MRI and <sup>31</sup>
P magnetic resonance spectroscopy hardware for axillary lymph node investigation at 7T

Rivera, Debra; Wijnen, Jannie P.; Kemp, Wybe J. M. van der; Raaijmakers, Alexander J. E.; Luijten, Peter R.; Klomp, Dennis W. J.

doi:10.1002/mrm.25304

Cited by 13 publications

(13 citation statements)

References 46 publications

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“…Polarization transfer techniques transfer the polarization of excited 1 H spins through J-coupling to the 31 P spins, increasing the signal-to-noise ratio and eliminating resonances without 1 H- 31 P coupling, thereby flattening the baseline and significantly increasing the signal-to-noise ratio of PE, PC, GPE and GPC at 1.5T [107], 3T [100] and 7T [106]. Using specialized hardware to adapt high-field 31 P MRS at 7T, it was possible to detect 31 P MR spectra from a small 3-mm diameter lymph node in the axilla [108]. These recent advances in 31 P MRS coil and pulse sequence design will enable the detection of individual PE, PC, GPE and GPC in cancers in the near future.…”

Section: Cancer Detection and Monitoring Response To Treatmentmentioning

confidence: 99%

Choline metabolism-based molecular diagnosis of cancer: an update

Glunde

Penet

Jiang

et al. 2015

Expert Review of Molecular Diagnostics

112

120

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Abnormal choline metabolism continues to be identified in multiple cancers. Molecular causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine kinase-α, phosphatidylcholine-specific phospholipase C and -D and glycerophosphocholine phosphodiesterases, as well as several choline transporters. The net outcome of these enzymatic changes is an increase in phosphocholine and total choline (tCho) and, in some cancers, a relative decrease of glycerophosphocholine. The increased tCho signal detected by 1H magnetic resonance spectroscopy is being evaluated as a diagnostic marker in multiple cancers. Increased expression and activity of choline transporters and choline kinase-α have spurred the development of radiolabeled choline analogs as PET imaging tracers. Both tCho 1H magnetic resonance spectroscopy and choline PET are being investigated to detect response to treatment. Enzymes mediating the abnormal choline metabolism are being explored as targets for cancer therapy. This review highlights recent molecular, therapeutic and clinical advances in choline metabolism in cancer.

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Section: Cancer Detection and Monitoring Response To Treatmentmentioning

confidence: 99%

Choline metabolism-based molecular diagnosis of cancer: an update

Glunde

Penet

Jiang

et al. 2015

Expert Review of Molecular Diagnostics

112

120

View full text Add to dashboard Cite

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“…The tumor size that is possible to investigate with 7 T depends on the location of the tumor. For example, a sub mL volume (<0.1 mL) of signal‐generating tissue with <2 mmol concentrations of PMEs has been detected above the noise floor in healthy axilla lymph nodes . In the breast, a < 2 mL volume tumor was monitored for treatment tracking using 31 P at 7 T .…”

Section: Discussionmentioning

confidence: 99%

Inherently decoupled¹H antennas and³¹P loops for metabolic imaging of liver metastasis at 7 T

et al. 2020

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High field 31P spectroscopy has thus far been limited to diffuse liver disease. Unlike lower field‐strength scanners, there is no body coil in the bore of the 7 T and despite inadequate penetration depth (<10 cm), surface coils are the current state‐of‐the‐art for acquiring anatomical images to support multinuclear studies. We present a system of proton antennas and phosphorus loops for 31P spectroscopy and provide the first ultrahigh‐field phosphorus metabolic imaging of a tumor in the abdomen. Herein we characterize the degree to which antennas are isolated from underlying loops. Next, we evaluate the penetration depth of the two antennas available during multinuclear examinations. Finally, we combine phosphorus spectroscopy (two loops) with parallel transmit imaging (eight antennas) in a patient. The loops and antennas are inherently decoupled (no added circuitry, <0.1% power coupling). The penetration depth of two antennas gives twice that of conventional loops. The liver and full axial slice of the abdomen were imaged with eight transmit/receive antennas using parallel transmit B1‐shimming to overcome image voids. Phosphorus spectroscopy from a liver metastasis resolved individual peaks for phosphocholine and phosphoethenalomine. Proton antennas are inherently decoupled from phosphorus loops. By using two proton antennas it is possible to perform region‐of‐interest image‐based shimming in over 80% of the liver volume, thereby enabling phosphorus spectroscopy of localized disease. Shimming of the full extent of the abdominal cross‐section is feasible using a parallel transmit array of eight antennas. A system architecture capable of supporting eight‐channel parallel transmit and multinuclear spectroscopy is optimal for supporting multiparametric body imaging, including metabolic imaging, for monitoring the response of patients with liver metastases to cancer treatments and for patient risk stratification. In the meantime, the existing infrastructure using two antennas is sufficient for preliminary studies in metabolic imaging of tumors in the liver.

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“…Although the 23 Na solenoids provided good coverage, 1 H coverage was confined primarily to the breast and degraded toward the axillary and chest wall regions. This is a common weakness in 7T 1 H breast MRI, which has been addressed with dedicated hardware . In the case of our design, space constraints for the multiple bilateral coil layers may have accentuated its compressed local field pattern.…”

Section: Discussionmentioning

confidence: 99%

“…This is a common weakness in 7T 1 H breast MRI, 36,39,52,53 which has been addressed with dedicated hardware. 54,55 In the case of our design, space constraints for the multiple bilateral coil layers may have accentuated its compressed local field pattern.…”

Section: Discussionmentioning

confidence: 99%

A dual‐tuned multichannel bilateral RF coil for ¹H/²³Na breast MRI at 7 T

Ianniello

Madelin

Moy

et al. 2019

Magnetic Resonance in Med

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Purpose Sodium MRI has shown promise for monitoring neoadjuvant chemotherapy response in breast cancer. The purpose of this work was to build a dual‐tuned bilateral proton/sodium breast coil for 7T MRI that provides sufficient SNR to enable sodium breast imaging in less than 10 minutes. Methods The proton/sodium coil consists of 2 shielded unilateral units: 1 for each breast. Each unit consists of 3 nested layers: (1) a 3‐loop solenoid for sodium excitation, (2) a 3‐loop solenoid for proton excitation and signal reception, and (3) a 4‐channel receive array for sodium signal reception. Benchmark measurements were performed in phantoms with and without the sodium receive array insert. In vivo images were acquired on a healthy volunteer. Results The sodium receive array boosted 1.5 to 3 times the SNR compared with the solenoid. Proton SNR loss due to residual interaction with the sodium array was less than 10%. The coil enabled sodium imaging in vivo with 2.8‐mm isotropic nominal resolution (~5‐mm real resolution) in 9:36 minutes. Conclusion The coil design that we propose addresses challenges associated with sodium's low SNR from a hardware perspective and offers the opportunity to investigate noninvasively breast tumor metabolism as a function of sodium concentration in patients undergoing neoadjuvant chemotherapy.

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MRI and ³¹ P magnetic resonance spectroscopy hardware for axillary lymph node investigation at 7T

Cited by 13 publications

References 46 publications

Choline metabolism-based molecular diagnosis of cancer: an update

Choline metabolism-based molecular diagnosis of cancer: an update

Inherently decoupled¹H antennas and³¹P loops for metabolic imaging of liver metastasis at 7 T

A dual‐tuned multichannel bilateral RF coil for ¹H/²³Na breast MRI at 7 T

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MRI and 31 P magnetic resonance spectroscopy hardware for axillary lymph node investigation at 7T

Cited by 13 publications

References 46 publications

Choline metabolism-based molecular diagnosis of cancer: an update

Choline metabolism-based molecular diagnosis of cancer: an update

Inherently decoupled1H antennas and31P loops for metabolic imaging of liver metastasis at 7 T

A dual‐tuned multichannel bilateral RF coil for 1H/23Na breast MRI at 7 T

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MRI and ³¹ P magnetic resonance spectroscopy hardware for axillary lymph node investigation at 7T

Inherently decoupled¹H antennas and³¹P loops for metabolic imaging of liver metastasis at 7 T

A dual‐tuned multichannel bilateral RF coil for ¹H/²³Na breast MRI at 7 T