MRI- and PET-Based Assessment of Radiological and Clinical Factors Associated With Cervical Cancer Response to External Beam Radiation Therapy

Abstract

In the era of MRI-guided external beam radiation therapy (EBRT), complete radiological response (CR) is often seen in cervical cancer (CC) with 4-6 weeks of chemotherapy and EBRT. The clinical and radiological factors associated with this observation were investigated in this study. Materials and methodsOne hundred and twenty-four CC patients treated with concurrent chemotherapy, EBRT, and brachytherapy (BT) from January 2008 to July 2015 were retrospectively screened. Initial primary gross tumor volume (GTV INITIAL ) was estimated after contouring on a planning CT scan registered with pre-EBRT PET and MRI.The maximum standardized uptake value (SUV) of GTV INITIAL from each PET scan report was collected.Spearman's rank correlation coefficient (rho) values were calculated to assess the relationships among age, tumor size, and SUV. Tumor radiological response during EBRT prior to BT was calculated by contouring the final primary gross tumor volume (GTV FINAL ) using MRI obtained prior to BT. CR rates during EBRT were estimated from GTV INITIAL and GTV FINAL and compared by the level of various factors using Fisher's exact test (two-sided). ResultsForty-eight patients met the inclusion criteria of the study with a median age of 50 years. The median GTV INITIAL was 82 cc. The median SUV was 14.9. A significant correlation was seen between SUV and GTV INITIAL with a larger tumor size associated with a higher SUV. CR rates were numerically higher for patients who were aged <50 years, or with >37.5 Gy radiation dose at or before the second MRI, or with GTV INITIAL <100 cc, or with no nodes involved or with stages IB or IIA. ConclusionsOur study identified higher CC primary tumor CR rates during EBRT in younger patients (<50) with smaller tumors (100 cc) without nodal involvements as well as a positive correlation between PET FDG (18Ffluorodeoxyglucose)-SUV and CC primary tumor size.