2011
DOI: 10.1093/neuonc/nor122
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MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas

Abstract: The apparent diffusion coefficient (ADC) determined from MR diffusion tensor imaging (DTI) has shown promise for distinguishing World Health Organization grade II astrocytoma (AS) from the more prognostically favorable grade II oligodendroglioma (OD). Since mixed oligoastrocytomas (OAs) with codeletions in chromosomes 1p and 19q confer prognoses similar to those of OD, we questioned whether a previously determined ADC-based criterion for distinguishing OD and AS would hold on an independent set of gliomas that… Show more

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Cited by 33 publications
(33 citation statements)
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“…18,[26][27][28][29] Our finding of an association between lower ADC values with 1p/19q codeletion has previously been described in small studies. 16,30 Further investigation will be necessary to define the optimal way of measuring ADC and to determine the physiologic correlate of ADC values in genetically defined oligodendroglioma. 30 While a strength of this current study is its large number of subjects relative to previous publications, it has limitations that should be understood when applying the findings.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…18,[26][27][28][29] Our finding of an association between lower ADC values with 1p/19q codeletion has previously been described in small studies. 16,30 Further investigation will be necessary to define the optimal way of measuring ADC and to determine the physiologic correlate of ADC values in genetically defined oligodendroglioma. 30 While a strength of this current study is its large number of subjects relative to previous publications, it has limitations that should be understood when applying the findings.…”
Section: Discussionmentioning
confidence: 99%
“…16,30 Further investigation will be necessary to define the optimal way of measuring ADC and to determine the physiologic correlate of ADC values in genetically defined oligodendroglioma. 30 While a strength of this current study is its large number of subjects relative to previous publications, it has limitations that should be understood when applying the findings. First, the analysis cohort comprised solely infiltrating gliomas with oligodendroglial features by microscopy.…”
Section: Discussionmentioning
confidence: 99%
“…Jenkinson et al 22 reported that tumors with intact 1p/19q had higher maximum ADC value on DWI. Khayal et al 15 reported that ADC determined from DTI showed promising value for distinguishing oligoastrocytomas with codeletions in chromosomes 1p and 19q from those with intact 1p/19q chromosomes.…”
Section: Discussionmentioning
confidence: 99%
“…DTI has been used to detect the genetic characteristics of gliomas. 15 In the current study, we explore whether the metrics determined from DTI can help to detect IDH1 gene status of astrogliomas noninvasively.…”
mentioning
confidence: 99%
“…The Apparent Diffusion Coefficient (ADC) is used as a measure of cellularity [811], and low ADC is associated with shorter progression free and overall survival in LGGs [1113]. ADC may distinguish between different histological sub-types of LGG [14], and lesions that have transformed to a higher grade and are likely to fail treatment early [15–16]. Fractional Anisotropy (FA) is a measure of the degree of directionality in diffusion [7].…”
Section: Introductionmentioning
confidence: 99%