MRI, Antibody-Guided Scintigraphy, and Glucose Metabolism in Uveal Melanoma

Lucignani, Giovanni; Paganelli, Giovanni; Modorati, Giulio; Pieralli, S.; Rizzo, Giovanna; Magnani, Patrizia; Colombo, F.; Zito, Felicia; Landoni, Claudio; Scotti, Giuseppe; Brancato, Rosario; Fazio, Ferruccio

doi:10.1097/00004728-199201000-00014

Cited by 27 publications

(7 citation statements)

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“…Parallel to recent advances in imaging techniques, tumourseeking radionuclides and monoclonal antibodies, there has been a growing interest in scintigraphic evaluation of uveal melanomas, Several immunoscintigraphic studies have found detection rates ranging from 43 to 93% by using [99mTc]labelled monoclonal antibody 225.28s, which is directed 'against high molecular weight melanoma-associated antigens.6-9 These studies have shown that size is a significant factor in detecting the tumour and that lesions having a height of less than 2.7 mm could not be imaged, even with SPECT.7-10 Magnetic resonance imaging was found to be more sensitive for hypomelanotic and small size lesions. 10 Schaling et al9 demonstrated that planar immunoscintigraphy had a correct positive diagnosis of choroidal melanoma in 49% of cases, which did not increase with SPECT, whereas ultrasonography and fluorescein angiography had sensitivity levels of 88 and 30%, respectively. Modorati etal.1l were able to increase the detection rate of immunoscintigraphy from 71.4 to 100% by using a three-step technique incorporating avidin-biotin complex into the system.…”

Section: Discussionmentioning

confidence: 99%

Technetium‐99m (V) dimercaptosuccinic acid uptake by choroidal melanoma before and after iodine‐ 125 brachytherapy

Kıratlı

Ercan

et al. 1998

Australian and New Zealand Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Technetium‐99m (V) dimercaptosuccinic acid uptake by choroidal melanoma before and after iodine‐ 125 brachytherapy

Kıratlı

Ercan

et al. 1998

Australian and New Zealand Journal of Ophthalmology

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“…Some technical improvements such as respiratory gating and the late acquisition phase after FDG injection could improve results [58]. Some studies suggest that glucidic metabolism of uveal melanoma is variable [59]. In a recent study by Strobel et al [60] comparing metastases of cutaneous and uveal melanoma, 59% of uveal melanoma lesions did not have a significant FDG uptake.…”

Section: The Staging Of the Intrahepatic Disease Is The Real Challengementioning

confidence: 99%

Therapeutic Options in Metastatic Uveal Melanoma

Mariani¹,

Servois²,

Piperno‐Neumann³

2011

Current Concepts in Uveal Melanoma

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Systemic treatments for metastatic uveal melanoma patients give poor results. R0 resection of liver metastases showed a real benefit in survival in a very highly selected population. Based on our multivariate analysis, we propose surgical treatment to metastatic patients with time from diagnosis of uveal melanoma to liver metastases > 24 months, number of liver metastases ≤4 lesions, and absence of detectable miliary disease. Liver MRI is currently the best imaging method in this context even if miliary disease is still difficult to diagnose. Molecular and chromosomal classification strongly predicting metastatic death has to be used to identify genetic profiles and pathways involved in the pathogenesis of uveal melanoma leading to new targeted therapeutic strategies.

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“…[1][2][3][4][5][6][7][8] The patient received an IV injection of 9.6 mCi F-18 FDG. After an initial uptake phase of approximately 60 minutes, a CT scan without IV contrast was acquired for attenuation correction and localizing purposes only.…”

Section: Figurementioning

confidence: 99%

Choroidal Melanoma With Hematogenous Spread to the Liver: F-18 FDG PET/CT Findings

Bawa

Sidhu²,

Galt³

et al. 2006

Clinical Nuclear Medicine

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Melanomas usually metastasize through the lymphatic route. However, choroidal melanoma invariably disseminates hematogenously to the liver. Liver metastasis develops in approximately two thirds of patients with recurrent uveal melanoma. The PET scan is a sensitive tool for the detection and localization of hepatic and extrahepatic metastatic choroidal melanoma. We report a patient with a history of choroidal melanoma in the left eye. The patient had undergone a scleral plaque placement followed by an enucleation and an implant. He was referred to us for a PET scan for restaging. No prior PET scan was available for comparison. An implant in the eye with intense FDG-avid liver metastasis should raise suspicion of choroidal melanoma. REFERENCES 1. Kurli M, Reddy S, Tena LB, et al. Whole body positron emission tomography/computed tomography staging of metastatic choroidal melanoma. Am J Ophthalmol. 2005;140:193-199. 2. Kumar R, Alavi A. Clinical applications of fluorodeoxyglucose-positron emission tomography in the management of malignant melanoma. Curr Opin Oncol. 2005;17:154 -159. 3. Kumar R, Mavi A, Bural G, et al. Fluorodeoxyglucose-PET in the management of malignant melanoma. Radiol Clin North Am. 2005;43:23-33. 4. Lucignani G, Paganelli G, Modorati G, et al. MRI, antibody-guided scintigraphy, and glucose metabolism in uveal melanoma. J Comput Assist Tomogr. 1992;16:77-83. 5. Toivonen P, Makitie T, Kujala E, et al. Microcirculation and tumorinfiltrating macrophages in choroidal and ciliary body melanoma and corresponding metastases. Invest Ophthalmol Vis Sci. 2004;45:1-6. 6. Gulec SA, Faries MB, Lee CC, et al. The role of fluorine-18 deoxyglucose positron emission tomography in the management of patients with metastatic melanoma: impact on surgical decision making. Clin Nucl Med. 2003;28:961-965. 7. Hunyadi J, Szakall S Jr, Gilde K, et al. The role of PET scan in the diagnosis of malignant melanoma. Orv Hetil. 2002;143(suppl 3):1272-1275. 8. Stas M, Stroobants S, Dupont P, et al. 18-FDG PET scan in the staging of recurrent melanoma: additional value and therapeutic impact. Melanoma Res. 2002;12:479 -490.

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MRI, Antibody-Guided Scintigraphy, and Glucose Metabolism in Uveal Melanoma

Cited by 27 publications

References 0 publications

Technetium‐99m (V) dimercaptosuccinic acid uptake by choroidal melanoma before and after iodine‐ 125 brachytherapy

Technetium‐99m (V) dimercaptosuccinic acid uptake by choroidal melanoma before and after iodine‐ 125 brachytherapy

Therapeutic Options in Metastatic Uveal Melanoma

Choroidal Melanoma With Hematogenous Spread to the Liver: F-18 FDG PET/CT Findings

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