MRI and the brain in systemic lupus erythematosus

Graham, Julia; Jan, Wajanat

doi:10.1191/0961203303lu498oa

Cited by 50 publications

(39 citation statements)

References 5 publications

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“…3 Although various neurological manifestations occur in 50-70% of cases of SLE, the brain MRI remains normal. 4 The patient's history of SLE raised this possibility, although clinically the disease appeared quiescent. A low cognitive score for an individual is a poor predictor of the presence of CNS involvement.…”

Section: Discussionmentioning

confidence: 99%

Sporadic Creutzfeldt-Jakob disease: a rare cause of rapid cognitive decline in a patient with systemic lupus erythematosus

Costello

Phadke²,

Shah³

2011

JRCPE

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An immunocompromised patient with non-specific neurological symptoms and signs, along with rapid cognitive decline evolving over three to four weeks, can present a diagnostic challenge. Here we report rapidly progressive dementia in a patient with systemic lupus erythematosus, who was subsequently diagnosed with sporadic Creutzfeldt-Jakob disease (sCJD). This case illustrates the need for prompt investigations to consider an alternative diagnosis where significant history fails to yield an explanation. A diagnosis of sCJD drastically alters the prognosis in a subject with a well-controlled connective tissue disease who is otherwise fit and well.

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Section: Discussionmentioning

confidence: 99%

Sporadic Creutzfeldt-Jakob disease: a rare cause of rapid cognitive decline in a patient with systemic lupus erythematosus

Costello

Phadke²,

Shah³

2011

JRCPE

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“…Characteristic histological changes include proliferations of intimal cells, increased fibrous tissue and mucoid hyperplasia; the lumen may become occluded by fibrin thrombi, and the vessel may be surrounded by microglia clusters, inflammatory infiltrates, small infarcts or necrosis [26, 27]. MRI studies have shown a high prevalence of hyperintense lesions in T 2 -weighted and FLAIR sequences related to small infarcts in pathological studies [28], findings which are thought to result from this cerebral vasculopathy.…”

Section: Discussionmentioning

confidence: 99%

Acute Neurolupus Manifested by Seizures Is Associated with High Frequency of Abnormal Cerebral Blood Flow Velocities

Baizabal‐Carvallo

Cantú-Brito²,

Garcı́a-Ramos³

2008

Cerebrovasc Dis

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Background: Systemic lupus erythematosus may present with a wide variety of neurological manifestations, which could be related to the presence of vasculopathy and microembolic signals (MES). Objectives: We aimed to determine the prevalence of MES and altered blood flow velocities (BFVs) by transcranial Doppler (TCD) in patients with acute neuropsychiatric lupus erythematosus (NPLE). Methods: Fifteen consecutive patients with acute NPLE (cases) and 30 patients with systemic lupus erythematosus but without acute NPLE (controls) underwent TCD testing for comparison purposes. Results: We found higher mean BFVs in cases compared with controls in the left (100 vs. 73.5 cm/s, p = 0.018) and in the right (96 vs. 70 cm/s, p = 0.013) middle cerebral arteries. The proportion of MES in both groups was the same (13%). Abnormal TCDs were more frequent in patients with acute NPLE, 67 versus 17% (p = 0.001), and occurred more often in patients who presented seizures. Conclusions: The frequency of MES was the same in both groups; however, patients with seizures due to acute NPLE usually present with higher BFVs than controls. This could be a marker of diffuse acute cerebral vasculopathy.

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“…Несомнено, моделот на клинички манифестации се рефлектира во можностите на МР: локализирани невролошки знаци и напади се поврзани со фокални абнормалности на МР почесто од колку дифузни промени. Сепак, не постои стандардизиран МР модел, кој е дијагностички специфичнен за невролупус [36,37]. Сепак, некои карактеристични промени се земаат во разгледување како: кај акутните лезии немање на дискретни граници, има среден интензитет на Т2 снимки, имаат елипсоидна форма и се наоѓаат на границата меѓу кортексот и белата маса, или во белата маса.…”

Section: снимања на мозочниот паренхимunclassified

Невролупус

Bundovska

2015

Maced Med Electron J

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Системски лупус еритематозус (СЛЕ) не е невообичаена состојба. Повеќето невролози се свесни дека тaa може да предизвика широк спектар на невролошки компликации, и СЛЕ речиси секогаш се појавува на листа на "диференцијална дијагноза“ во случаи на клиничка несигурност. Сепак, точната природа на манифестациите на СЛЕ во централниот и периферниот нервен систем е можеби помалку разбрана, и заблудите за феноменот и третманот се чести. Ќе бидат разгледани некои од главните примарни невролошки компликации на СЛЕ - 'невролупус' - земјќи во обзир дека второстепените проблеми во врска со други последици од СЛЕ (на пример, хипертензивна болест на ЦНС појава како резултат на бубрежен лупус) не се ниту помалку сериозни ниту пак може полесно да се лекуваат.

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MRI and the brain in systemic lupus erythematosus

Cited by 50 publications

References 5 publications

Sporadic Creutzfeldt-Jakob disease: a rare cause of rapid cognitive decline in a patient with systemic lupus erythematosus

Sporadic Creutzfeldt-Jakob disease: a rare cause of rapid cognitive decline in a patient with systemic lupus erythematosus

Acute Neurolupus Manifested by Seizures Is Associated with High Frequency of Abnormal Cerebral Blood Flow Velocities

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