MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe

Jiang, Dengrong; Liu, Peiying; Lin, Zixuan; Hazel, Kaisha; Pottanat, George; Lucke, Emma; Moghekar, Abhay; Pillai, Jay J.; Lu, Hanzhang

doi:10.1016/j.neuroimage.2022.119829

Cited by 7 publications

(7 citation statements)

References 53 publications

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“…The observed mean baseline OEF across selected brain regions of 35.1% is consistent with the physiological range of previous PET and MRI studies (Yamaguchi et al, 1986;Leenders et al, 1990;Cho et al, 2021;Jiang et al, 2023). We observed an OEF reduction of 6.2%-8.7% (absolute oxygenation) in significant DMN regions, which was smaller in magnitude than the 15.6% absolute OEF decrease in the sagittal sinus from past ACZ studies on healthy controls (Václavů et al, 2020).…”

Section: Baseline Oef and Change With Acetazolamide In Healthy Partic...supporting

confidence: 89%

“…OEF can serve as a functional biomarker due to its sensitivity in the early stages of brain diseases and aging, as neural activity is tightly linked to the brain's oxygen consumption (Watts et al, 2018). At baseline, average OEF values in the medial temporal lobe were measured to be 25.9% ± 3.0% (Table 1), consistent with prior MRI studies' measurement of OEF in vessels supplying the MTL of 23.9% using T 2 -relaxation-under-phase-contrast approach (Jiang et al, 2023). Even though there was a decreasing trend, we observed no significant change in MTL OEF during vasodilation (P 0.609).…”

Section: Effects Of Vasodilation In Cerebral Regionssupporting

confidence: 79%

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Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation

Le,

Wheeler,

Holy

et al. 2023

Front. Physiol.

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Introduction: We aimed to demonstrate non-invasive measurements of regional oxygen extraction fraction (OEF) from quantitative BOLD MRI modeling at baseline and after pharmacological vasodilation. We hypothesized that OEF decreases in response to vasodilation with acetazolamide (ACZ) in healthy conditions, reflecting compensation in regions with increased cerebral blood flow (CBF), while cerebral metabolic rate of oxygen (CMRO2) remained unchanged. We also aimed to assess the relationship between OEF and perfusion in the default mode network (DMN) regions that have shown associations with vascular risk factors and cerebrovascular reactivity in different neurological conditions.Material and methods: Eight healthy subjects (47 ± 13 years, 6 female) were scanned on a 3 T scanner with a 32-channel head coil before and after administration of 15 mg/kg ACZ as a pharmacological vasodilator. The MR imaging acquisition protocols included: 1) A Gradient Echo Slice Excitation Profile Imaging Asymmetric Spin Echo scan to quantify OEF, deoxygenated blood volume, and reversible transverse relaxation rate (R2’) and 2) a multi-post labeling delay arterial spin labeling scan to measure CBF. To assess changes in each parameter due to vasodilation, two-way t-tests were performed for all pairs (baseline versus vasodilation) in the DMN brain regions with Bonferroni correction for multiple comparisons. The relationships between CBF versus OEF and CBF versus R2’ were analyzed and compared across DMN regions using linear, mixed-effect models.Results: During vasodilation, CBF significantly increased in the medial frontal cortex (P=0.004), posterior cingulate gyrus (pCG) (P=0.004), precuneus cortex (PCun) (P=0.004), and occipital pole (P=0.001). Concurrently, a significant decrease in OEF was observed only in the pCG (8.8%, P=0.003) and PCun (8.7%,P=0.001). CMRO2 showed a trend of increased values after vasodilation, but these differences were not significant after correction for multiple comparisons. Although R2’ showed a slightly decreasing trend, no statistically significant changes were found in any regions in response to ACZ. The CBF response to ACZ exhibited a stronger negative correlation with OEF (β=−0.104±0.027; t=−3.852,P<0.001), than with R2’ (β=−0.016±0.006; t=−2.692,P=0.008).Conclusion: Quantitative BOLD modeling can reliably measure OEF across multiple physiological conditions and captures vascular changes with higher sensitivity than R2’ values. The inverse correlation between OEF and CBF across regions in DMN, suggests that these two measurements, in response to ACZ vasodilation, are reliable indicators of tissue health in this healthy cohort.

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Section: Baseline Oef and Change With Acetazolamide In Healthy Partic...supporting

confidence: 89%

Section: Effects Of Vasodilation In Cerebral Regionssupporting

confidence: 79%

Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation

Le,

Wheeler,

Holy

et al. 2023

Front. Physiol.

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“…Prior studies have reported the increasing oxygen extraction fraction in normal aging, which is consistent with our observations of age-related Δ χ vein changes in IVV. This increased oxygen utilization with age can be explained by the two important physiological factors ( Peng et al, 2014 ; Jiang et al, 2023 ). As mentioned before, the CBF tends to decrease with age.…”

Section: Discussionmentioning

confidence: 99%

In vivo mapping of hippocampal venous vasculature and oxygenation using susceptibility imaging at 7T

Li,

Buch,

Sun

et al. 2024

NeuroImage

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“…Steering deviation was predicted using a LMEs model. Mixed effects modeling is commonly adopted in neuroscience studies [85,86] and was chosen since it holds several advantages over traditional F-tests in assessing predictive actions. These include the ability to account for individual differences in participant characteristics, which was achieved in the present study by modeling each participant's intercept as a random effect.…”

Section: Statistical and Connectivity Approachmentioning

confidence: 99%

Pupil-linked arousal correlates with neural activity prior to sensorimotor decisions

Koorathota,

Ma,

Faller

et al. 2023

J. Neural Eng.

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Objective. Sensorimotor decisions require the brain to process external information and combine it with relevant knowledge prior to actions. In this study, we explore the neural predictors of motor actions in a novel, realistic driving task designed to study decisions while driving. Approach. Through a spatiospectral assessment of functional connectivity during the premotor period, we identified the organization of visual cortex regions of interest into a distinct scene processing network. Additionally, we identified a motor action selection network characterized by coherence between the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC). Main results. We show that steering behavior can be predicted from oscillatory power in the visual cortex, DLPFC, and ACC. Power during the premotor periods (specific to the theta and beta bands) correlates with pupil-linked arousal and saccade duration. Significance. We interpret our findings in the context of network-level correlations with saccade-related behavior and show that the DLPFC is a key node in arousal circuitry and in sensorimotor decisions.

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MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe

Cited by 7 publications

References 53 publications

Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation

Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation

In vivo mapping of hippocampal venous vasculature and oxygenation using susceptibility imaging at 7T

Pupil-linked arousal correlates with neural activity prior to sensorimotor decisions

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