MRI assessment of basal ganglia iron deposition in Parkinson's disease

Wallis, L. I.; Paley, Martyn N.J.; Graham, Jacqueline; Grünewald, Richard A.; Wignall, Emma; Joy, Harriet; Griffiths, Paul D.

doi:10.1002/jmri.21563

Cited by 150 publications

(134 citation statements)

References 30 publications

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“…Neuromelanin-sensitive MRI may underestimate SNc volume because of ferrous accumulation in the SNc of PD patients [17]. Correction of ferrous accumulation might In the current study, semi-automated measurement of SNc volume was feasible, with only several clicks on the SNc (for seeding points) and decussation of the superior cerebellar peduncle (for signal normalization) required.…”

Section: Discussionmentioning

confidence: 86%

3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson’s disease

et al. 2013

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Purpose: Neuromelanin-sensitive MRI has been reported to be used in the diagnosis of Parkinson's disease (PD), which results from loss of dopamine-producing cells in the substantia nigra pars compacta (SNc). In this study, we aimed to apply a 3D turbo field echo (TFE) sequence for neuromelanin-sensitive MRI and to evaluate the diagnostic performance of semi-automated method for measurement of SNc volume in patients with PD.Methods: We examined 18 PD patients and 27 healthy volunteers (control subjects). A 3D TFE technique with off-resonance magnetization transfer pulse was used for neuromelanin-sensitive MRI on a 3T scanner. The SNc volume was semi-automatically measured using a region-growing technique at various thresholds (ranging from 1.66 to 2.48), with the signals measured relative to that for the superior cerebellar peduncle.Receiver operating characteristic (ROC) analysis was performed at all thresholds. Intra-rater reproducibility was evaluated by intraclass correlation coefficient (ICC).Results: The average SNc volume in the PD group was significantly smaller than that in the control group at all the thresholds (P < 0.01, student t test). At higher thresholds (>2.0), the area under the curve of ROC (Az) increased (0.88). In addition, we observed balanced sensitivity and specificity (0.83 and 0.85, respectively). At lower thresholds, sensitivity tended to increase but specificity reduced in comparison with that at higher thresholds. ICC was larger than 0.9 when the threshold was over 1.86.Conclusions: Our method can distinguish the PD group from the control group with high sensitivity and specificity, especially for early stage of PD.

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Section: Discussionmentioning

confidence: 86%

3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson’s disease

et al. 2013

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“…It should be noticed that the tissue used in that study came from unselected parts of PUT, that is, there was no control for a potential rostral/caudal gradient. The findings suggest that iron levels will vary according to the selected regions of PUT, and this may help explain some of the inconsistency in comparison between PD and control subjects [27] .…”

Section: Phase Distribution In Selected Roismentioning

confidence: 91%

Determination of brain iron content in patients with Parkinson’s disease using magnetic susceptibility imaging

et al. 2009

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Objective To compare the phase radians in several cerebral regions between patients with Parkinson's disease (PD) and control subjects, and to evaluate whether iron deposition quantified by susceptibility-weighted imaging (SWI) is related to the severity of motor symptoms of PD. Methods SWI consisted of both magnitude and phase images from a fully flow-compensated, 3-dimensional and gradient-echo (GRE) sequence. Magnitude and phase data were collected at GE HD 1.5T.The regions evaluated included frontal white matter, grey matter, cerebrospinal fluid, putamen, caudate nucleus (CN), substantia nigra pars compacta (SNc), substantia nigra pars reticulata (SNr), and red nucleus (RN). A total number of 42 patients (12 patients without cognitive dysfunction, and 30 with cognitive dysfunction from mild to moderate degrees) and 30 control subjects were employed in the present study. Results The phase radians of SNc, CN and RN in PD patients were lower than those in control subjects (P<0.05). Conclusion The phase radians can be used to estimate the brain iron deposition in PD patients, which may be helpful in the diagnosis and longitudinal monitoring of PD.

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“…Abnormally high levels of iron have been reported in the brain regions of patients with various neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) (1,2). In these diseases, progressive iron accumulation has also been observed in activated microglia, as the brain resident immune cells (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Valproic acid attenuates nitric oxide and interleukin‑1β production in lipopolysaccharide‑stimulated iron‑rich microglia

Mairuae

Cheepsunthorn

2018

biom rep

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Abstract. Iron accumulation in activated microglia has been consistently reported in neurodegenerative diseases. Previous results suggest that these cells facilitate neuroinflammation leading to neuronal cell death. Therefore, chemical compounds that alleviate the activation of iron-rich microglia may result in neuroprotection. In the present study, the effect of valproic acid (VPA) on microglial activation under iron-rich conditions was investigated. BV-2 microglial cells were exposed to lipopolysaccharide (LPS; 1 µg/ml) and iron (300 µg/ml) with or without VPA (1.6 mM). The results demonstrated that VPA attenuated the activation of iron-rich BV2 cells induced by LPS by down-regulating the mRNA expression of inducible nitric oxide (NO) synthase and interleukin 1β (IL-1β; P<0.01), to ultimately reduce the production of NO and IL-1β (P<0.01). These events were accompanied by an attenuation in the nuclear translocation of nuclear factor-κB p65 subunit (P<0.01). These findings suggest that VPA may be therapeutically useful for attenuating the activation of iron-rich microglia.

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MRI assessment of basal ganglia iron deposition in Parkinson's disease

Cited by 150 publications

References 30 publications

3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson’s disease

3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson’s disease

Determination of brain iron content in patients with Parkinson’s disease using magnetic susceptibility imaging

Valproic acid attenuates nitric oxide and interleukin‑1β production in lipopolysaccharide‑stimulated iron‑rich microglia

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