MRI-based nomogram for differentiation of ovarian fibrothecoma and broad ligament myoma

Abstract

Currently, there are no effective approaches for differentiating ovarian fibrothecoma (OF) from broad ligament myoma (BLM). This retrospective study aimed to construct a nomogram prediction model based on MRI to differentiate OF from BLM. The quantitative and qualitative MRI features of 41 OFs and 51 BLMs were compared. Three models were established based on the combination of these features. The ability of the models to differentiate between the two cancers was assessed by ROC analysis. A nomogram based on the best model was constructed for clinical application. The three models showed good performance in differentiating between OF and BLM. The areas under the curve (AUC) of the models based on quantitative and qualitative variables were 0.88 (95% CI: 0.79–0.96) and 0.85 (95% CI: 0.76–0.93), respectively. The combined model designed from the significant variables exhibited the best diagnostic performance with the highest AUC of 0.92 (95% CI: 0.86–0.98). Calibration of the nomogram showed that the predicted probability matched the actual probability well. Analysis of the decision curve demonstrated that the nomogram was clinically useful. Relative T1 value, stone paving sign, enhancement patterns, and ascites were identified as valuable predictors for identifying OF or BLM. The MRI-based nomogram can serve as a preoperative tool to differentiate OF from BLM.

A Case Report of Meigs’ Syndrome Caused by Ovarian Fibrothecoma with High Levels of CA125

“…Fibrothecomas are rare ovarian tumors that originate from sex-cord stromal cells. 3 They are usually benign, and their incidence among all ovarian tumors is estimated to be 1–4%. 4 Fibrothecomas are more common in perimenopausal and postmenopausal women.…”

Hypermetabolic Broad Ligament Leiomyoma in Postmenopausal Women Mimicking Ovarian Tumors on 18F-FDG PET/CT

“…Uterine leiomyomas are the most common benign gynecologic tumor, whereas extrauterine leiomyomas are less frequent 1 . Extrauterine leiomyomas often originate from the broad ligament or fallopian tube 2,3 . Most leiomyomas exhibit mild to moderate FDG uptake 4–6 .…”

“…1 Extrauterine leiomyomas often originate from the broad ligament or fallopian tube. 2,3 Most leiomyomas exhibit mild to moderate FDG uptake. [4][5][6] The FDG uptake of leiomyomas declines with age and tends to disappear after menopause.…”