the interaction between sex and HpVR on RAVLT across and within diagnostic groups adjusting for age, education, and APOE e4 status.Results: Across groups, there were significant sex 3 HpVR interactions for immediate and delayed recall (p , 0.01). Women outperformed men among individuals with moderate to larger HpVR, but not among individuals with smaller HpVR. In diagnosis-stratified analyses, the HpVR 3 sex interaction was significant in the aMCI group, but not in the control or AD dementia groups, for immediate and delayed recall (p , 0.01). Among controls, women outperformed men on both outcomes irrespective of HpVR (p , 0.001). In AD dementia, better RAVLT performance was independently associated with female sex (immediate, p 5 0.04) and larger HpVR (delayed, p 5 0.001). The cognitive reserve theory posits that favorable premorbid factors including higher education and IQ delay the onset of clinical deficits despite Alzheimer disease (AD)-related neurodegeneration because compensatory mechanisms are more readily engaged (e.g., alternate brain networks or cognitive strategies). Conclusion:1-3 The theory predicts that the onset of accelerated cognitive decline is closer in time to AD dementia diagnosis in individuals with greater cognitive reserve; however, after onset, their decline is more rapid because neurodegeneration is more advanced at that point. [4][5][6] Throughout life, women outperform men on verbal memory tasks. [7][8][9] We predict that this female advantage may reflect a sex-specific form of cognitive reserve resulting in a delay in the clinical manifestation of memory impairment until more advanced neurodegeneration overwhelms the female advantage and decline begins. Thereafter, we predict that women decline From the Einstein Aging Study and the

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Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy

et al. 2016

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“…Using MRS to detect changes in the concentrations of the metabolites, the pathological changes of patients with LA can be evaluated. 21 According to a populationbased study, 22 the measurement of MRI and MRS markers can predict progression to MCI and cognitive decline in cognitively normal older adults. 23 Thus MRS is a powerful tool for investigating the pathogenesis and pathological changes of LACI.…”

Section: Magnetic Resonance Imaging Studies Of the Lacimentioning

confidence: 99%

Leukoaraiosis with mild cognitive impairment

Zhao

Zheng

et al. 2015

Neurological Research

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“…The applications of 1 HMRS include early diagnosis, differential diagnosis, and tracking of the pathological process by detecting metabolite changes [5]. Voluminal MRI and quantitative 1 HMRS were complementary in differentiating MCI and predicting cognitive performance in older individuals [6]. Compared with individuals with a single pathology, in patients with multiple brain pathologies including decreased n-acetylaspartate (NAA) levels, the risk of MCI may increase [7].…”

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confidence: 99%

Proton magnetic resonance spectroscopy as a diagnostic biomarker in mild cognitive impairment following stroke in acute phase

Meng

Shi²,

Su³

2016

NeuroReport

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To investigate proton magnetic resonance spectroscopy (HMRS) as a diagnostic biomarker to identify mild cognitive impairment (MCI) following stroke in the acute phase. A total of 72 stroke patients were recruited in the acute phase of stroke from the Department of Neurology, including 36 stroke patients with MCI and 36 stroke patients without MCI. All patients underwent brain MRI/MRS examination on a 3.0 T scanner and a neuropsychological test in the acute phase of stroke. Single-voxel HMRS was performed to obtain hippocampal metabolism intensities and brain infarcts were assessed on MRI. Group difference in metabolite ratios was analyzed using a T-test. Spearman rank correlation was used to study the correlation between metabolite ratios and Montreal Cognitive Assessment scores. The hippocampal n-acetylaspartate/creatine (NAA/Cr) ratio was found to be significantly lower in stroke patients with MCI compared with stroke patients without MCI (P<0.02). However, we found no differences in the metabolite ratios between hippocampus ipsilateral to infarctions and the contralateral side (P>0.05) in stroke patients with MCI. Furthermore, a correlation was found between hippocampal NAA/Cr ratios and Montreal Cognitive Assessment scores in stroke patients with MCI (P<0.01). HMRS could be a biomarker to identify MCI following stroke in the acute phase by capturing neurodegenerative changes.

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MRI and MRS predictors of mild cognitive impairment in a population-based sample

Cited by 95 publications

References 37 publications

Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy

Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy

Leukoaraiosis with mild cognitive impairment

Proton magnetic resonance spectroscopy as a diagnostic biomarker in mild cognitive impairment following stroke in acute phase

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